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Pediatric Blood and Marrow Transplantation & Cellular Therapy
Mayo Mail Code 366
420 Delaware Street SE
Minneapolis, MN 55455
Dr. Lund is interested in the use of hematopoietic stem cell transplantation (HSCT) primarily for patients with inherited metabolic disorders, like Adrenoleukodystrophy (ALD), Hurler syndrome (MPS-1H), Hunter syndrome, Metachromatic Leukodystrophy, and others. He studies the onset of disease, biomarkers of disease, mechanism of disease, and how HSCT improves the disease process. His work both in his research laboratory and with his patients has created many new approaches to treatment, which will ultimately make HSCT safer and more effective.
"Yes, we're saving lives. But that's not enough. I want to improve the quality of life for these kids, and that's where I'm focusing my energy."
Engelen, M., van Ballegoij WJC, Mallack, E. J., Van Haren, K. P., Köhler, W., Salsano, E., van Trotsenburg ASP, Mochel, F., Sevin, C., Regelman, M. O., Tritos, N. A., Halper, A., Lachmann, R. H., Davison, J., Raymond, G. V., Lund, T., Orchard, P. J., Kuehl, J. S., Lindemans, C. A., Caruso, P., Turk, B. R., Moser, A. B., Vaz, F. M., Ferdinandusse, S., Kemp, S., Fatemi, A., Eichler, F. S., Huffnagel, I. C., 2022. International Recommendations for the Diagnosis and Management of Patients With Adrenoleukodystrophy: A Consensus-Based Approach. Neurology,
doi.org/10.1212/WNL.0000000000201374
PubMed ID: 36175155
Gong, J., Liu, Y., Chung, T. H., Xu, L., Lund, T. C., Chang, L. J., 2022. Intracerebral lentiviral ABCD1 gene therapy in an early disease onset ALD mouse model. Gene therapy,
doi.org/10.1038/s41434-022-00355-0
PubMed ID: 35790794
Barclay, E., Ojo, I., Hake, A., Oyenuga, A., Satrom, K., Lund, T., Oyenuga, M., Slusher, T., Gbadero, D., 2022. Neonatal Jaundice: Knowledge and Practices of Healthcare Providers and Trainees in Southwest Nigeria. The American journal of tropical medicine and hygiene,
doi.org/10.4269/ajtmh.21-0588
PubMed ID: 35895425
2022. Hematopoietic cell transplantation for sialidosis type I. Molecular Genetics and Metabolism Reports, 30. doi.org/10.1016/j.ymgmr.2021.100832
PubMed ID: 35242566
Takahashi, T., Illamola, S. M., Jennissen, C. A., Long, S. E., Lund, T. C., Orchard, P. J., Gupta, A. O., Long-Boyle, J. R., 2021. Busulfan dose recommendation in inherited metabolic disorders: Population pharmacokinetic analysis: Busulfan PK model in inherited metabolic disease. Transplantation and cellular therapy, 28 (2): 104.e1-104.e7. doi.org/10.1016/j.jtct.2021.11.018
PubMed ID: 34883294
El Jurdi, N., O'Leary, D., He, F., de For, T., Rashidi, A., Warlick, E., Gupta, A., Maakaron, J., Janakiram, M., Slungaard, A., Smith, A., Bachanova, V., Brunstein, C., MacMillan, M., Miller, J., Betts, B., Ebens, C., Stefanski, H., Lund, T., Orchard, P., Vercellotti, G., Weisdorf, D., Holtan, S., 2021. Low Incidence of Chronic Graft-versus-host Disease in Myeloablative Allogenic Hematopoietic Cell Transplantation with Post-Transplant Cyclophosphamide using Matched Related or Unrelated Donors: Phase II Study Interim Analysis. 63rd American Society of Hematology Annual Meeting and Exposition. 138
doi.org/10.1182/blood-2021-147569
Wiersma, R., Gupta, A. O., Lund, T. C., Orchard, P. J., Miller, B. S., 2021. Adrenal Insufficiency in an Adolescent Boy With Type 1 Diabetes Mellitus - the Importance of Considering X-Linked Adrenoleukodystrophy. ENDO 2021. Journal of Endocrine Society,
Hampe, C. S., Wesley, J., Lund, T. C., Orchard, P. J., Polgreen, L. E., Eisengart, J. B., McLoon, L. K., Cureoglu, S., Schachern, P., McIvor, R. S., 2021. Mucopolysaccharidosis Type I: Current Treatments, Limitations, and Prospects for Improvement. Biomolecules, 11 (2)
doi.org/10.3390/biom11020189
PubMed ID: 33572941
Majovska, J., Nestrasil, I., Paulson, A., Nascene, D., Jurickova, K., Hlavata, A., Lund, T., Orchard, P. J., Vaneckova, M., Zeman, J., Magner, M., Dusek, P., 2020. White matter alteration and cerebellar atrophy are hallmarks of brain MRI in alpha-mannosidosis. Molecular genetics and metabolism,
doi.org/10.1016/j.ymgme.2020.11.008
PubMed ID: 33317989
Srivastava, I., Aguirre, A., Cayrol, R., Lund, T., Vogel, H., Van Haren, K., 2020. A role for NLPR3 inflammasome in demyelinating lesions in cerebral adrenoleukodystrophy. Proceedings of the 16TH INTERNATIONAL CHILD NEUROLOGY VIRTUAL CONGRESS October 2020. JICNA,
Mohan, A., Kenney-Jung, D., Gupta, A. O., Lund, T. C., 2020. Co-Assortment of MPS II (Hunter Disease) and Fragile XE syndrome. Proceedings of the 16TH INTERNATIONAL CHILD NEUROLOGY VIRTUAL CONGRESS October 2020 . JICNA,
Lu, P. N., Moreland, T., Christian, C. J., Lund, T. C., Steet, R. A., Flanagan-Steet, H., 2020. Inappropriate cathepsin K secretion promotes its enzymatic activation driving heart and valve malformation. JCI insight, 5 (20) doi.org/10.1172/jci.insight.133019
PubMed ID: 33055423
Naumchik, B. M., Gupta, A., Flanagan-Steet, H., Steet, R. A., Cathey, S. S., Orchard, P. J., Lund, T. C., 2020. The Role of Hematopoietic Cell Transplant in the Glycoprotein Diseases. Cells, 9 (6): 1411.
