Mark Osborn
,
Credentials
PhD

Assistant Professor, Division of Pediatric Blood and Marrow Transplantation & Cellular Therapy
Faculty, Department of Pediatrics
Research Scientist, Pediatric Blood and Marrow Transplant (BMT) Center
Faculty, Masters Program in Stem Cell Biology
Biography

Bio

Dr. Osborn is an Assistant Professor in the Department of Pediatrics, Division of Blood and Marrow Transplantation. He is also a member of the Cancer Center. Dr. Osborn received his PhD degree from the University of Minnesota in 2009 in the laboratory of Dr. Bruce R. Blazar, MD.

Research Summary

Dr. Osborn's current research is focused on gene and cellular therapy for disorders treated by hematopoietic cell transplantation including: Fanconi anemia, epidermolysis bullosa, and Hurler syndrome. This involves utilizing a patient's own cells for precision gene targeting and correction of their disease causing mutation. Genome editing nucleases and multiple terminally differentiated and stem cell populations are utilized towards optimizing ex vivo cellular therapies.
Gene Therapy
- Non-viral gene transfer for the treatment of inborn errors of metabolism.
Genome Editing
- Correction of disease specific mutations in a precise manner using homologous recombination.
Cellular Therapy
- Ex vivo correction of murine and human adult stem cells.

Education

PhD in Microbiology Biology, Immunology & Cancer Biology, University of Minnesota, Minneapolis, MN

Honors and Recognition

Best abstract award, Pediatrics Research, Education, and Scholarship Symposium (PRESS), University of Minnesota Medical School
Meet the Investigator profile, Journal of Investigative Dermatology
Children’s Cancer Research Fund Butterfly Award, Medical Category
Basic Science Paper of the Year Award, Department of Pediatrics, University of Minnesota
Innovator in Basic Science Award, Department of Pediatrics, University of Minnesota

Professional Memberships

Member, American and European Societies for Gene and Cellular Therapy
Contact

Contact

Address

Pediatric Blood and Marrow Transplantation & Cellular Therapy
Mayo Mail Code 366
420 Delaware Street SE
Minneapolis, MN 55455

Administrative Contact

Elizabeth Soderberg
Administrative Phone: 612-625-8319
Administrative Email: soder348@umn.edu
Administrative Fax Number: 612-626-4074