Clinical Research Studies and Trials

Our clinical research studies are aimed at evaluating a medical, surgical, or behavioral intervention. They are the primary way that researchers find out if a new treatment, a new drug, diet or medical device is safe and effective. 

Epidemiology of Diabetes Intervention and Complications (EDIC)

The Epidemiology of Diabetes Intervention and Complications (EDIC) study is a multicenter, observational study designed to follow the type 1 diabetic volunteers who participated in the Diabetes Control and Complications Trial (DCCT). EDIC is now in its 23rd year of follow-up.

FIDELIO

The purpose of this study is to evaluate whether finerenone is effective and safe in treating patients with type 2 diabetes and Diabetic Kidney Disease in addition to regular therapy. Type 2 diabetes is a chronic disease in which the body is unable to properly use insulin, a hormone that regulates blood sugar levels, or does not produce enough insulin, typically leading to increased blood sugar levels and other complications.

FIGARO

The purpose of this study is to evaluate whether finerenone is effective and safe in reducing the incidence of cardiovascular events in patients with type 2 diabetes and diabetic kidney disease. Type 2 diabetes is a chronic disease in which the body is unable to properly use insulin, a hormone that regulates blood sugar levels, or does not produce enough insulin, typically leading to increased blood sugar levels and other complications. 

GRADE

To Determine which Combination of Two Medications is Best for Glycemic Control, has the Fewest Side Effects, and is the most Beneficial for Overall Health.

Hypoglycemia Studies

Preventing hypoglycemia after exercise can be difficult. The purpose of this study is to learn if naloxone can be used to treat exercise-related hypoglycemia symptoms. Naloxone is currently used as a substance abuse treatment medication but research studies have shown it to possibly be effective in preventing next-day hypoglycemia.

PERL

PERL stands for Preventing Early Renal Function Loss in Diabetes. The PERL study is a three-year multi-center study aiming to determine whether allopurinol can reduce loss of renal function in people with type 1 diabetes. 

REWIND

To see whether the Investigational Drug Dulaglutide, can Safely Reduce the Development of Serious Heart Disease or Stroke in People with Type 2 Diabetes - R.

Resuscitation Clinical Research

Resuscitation science is a developing sub-specialty of Interventional Cardiology under the leadership of Demetri Yannopoulos, MD. The focus of this center is to conduct research that focuses on all aspects of resuscitation from sudden cardiac arrest.

Train Me Up Acute Exercise Substudy

To Investigate how Acute Exercise may Alter Muscle Metabolism.

Train Me Up MN

To Investigate how Exercise might Alter Fitness and Improve Metabolism before and after a Running or Yoga Routine.

White Matter Structure

To Investigate the Effects of Diabetes and its Treatments on Brain Metabolism and Function.

ClinicalTrials.gov

ClinicalTrials.gov is a database of privately and publicly funded clinical studies conducted around the world.