doi.org/10.3390/cells9061411
PubMed ID: 32517081
Tipton, P. W., Kenney-Jung, D., Rush, B., Singh, B., Holtan, S., Ayala, E., Broderick, D. F., Lund, T. C., Wszolek, Z. K., Hematopoietic stem cell transplantation: An Effective Treatment for CSF1R-related Leukoencephalopathy. American Academy of Neurology 2021 Annual Meeting, San Fransisco, CA, .
Belur, L., Braunlin, E., Lund, T. C., Huber, A., Mantone, H., Karlen, A., Smith, M., Ou, L., Whitley, C. B., Buss, N., McIvor, R. S., Comparative cardiac, neurologic, and skeletal effectiveness of intravenous and intrathecal AAV9 delivered individually or combined in a murine model of mucopolysaccharidosis type I. ASGCT 24th Annual Meeting.
Hoover, A., O'Leary, D., Cao, Q., Gupta, A., Ebens, C., Maakaron, J., Betts, B., Juckett, M., Lund, T., Bachanova, V., MacMillan, M., Miller, J., Orchard, P., Wagner, J., Vercellotti, G., Weisdorf, D., Dusenbery, K., Terezakis, S., Holtan, S., El Jurdi, N., Phase II Study of Myeloablative 8/8- or 7/8-Matched Allotransplantation with Post-Transplant Cyclophosphamide, Tacrolimus, and Mycophenolate Mofetil: Marked Reduction in GVHD Risk Without Increase Relapse Risk Compared to Historical Cyclosporine/Methotrex. ASH, December 10 2022, New Orleans, LA. American Society of Hematology,
Firoozmand, A., O'Leary, D., Cao, Q., Gupta, A., Ebens, C., Maakaron, J., Betts, B., Lund, T., Bachanova, V., MacMillan, M., Miller, J., Orchard, P., Wagner, J., Vercellotti, G., Weisdorf, D., Dusenbery, K., Terezakis, S., Holtan, S., El Jurdi, N., Juckett, M., Allogeneic Hematopoietic Stem Cell Transplantation Using Reduced Intensity Conditioning with Cyclophosphamide/ Fludarabine/2 Gy Total Body Irradiation (TBI) preparative regimen with Tacrolimus, MMF with or without ATG for the Treatment of Hematological Ma. ASH, December 10 2022, New Orleans, LA. American Society of Hematology,
Long, S. E., Lund, T. C., Gupta, A. O., Boelens, J., Orchard, P. J., Bodyweight/ absolute lymphocyte count based dosing of Anti-Thymocyte Globulin (ATG) results in early CD4+ immune reconstitution in patients with inborn errors of metabolism undergoing umbilical cord blood transplantation. ASH, December 10 2022, New Orleans, LA. American Society of Hematology,
Drozdov, D., Long, S. E., Gupta, A. O., Lund, T. C., Boelens, J., Orchard, P. J., Bodyweight and absolute lymphocyte count based dosing of rabbit anti-thymocyte globulin results in early cd4+ immune reconstitution in patients with inborn errors of metabolism undergoing umbilical cord blood transplantation. Transplantation & Cellular Therapy Meetings of ASTCT and CIBMTR, February 15-19, 2023, Orlando, Florida. American Society of Transplant and Cellular Therapy,
Dr. Lund's research focuses improving the outcomes for all patients undergoing blood and marrow transplantation by increasing the speed at which hematopoietic stem cells reconstitute the immune system after transplant. He also works to increase our understanding the pathophysiological processes underlying inherited metabolic diseases. One area Dr. Lund is exploring is how an autoimmune reaction may trigger the cerebral form of adrenoleukodystrophy (cALD), the most serious form of ALD. This study represents the largest screening for immune-reactivity in cALD ever performed, and further research could help identify ALD patients with immune-reactivity prior to the onset of cALD.
