Paul Orchard, MD

Dr. Paul Orchard is the Medical Director of the Inherited Metabolic and Storage Disease Program and a Professor in the Department of Pediatrics, Division of Blood and Marrow Transplant & Cellular Therapy. Dr. Orchard's focus is in the use of hematopoietic stem cell transplantation and other cell therapies for inherited metabolic disorders, with a special interest in the inherited leukodystrophies, the mucopolysaccharidoses and osteopetrosis. His clinical research is in evolving new and combination therapies to decrease toxicity and improve outcomes, with a particular interest in the use of gene therapy approaches.

• Team Science Award, Department of Pediatrics, University of Minnesota (2019)
• Minneapolis - St. Paul Magazine “Top Doctors” (2012-2018, 2020, 2021)
• Best Doctors in America® (2011-2012, 2013)
• Recipient, Jundt Research Award (1998-2000)
• Recipient, Amy Strelzer-Manasevit Scholar's Award (1 of 2 National Awards)
• Amy Strelzer-Manasevit Scholar’s award (1998-2000)
• Recipient, American Cancer Society Career Development Award (1994-1996)

• Hematopoietic Cell Transplantation of Genetic Disorders Transplant related toxicity and graft failure Use of reduced intensity preparative regimens Risk factors affecting outcomes following transplantation
• Osteopetrosis Biology and genetics of osteopetrosis Correlations of clinical and genetic parameters to outcome and prognosis Hematopoietic transplantation and other therapies
• Gene Therapy T cell engineering with "suicide genes" for transplantation Infusions of mismatched T cells with following genetic manipulation Treatment of genetic and metabolic diseases with gene therapy
• Development of Alternative Cellular Therapy Use of mesenchymal stem cells for genetic diseases Infusions of immunologically active cell populations