Radha Rajasingham, MD

Assistant Professor of Medicine, Division of Infectious Diseases and International Medicine

Radha Rajasingham

Contact Info

Mailing Address:
420 Delaware ST SE
Room D416 Mayo Memorial Building
MMC 250
Minneapolis, MN 55455

Administrative Assistant Name
IDIM Admin

Administrative Phone

Administrative Email

Administrative Fax Number

Assistant Professor of Medicine, Division of Infectious Diseases and International Medicine

Cryptococcal Meningitis, HIV

Medical School, University of Minnesota, Minneapolis, MN

Residency, Beth Israel-Deaconess Medical Center, Boston, MA

Fellowship, Beth Israel-Deaconess Medical Center, Boston, MA


Awards & Recognition


Research Summary/Interests

  • Implementation and Cost-effectiveness of Point-of-care Diagnostics
  • Cryptococcal Screening and Prevention
  • Cryptococcal Meningitis


  • Nalintya E, Meya DB, Lofgren S, Hullsiek KH, Boulware DR, Rajasingham R. A prospective evaluation of a multisite Cryptococcal screening and treatment program in HIV clinics in Uganda. JAIDS. 2018
  • Mpoza E, Mukaremera L, Kundura DA, Akarmpurira A, Luggya T, Tadeo KK, Pastick KA, Bridge SC, Tugume L, Kiggundu R, Musubire AK, Williams DA, Muzoora C, Nalintya E, Rajasingham R, Rhein J, Boulware DR, Meya DB, Abassi M. Evaluation of a point-of-care immunoassay test kit ‘StrongStep’ for cryptococcal antigen detection. PLOS One. 2018 Jan 5;13(1).
  • Beyene T, Zewde AG, Balcha A, Hirpo B, Yitbarik T, Gebissa T, Rajasingham R, Boulware DR. Inadequacy of high-dose fluconazole monotherapy among cerebrospinal fluid cryptococcal antigen (CRAG) positive HIV-infected persons in an Ethiopian CRAG screening program. Clin Infect Dis. 2017 Nov 29;65(12):2126-2129.
  • Rajasingham R, Pollock NR, Linas BP. The Cost-effectiveness of a Point-of-Care paper transaminase test for monitoring treatment of HIV/TB Co-infected persons. Open Forum Infectious Diseases. 2017 Oct 1; 4(4).
  • Rajasingham R, Smith RM, Park BJ, Jarvis JN, Govender NP, Chiller TM, Denning DW, Loyse A, Boulware DR. Global burden of disease of HIV-associated cryptococcal meningitis: an updated analysis.Lancet Infect Dis. 2017 Aug; 17(8): 873-881.Rajasingham R, Meya DB, Boulware DR. Are fluconazole or sertraline dose adjustments necessary with concomitant rifampin. HIV Med. 2017 Aug 1.
  • Montgomery, MP; Nakasujja N, Morawski BM, Rajasingham R, Rhein J, Nalintya E, Williams DA, Hullsiek KH, Kiragga A, Rolfes MA, Carlson RD, Bahr NC, Birkenkamp KE, Manabe YC, Bohjanen PR, Kaplan JE, Kambugu A, Meya DB, Boulware DR.. Neurocognitive function in HIV-infected persons with asymptomatic cryptococcal antigenemia. BMC Neurology. 2017 June 1; 17(1).
  • Ramachandran A, Manabe Y, Rajasingham R, Shah M. Cost-effectiveness of CRAG-LFA screening for cryptococcal meningitis among people living with HIV in Uganda. BMC Infect Dis. 2017 Mar 23;17(2):225.
  • Flynn AG, Meya DB, Hullsiek KH, Rhein J, Williams DA, Musubire A, Morawski BM, Taseera K, Sadiq A, Ndyatunga L, Roediger M, Rajasingham R, Bohjanen PR, Muzoora C, Boulware DR. Evolving failures in the delivery of human immunodeficiency virus care: Lessors from a Ugandan meningitis cohort 2006-2016. Open Forum Infectious Diseases. 2017 Mar 1: 4(2).
  • Lofgren S, Hullsiek KH, Morawski BM, Nabeta HW, Kiggundu R, Taseera K, Musubire A, Schutz C, Abassi M, Bahr NC, Tugume L, Muzoora C, Williams DA, Rolfes MA, Velamakanni SS, Rajasingham R, Meintjes G, Rhein J, Meya DB, Boulware DR; COAT and ASTRO-CM Trial Teams. Differences in immunologic factors among patients presenting with altered mental status during cryptococcal meningitis.J Infect Dis. 2017 Jan 30.
  • Vidal JE, Toniolo C, Paulino A, Colombo A, Dos Anjow Martins M, da Silva Meira C, Pereira-Chioccola VL, Figueiredo-Mello C, Barros T, Duarte J, Fonseca F, Alves Cunha M, Mendes C, Ribero T, Dos Santos Lazera M, Rajasingham R, Boulware DR. Asymptomatic cryptococcal antigen prevalence detected by lateral flow assay in hospitalized HIV-infected patients in Sao Paulo, Brazil. Trop Med Int Health. 2016 Dec;21(12):1539-1544. 
