Paul Orchard, MD

Dr. Paul Orchard is the Medical Director of the Inherited Metabolic and Storage Disease Program and a Professor in the Department of Pediatrics, Division of Blood and Marrow Transplantation. Dr. Orchard's focus is in the use of hematopoietic stem cell transplantation and other cell therapies for inherited metabolic disorders, with a special interest in the inherited leukodystrophies, the mucopolysaccharidoses and osteopetrosis. His clinical research is in evolving new and combination therapies to decrease toxicity and improve outcomes, with a particular interest in the use of gene therapy approaches.

• Team Science Award, Department of Pediatrics, University of Minnesota (2019)
• Minneapolis - St. Paul Magazine “Top Doctors” (2012-2018)
• Best Doctors in America® (2011-2012, 2013)
• Recipient, Jundt Research Award (1998-2000)
• Recipient, Amy Strelzer-Manasevit Scholar's Award (1 of 2 National Awards)
• Amy Strelzer-Manasevit Scholar’s award (1998-2000)
• Recipient, American Cancer Society Career Development Award (1994-1996)

• Hematopoietic Cell Transplantation of Genetic Disorders Transplant related toxicity and graft failure Use of reduced intensity preparative regimens Risk factors affecting outcomes following transplantation
• Osteopetrosis Biology and genetics of osteopetrosis Correlations of clinical and genetic parameters to outcome and prognosis Hematopoietic transplantation and other therapies
• Gene Therapy T cell engineering with "suicide genes" for transplantation Infusions of mismatched T cells with following genetic manipulation Treatment of genetic and metabolic diseases with gene therapy
• Development of Alternative Cellular Therapy Use of mesenchymal stem cells for genetic diseases Infusions of immunologically active cell populations