Paul Orchard, MD
Professor, Department of Pediatrics

Contact Info
Professor, Department of Pediatrics
Faculty Member, Division of Pediatric Blood and Marrow Transplantation & Cellular Therapy Program
BMT Specialist, Pediatric Blood and Marrow Transplant (BMT) Center
Director, Mucopolysaccharidosis (MPS) Center
Team Member, Leukodystrophy Center
Pediatric Blood and Marrow Transplant Physician
MD, Brown University Hospital, Providence RI
Residency in Pediatrics, University of Wisconsin Hospital, Madison, WI
Fellowship in Hematology-Oncology and Blood and Marrow Transplantation, University of Minnesota Medical School, Minneapolis, MN
Summary
Dr. Paul Orchard is the Medical Director of the Inherited Metabolic and Storage Disease Program and a Professor in the Department of Pediatrics, Division of Blood and Marrow Transplant & Cellular Therapy. Dr. Orchard's focus is in the use of hematopoietic stem cell transplantation and other cell therapies for inherited metabolic disorders, with a special interest in the inherited leukodystrophies, the mucopolysaccharidoses and osteopetrosis. His clinical research is in evolving new and combination therapies to decrease toxicity and improve outcomes, with a particular interest in the use of gene therapy approaches.
Awards & Recognition
Research
Research Summary/Interests
- Hematopoietic Cell Transplantation of Genetic Disorders Transplant related toxicity and graft failure Use of reduced intensity preparative regimens Risk factors affecting outcomes following transplantation
- Osteopetrosis Biology and genetics of osteopetrosis Correlations of clinical and genetic parameters to outcome and prognosis Hematopoietic transplantation and other therapies
- Gene Therapy T cell engineering with "suicide genes" for transplantation Infusions of mismatched T cells with following genetic manipulation Treatment of genetic and metabolic diseases with gene therapy
- Development of Alternative Cellular Therapy Use of mesenchymal stem cells for genetic diseases Infusions of immunologically active cell populations
Clinical
Specialties
- Pediatric Blood and Bone Marrow Transplant
- Pediatrics
Clinics
Journey Clinic - Center for Pediatric Blood and Marrow Transplantation
Board Certifications
American Board of Pediatrics; American Board of Hematology/Oncology
Clinical Interests
Bone marrow transplants to treat genetic diseases; Osteopetrosis; Inherited conditions
Hospital Privileges
M Health Fairview Masonic Children's Hospital; University of Minnesota Medical Center