Eric Feczko, PhD, MBI

Assistant Professor, Department of Pediatrics

National Library of Medicine Postdoctoral Fellowship, Department of Medical Informatics and Clinical Epidemiology, Oregon Health and Sciences University, Portland, OR

PhD, Neuroscience, Washington University School of Medicine, St. Louis, MO

MBI, Oregon Health and Sciences University, Portland, OR

Summary

Research

Research Summary/Interests

To understand how different mechanisms contribute to heterogeneity of child mental development; To develop better tools for assisting diagnosis, accommodation, and improvement of children with developmental conditions like autism and ADHD

Publications

Dr. Feczko is the contributor of many manuscripts, which have appeared in premier peer-reviewed publications. Following are selected peer-reviewed papers, 2017 - present:

Feczko E, Fair DA (2020): Methods and Challenges for Assessing Heterogeneity. Biol Psychiatry. doi: 10.1016/j.biopsych.2020.02.015.

Godfrey JR, Pincus M, Kovacs-Balint Z, Feczko E, Earl E, Miranda-Dominguez O, Fair DA, Jones SR, Locke J, Sanchez MM, Wilson ME, Michopoulos V. Obesogenic Diet-Associated C-Reactive Protein Predicts Reduced Central Dopamine and Corticostriatal Functional Connectivity in Female Rhesus Monkeys. Brain Behav Immun. 2020 Mar 30. pii: S0889-1591(19)31625-3. doi: 10.1016/j.bbi.2020.03.030. [Epub ahead of print] PubMed PMID: 32240763.

Cordova M, Shada K, Demeter DV, Doyle O, Miranda-Dominguez O, Perrone A, Schifsky E, Graham A, Fombonne E, Langhorst B, Nigg J, Fair DA, Feczko E. Heterogeneity of executive function revealed by a functional random forest approach across ADHD and ASD. Neuroimage Clin. 2020 Mar 16;26:102245. doi: 10.1016/j.nicl.2020.102245. [Epub ahead of print] PubMed PMID: 32217469; PubMed Central PMCID: PMC7109457.

Fair DA, Miranda-Dominguez O, Snyder AZ, Perrone A, Earl EA, Van AN, Koller JM, Feczko E, Tisdall MD, van der Kouwe A, Klein RL, Mirro AE, Hampton JM, Adeyemo B, Laumann TO, Gratton C, Greene DJ, Schlaggar BL, Hagler DJ Jr, Watts R, Garavan H, Barch DM, Nigg JT, Petersen SE, Dale AM, Feldstein-Ewing SW, Nagel BJ, Dosenbach NUF. Correction of respiratory artifacts in MRI head motion estimates. Neuroimage. 2020 Mar;208:116400. doi: 10.1016/j.neuroimage.2019.116400. Epub 2019 Nov 25. PubMed PMID: 31778819.

Ramirez JSB, Graham AM, Thompson JR, Zhu JY, Sturgeon D, Bagley JL, Thomas E, Papadakis S, Bah M, Perrone A, Earl E, Miranda-Dominguez O, Feczko E, Fombonne EJ, Amaral DG, Nigg JT, Sullivan EL, Fair DA. Maternal Interleukin-6 Is Associated With Macaque Offspring Amygdala Development and Behavior. Cereb Cortex. 2019 Oct 26. pii: bhz188. doi: 10.1093/cercor/bhz188. [Epub ahead of print] PubMed PMID: 31665252.

Marek S, Tervo-Clemmens B, Nielsen AN, Wheelock MD, Miller RL, Laumann TO, Earl E, Foran WW, Cordova M, Doyle O, Perrone A, Miranda-Dominguez O, Feczko E, Sturgeon D, Graham A, Hermosillo R, Snider K, Galassi A, Nagel BJ, Ewing SWF, Eggebrecht AT, Garavan H, Dale AM, Greene DJ, Barch DM, Fair DA, Luna B, Dosenbach NUF. Identifying reproducible individual differences in childhood functional brain networks: An ABCD study. Dev Cogn Neurosci. 2019 Dec;40:100706. doi: 10.1016/j.dcn.2019.100706. Epub 2019 Sep 19. PubMed PMID: 31614255; PubMed Central PMCID: PMC6927479.

Feczko E, Miranda-Dominguez O, Marr M, Graham AM, Nigg JT, Fair DA. The Heterogeneity Problem: Approaches to Identify Psychiatric Subtypes. Trends in Cognitive Sciences. 2019; 23(7):584-601. doi: 10.1016/j.tics.2019.03.009. PMID: 31153774

Henry TR, Feczko E, Cordova M, Earl E, Williams S, Nigg JT, Fair DA, Gates KM. Comparing directed functional connectivity between groups with confirmatory subgrouping GIMME. Neuroimage 2018 Dec 21; 188:642-653. doi: 10.1016/j.neuroimage.2018.12.040. [Epub ahead of print]. PubMed PMID: 30583065.

