Angela Panoskaltsis-Mortari

Vice Chair for Research, Professor, Division of Pediatric Blood and Marrow Transplantation & Cellular Therapy
Faculty, Department of Pediatrics
Professor, Department of Medicine
Director, University of Minnesota 3D Bioprinting Facility
Director, Cytokine Reference Laboratory
Associate Director, TL1 Program (CTSI)


Angela Panoskaltsis-Mortari, PhD is a Professor of Pediatrics in the Division of Blood and Marrow Transplant & Cellular Therapy. She is also a Professor of Medicine in the Division of Pulmonary, Allergy, Critical Care and Sleep. Dr. Panoskaltsis-Mortari is the Director of the Cytokine Reference Laboratory, the Director of the 3D Bioprinting Facility at the University of Minnesota and Vice Chair for Research for the Department of Pediatrics.
Dr. Panoskaltsis-Mortari received her PhD from the University of Western Ontario. She was a post-doctoral fellow in the Department of Pathology at the University of Alabama and a post-doctoral research associate in the Department of Pediatrics at the University of Minnesota. She joined the University of Minnesota faculty in 1995.
Dr. Panoskaltsis-Mortari has board certification from the American Board of Medical Laboratory Immunology. She is a member of numerous immunology, pulmonary, and hematology professional societies, and the author of over 275 articles which have appeared in such publications as Advanced Materials, Journal of Clinical Investigation, Blood, Biology of Blood and Marrow Transplantation, and American Journal of Physiology (Lung, Cell. & Mol. Physiol.).

Research Summary

With 25 years of experience in animal models of stem cell transplant, lung injury, mesenchymal stem/stromal cell therapy and the biology of graft-vs-host disease (GVHD) after bone marrow transplant, Dr. Angela Panoskaltsis-Mortari's work has evolved into the bioengineering field, and she is recognized as one of the thought leaders in lung bioengineering. Dr. Panoskaltsis-Mortari's laboratory research currently focuses upon 2 major themes: 1) bioengineering autologous tissues such as trachea and esophagus using 3D bioprinting and customized hydrogels including decellularized extracellular matrix; and 2) 3D bioprinting of cancer models.
Dr. Panoskaltsis-Mortari established and directs the 3D Bioprinting Facility at the University of Minnesota. She also directs the UMN Cytokine Reference Laboratory (a CLIA-licensed facility). She is a member of the Stem Cell Institute, the Institute for Engineering in Medicine, the Lillehei Heart Institute, the Masonic Cancer Center, the Center for Immunology, and the Robotics Institute. She is funded by the NIH, has mentored many post-docs, MD trainees, graduate students and undergrads in various training programs. Her goal is to realize the potential of regenerative medicine by converging the fields of stem cell biology, mechanical & biomedical engineering, biomaterials, physiology, robotics, and surgery to bioengineer autologous tissues/organs for transplant using a patient's own cells that would not be rejected by their immune system.


PhD in Microbiology & Immunology, University of Western Ontario, London, ON, Canada
MSc in Microbiology & Immunology, The University of Western Ontario, London, ON, Canada

Fellowships, Residencies, and Visiting Engagements

Post-Doctoral Fellowship in Pediatric BMT,
University of Minnesota Medical School
Minneapolis, Minnesota, United States
Post-Doctoral Fellowship in Pathology,
University of Alabama
Birmingham, Alabama, United States

Licensures and Certifications

American Board of Medical Laboratory Immunology

Honors and Recognition

Sara Evans Faculty Woman Scholar/Leader Award, University of Minnesota Office of the Executive Vice President and Provost and the Women's Center
Innovator in Basic Science Award, Department of Pediatrics, University of Minnesota
Selected Publications

Selected Publications

Galliger Z, Vogt CD, Helms, HR, Panoskaltsis-Mortari A. Extracellular matrix microparticles improve GelMA bioink resolution for 3D bioprinting at ambient temperature. Macromol Mater Eng. 2022;Oct;307(10):2200196. doi: 10.1002/mame.202200196. Epub 2022 Jul 21. PMID: 36531127; PMCID: PMC9757590.
Akinnola I, Rossi DR, Meyer C, Lindsey A, Haase DR, Fogas S, Ehrhardt MJ, Blue RE, Price AP, Johnson M, Alvarez DF, Taylor DA, Panoskaltsis-Mortari A. Engineering functional vasculature in decellularized lungs depends on comprehensive endothelial cell tropism. Front Bioeng Biotechnol. 2021; Aug 16;9:727869. doi: 10.3389/fbioe.2021.727869. PMID: 34485262; PMCID: PMC8415401.
Vogt CD, Panoskaltsis-Mortari A. Tissue engineering of the gastroesophageal junction. J Tissue Eng Regen Med. 2020;Jun;14(6):855-868. doi: 10.1002/term.3045. Epub 2020 Apr 23. PMID: 32304170; PMCID: PMC7286780.
Galliger Z, Vogt CD, Panoskaltsis-Mortari A. 3D bioprinting for lungs and hollow organs. Transl Res. 2019;Sep;211:19-34. doi: 10.1016/j.trsl.2019.05.001. Epub 2019 May 14. PMID: 31150600; PMCID: PMC6702089.
Meng F, Meyer CM, Joung D, Vallera DA, McAlpine MC, Panoskaltsis-Mortari A. 3D bioprinted in vitro metastatic models via reconstruction of tumor microenvironments. Adv Mater. 2019;Mar;31(10):e1806899. doi: 10.1002/adma.201806899. Epub 2019 Jan 21. PMID: 30663123; PMCID: PMC6996245.
Price AP, Godin LM, Domek A, Cotter T, Taylor DA, Panoskaltsis-Mortari A. Automated decellularization of intact, human-sized lungs for tissue engineering. Tissue Eng Part C Methods. 2015;21:94-103. PMID: 24826875; PMCID: PMC4290793.



Pediatric Blood and Marrow Transplantation & Cellular Therapy
Mayo Mail Code 366
420 Delaware Street SE
Minneapolis, MN 55455

Administrative Contact

Janelle Willard
Administrative Phone: 612-626-2961
Administrative Email:
Administrative Fax Number: 612-626-4074