Paul Orchard
,
Credentials
MD
Bio
Dr. Paul Orchard is the Medical Director of the Inherited Metabolic and Storage Disease Program and a Professor in the Department of Pediatrics, Division of Blood and Marrow Transplant & Cellular Therapy. Dr. Orchard's focus is in the use of hematopoietic stem cell transplantation and other cell therapies for inherited metabolic disorders, with a special interest in the inherited leukodystrophies, the mucopolysaccharidoses and osteopetrosis. His clinical research is in evolving new and combination therapies to decrease toxicity and improve outcomes, with a particular interest in the use of gene therapy approaches.
Research Summary
Hematopoietic Cell Transplantation of Genetic Disorders Transplant related toxicity and graft failure Use of reduced intensity preparative regimens Risk factors affecting outcomes following transplantation
Osteopetrosis Biology and genetics of osteopetrosis Correlations of clinical and genetic parameters to outcome and prognosis Hematopoietic transplantation and other therapies
Gene Therapy T cell engineering with "suicide genes" for transplantation Infusions of mismatched T cells with following genetic manipulation Treatment of genetic and metabolic diseases with gene therapy
Development of Alternative Cellular Therapy Use of mesenchymal stem cells for genetic diseases Infusions of immunologically active cell populations
Clinical Summary
Bone marrow transplants to treat genetic diseases; Osteopetrosis; Inherited conditions
Education
Fellowships, Residencies, and Visiting Engagements
Licensures and Certifications
Honors and Recognition
Media Appearances
Selected Publications
Selected Presentations
Grants and Patents
Patents
Contact
Address
Pediatric Blood and Marrow Transplantation & Cellular TherapyMayo Mail Code 366
420 Delaware Street SE
Minneapolis, MN 55455