Kovacs-Balint Z, Feczko E, Pincus M, Earl E, Miranda-Dominguez O, Howell B, Morin E, Maltbie E, Li L, Steele J, Styner M, Bachevalier J, Fair D, Sanchez M. Early Developmental Trajectories of Functional Connectivity Along the Visual Pathway in Rhesus Monkeys. Cereb. Cortex, 2018, Oct 1. Doi: 10.1093/cercor/bhy222. [Epub ahead of print]. PubMed PMID: 30272135.

Mills BD, Grayson DS, Shunmugavel A, Miranda-Dominguez O, Feczko E, Earl E, Neve K, Fair DA. Correlated gene expression and anatomical communication support synchronized brain activity in the mouse functional connectome. J Neurosci. 2018 May 22. pii: 2910-17. doi: 10.1523/JNEUROSCI.2910-17.2018. [Epub ahead of print] PubMed PMID: 29789379.

Xu T, Falchier A, Sullivan EL, Linn G, Ramirez JSB, Ross D, Feczko E, Opitz A, Bagley J, Sturgeon D, Earl E, Miranda-Domínguez O, Perrone A, Craddock RC, Schroeder CE, Colcombe S, Fair DA, Milham MP. Delineating the Macroscale Areal Organization of the Macaque Cortex In Vivo. Cell Rep. 2018 Apr 10;23(2):429-441. doi: 10.1016/j.celrep.2018.03.049. PubMed PMID: 29642002.

Rudolph MD, Graham AM, Feczko E, Miranda-Dominguez O, Rasmussen JM, Nardos R, Entringer S, Wadhwa PD, Buss C, Fair DA. Maternal IL-6 during pregnancy can be estimated from newborn brain connectivity and predicts future working memory in offspring. Nat Neurosci. 2018 May;21(5):765-772. doi: 10.1038/s41593-018-0128-y. Epub 2018 Apr 9. PubMed PMID: 29632361; PubMed Central PMCID: PMC5920734.

Mavigner M, Raper J, Kovacs-Balint Z, Gumber S, O'Neal JT, Bhaumik SK, Zhang X, Habib J, Mattingly C, McDonald CE, Avanzato V, Burke MW, Magnani DM, Bailey VK, Watkins DI, Vanderford TH, Fair D, Earl E, Feczko E, Styner M, Jean SM, Cohen JK, Silvestri G, Johnson RP, O'Connor DH, Wrammert J, Suthar MS, Sanchez MM, Alvarado MC, Chahroudi A. Postnatal Zika virus infection is associated with persistent abnormalities in brain structure, function, and behavior in infant macaques. Sci Transl Med. 2018 Apr 4;10(435). pii: eaao6975. doi: 10.1126/scitranslmed.aao6975. PubMed PMID: 29618564.

Godfrey JR, Diaz MP, Pincus M, Kovacs-Balint Z, Feczko E, Earl E, Miranda-Dominguez O, Fair D, Sanchez MM, Wilson ME, Michopoulos V. Diet matters: Glucocorticoid-related neuroadaptations associated with calorie intake in female rhesus monkeys. Psychoneuroendocrinology. 2018 May;91:169-178. doi: 10.1016/j.psyneuen.2018.03.008. Epub 2018 Mar 14. PubMed PMID: 29567621; PubMed Central PMCID: PMC5899678.

Feczko E, Balba N, Miranda-Dominguez O, Cordova M, Karalunas SL, Irwin L, Demeter DV, Hill AP, Langhorst BH, Grieser Painter J, Van Santen J, Fombonne EJ, Nigg JL, Fair DA. Subtyping cognitive profiles in Autism Spectrum Disorder using a random forest algorithm. Neuroimage. 2017 Dec 20. pii: S1053-8119(17)31068-6.doi: 10.1016/j.neuroimage.2017.12.044. [Epub ahead of print] PubMed PMID:29274502.

Miranda-Dominguez O, Feczko E, Grayson D, Walum H, Nigg JT, Fair DA. Heritability of the human connectome: a connectotyping study. Network Neuroscience. 2017 Nov 2. doi: 10.1162/NETN_a_00029. [Epub ahead of print].

Eggebrecht AT, Elison JT, Feczko E, Todorov A, Wolff JJ, Kandala S, Adams CM, Snyder AZ, Lewis JD, Estes AM, Zwaigenbaum L, Botteron KN, McKinstry RC, Constantino JN, Evans A, Hazlett HC, Dager S, Paterson SJ, Schultz RT, Styner MA, Gerig G, Das S, Kostopoulos P, Schlaggar BL, Petersen SE, Piven J, Pruett JR Jr; IBIS Network .. Joint Attention and Brain Functional Connectivity in Infants and Toddlers. Cereb Cortex. 2017 Jan 6. doi: 10.1093/cercor/bhw403. [Epub ahead of print] PubMed PMID: 28062515.

Savalia NK, Agres PF, Chan MY, Feczko EJ, Kennedy KM, Wig GS. Motion-related artifacts in structural brain images revealed with independent estimates of in-scanner head motion. Hum Brain Mapp. 2017 Jan;38(1):472-492. doi: 10.1002/hbm.23397. PubMed PMID: 27634551; PubMed Central PMCID: PMC5217095.