  • Rolfes MA, Rhein J, Schutz C, Taseera K, Nabeta HW, Huppler Hullsiek K, Akampuira A, Rajasingham R, Musubire A, Williams DA, Thienemann F, Bohjanen PR, Muzoora C, Meintjes G, Meya DB, Boulware DR. Cerebrospinal Fluid Culture Positivity and Clinical Outcomes After Amphotericin-Based Induction Therapy for Cryptococcal Meningitis. Open Forum Infect Dis. 2015 Dec 28;2(4).
  • Bahr NC, Tugume L, Rajasingham R, Kiggundu R, Williams DA, Morawski B, Alland D, Meya DB, Rhein J, Boulware DR. Improved diagnostic sensitivity for tuberculous meningitis with Xpert MTB/Rif of centrifuged CSF. Int J Tuberc Lung Dis. 2015 Oct;19(10):1209-15.
  • Jain S*, Rajasingham R*, Noubary F, Coonahan E, Schoeplein R, Baden RP, Curry M, Afdhal N, Kumar S, Pollock NR. Performance of an Optimized Paper-based Test for Rapid Visual Measurement of Alanine Aminotransferase (ALT) in Fingerstick and Venipuncture Samples. *These authors contributed equally to this work. PLoS One. 2015 May 28;10(5).
  • Rajasingham R, Boulware DR. HIV Care: ART adherence support and cryptococcal screening. Lancet. 2015 May 30;385(9983):2128-9.
  • Meya D, Rajasingham R, Nalintya E, Tenforde M, Jarvis JN. Preventing Cryptococcosis –Shifting the Paradigm in the Era of Highly Active Antiretroviral Therapy. Curr Trop Med Rep. 2015;2(2):81-89.
  • Rajasingham R, Rhein J, Klammer K, Musubire A, Nabeta H, Akampurira A, Mossel EC, Williams DA, Boxrud DJ, Crabtree MB, Miller BR, Rolfes MA, Tengsupakul S, Andama AO, Meya DB. Epidemiology of Meningitis in an HIV-infected Ugandan Cohort. Am J Trop Med Hyg. 2015 Feb 4;92(2):274-9.
  • Kwizera R, Nguna J, Kiragga A, Nakavuma J, Rajasingham R, Boulware DR, Meya CB. Performance of cryptococcal antigen lateral flow assay using saliva in Ugandans with CD4<100. PLoS One. 2014 Jul 31;9(7).
  • Rolfes MA, Hullsiek KH, Rhein J, Nabeta HW, Taseera K, Schutz C, Musubire A, Rajasingham R, Williams DA, Thienemann F, Muzoora C, Meintjes G, Meya DB, Boulware DR. The Effect of Therapeutic Lumbar Punctures on Acute Mortality from Cryptococcal Meningitis. Clin Infect Dis. 2014 Jul 23.
  • Boulware DR, Meya DB, Muzoora C, Rolfes MA, Huppler Hullsiek K, Musubire A, Taseera K, Nabeta HW, Schutz C, Williams DA, Rajasingham R, Rhein J, Thienemann F, Lo MW, Nielsen K, Bergemann TL, Kambugu A, Manabe YC, Janoff EN, Bohjanen PR, Meintjes G. Timing of antiretroviral therapy after diagnosis of cryptococcal meningitis. N Engl J Med. 2014 Jun 26;370(26):2487-98.
  • Rajasingham R, Williams D, Meya DB, Meintjes G, Boulware DR, Scriven J. Nosocomial drug-resistant Bacteremia in 2 cohorts with Cryptococcal Meningitis, Africa. Emerg Infect Dis. 2014 Apr;20(4):722-4.
  • Boulware DR, Rolfes MA, Rajasingham R, von Hohenberg M, Qin Z, Taseera K, Schutz C, Kwizera R, Butler EK, Meintjes G, Muzoora C, Bischof JC, Meya DB. Multisite Validation of Point-of-Care Cryptococcal Antigen Lateral Flow Assay and Novel Quantification by Laser Thermal Contrast Measurement. Emerg Infect Dis. 2014 Jan 20(1):45-53.
  • Donahue Carlson R, Rolfes MA, Birkenkamp KE, Nakasujja N, Rajasingham R, Meya DB, Boulware DR. Predictors of Neurocognitive Outcomes on Antiretroviral Therapy after Cryptococcal Meningitis: a prospective cohort study. Metab Brain Dis. 2014 Jun;29(2):269-79.
  • Rajasingham R, Rolfes M, Birkenkamp K, Meya DB, Boulware DR. Cryptococcal Meningitis Treatment Strategies in Resource-Limited Settings: A Cost-Effectiveness Analysis. PLoS Medicine. 2012 Sep; 9 (9):e1001316.
  • Rajasingham R, Boulware DR. Reconsidering Cryptococcal Antigen Screening in the US among persons with a CD4<100 cells/mcL. Clin Infect Dis. 2012 Dec; 55(12):1742-4.
  • Rajasingham R, Meya DB, Boulware DR. Integrating Cryptococcal Antigen Screening and Pre-Emptive Treatment into Routine HIV Care. J Acquir Immune Defic Syndr. 2012 Apr 15; 59(5):85-91.
  • Rajasingham R, Mimiaga MJ, Pinkston-Camp MM, Baden RP, Mitty JA. A systematic review of behavioral and treatment outcome studies among HIV-infected men who have sex with men who abuse crystal methamphetamine. AIDS Patient Care and STDs. 2012 Jan; 26(1):36-52.



  • Infectious Disease
  • Internal Medicine


Delaware Street Clinic (Infectious Disease/HIV Clinic)

Board Certifications

  • Internal Medicine
  • Infectious Diseases

Clinical Interests

HIV; PREP; Global Health