Pediatrics, American Board of Pediatrics
Pediatric Hematology-Oncology, American Board of Pediatric
Minneapolis-St. Paul Top Doctor, Minneapolis-St. Paul Magazine
Team Science Award, Department of Pediatrics, University of Minnesota
Basic Science Paper of the Year (Assistant Professor), Department of Pediatrics, University of Minnesota
Butterfly Award for Outstanding Medical Research, Children’s Cancer Research Fund
1st Place Outstanding Achievement in Research, Fellow/Margaret Kendrick Hostetter Award
Lund, T. C. "HCT Outcomes for Childhood Cerebral ALD", 2022 United Leukodystrophy Foundation (ULF) Family Meeting. June 24, 2022.
Lund, T. C., Kaczmarcyk, A., Lasio, L. D., Viskochil, S., Longo, N., Orchard, P., Yang, A., Chang, I., C., H., Aliu, E., Siemon, A., Mori, M., Dickson, P., Al-Hertani, W., Ahrens-Nicklas, R., Pasquali, M. "Analysis of urine heparan sulfate and its non-reducing ends for the follow-up of abnormal newborn screening for Analysis of urine heparan sulfate and its non-reducing ends for the follow-up of abnormal newborn screening for MPS1", SIMD 43rd annual meeting, Society for Inherited Metabolic Disorders, Orlando, Florida. April 10, 2022.
Lund, T. C. "Men with cALD - Treatment Options", ALD Connect Boot Camp - Men with AMN, ALD Connect. June 12, 2021.
Takahashi, T., Illamola, S., Jennissen, C., Long, S. E., Lund, T. C., Orchard, P. J., Long-Boyle, J., Gupta, A. O. "Busulfan Dose Recommendation in Inherited Metabolic Disorders: Population Pharmacokinetic Analysis", PRESS 2021, University of Minnesota Department of Pediatrics, Minneapolis, Minnesota. April 23, 2021.
Lund, T. C. "The Blood-Brain Barrier and Hematopoietic Stem Cell Transplant", Virtual 26th Annual Blood-Brain Barrier Consortium, Neuro-Oncology and BBB Program at Oregon Health & Science University (OHSU). March 11, 2021.
Gimbel, B., Gupta, A. O., Lund, T. C., Eisengart, J. B. "Does extending enzyme replacement therapy after transplant provide neurocognitive benefit in Hurler syndrome?", 17th Annual WORLD Symposium, San Diego, California. February 10, 2021.
Lund, T. C., Belur, S. R., Huber, A., Mantone, H., Smith, M., Podetz-Pedersen, K., Karlen, A., Braunlin, E. A., Robinson, N., Tsai, H., McIvor, R. S., Bonner, M. "Effect of supraphysiological alpha-L-iduronidase (IDUA) expression on skeletal manifestations in mucopolysaccharidosis type I (MPS I) mice following ex vivo lentiviral vector transduction of hematopoietic stem cells", 17th Annual WORLD Symposium. February 09, 2021.
Lund, T. C., Polgreen, L. E., Braunlin, E. A., Dickson, P., Tolar, J., Gupta, A. O., Chen, A., Orchard, P. J., Eisengart, J. "Biochemical predictors of neurocognitive outcomes in Hurler syndrome", 17th Annual WORLD Symposium. February 09, 2021.
Pillai, N., Orchard, P. J., Lund, T. C., Ahrens-Nicklas, R., Andang, L., Elsea, S. H., Whitley, C. B. "Evaluation of the Effectiveness of Bone Marrow Transplantation in Multiple Sulfatase Deficiency", 17th Annual WORLD Symposium, San Diego, California. February 09, 2021.
Lund, T. C. "A (fish)Tale on Two Continents, G6PD biology", Global Health Research Series, University of Minnesota, Minneapolis, Minnesota. January 29, 2021.
Lund, T. C., (Presenter) "BMT for ALD: Who is going to do well?", ULF Meeting 2020, United Leukodystrophy Foundation, Saint Paul. June 27, 2020.
Van Haren, K., Bonkowsky, J., Lund, T. C., Parker, A. "Panel: Future Therapies - gene therapy for cerebral ALD, gene therapy for AMN, small molecule therapy", ALD Family Weekend 2020. May 03, 2020.
Lund, T. C., Eichler, F. "Debate - Stem Cell Transplant versus Gene Therapy for X-ALD (with Troy Lund and Florian Eichler)", EBMT IEWP Annual Educational Meeting, London, United Kingdom. October 11, 2019.
Lund, T. C. "Zebrafish and U", Undergraduate Backstage Pass Event, University of Minnesota, Minneapolis, Minnesota. January 01, 2013.
Clinical Interests
Adrenoleukodystrophy; Bone marrow transplant; Hurler syndrome; Peripheral blood stem cell transplant; Umbilical cord blood transplant