Zohar Sachs Lab
![Zohar Sachs](/sites/med.umn.edu/files/images/untitled_artwork_75.png)
The Sachs Lab's goal is to identify molecular mechanisms of leukemia stem cell self-renewal in acute myeloid leukemia (AML). Since AML cells are highly heterogeneous, we specialize in the application of single-cell, high throughput technologies (including mass cytometry/CyTOF and single-cell RNA sequencing) and patient-derived xenografts and genetically engineered mouse models to address these research questions. We believe that this approach will identify effective therapeutic targets for this deadly disease.
![zohar](/sites/med.umn.edu/files/zohar-lab.jpg)
Celebrating cancer 'ResearcHERS' and addressing the challenges
Sachs Lab Members
![Image of Sach's Lab Members](/sites/med.umn.edu/files/sachs-banner.png)
Sachs lab presenting new research findings (“Cell type-specific effects of crizotinib in human acute myeloid leukemia with TP53 alterations”) at the 2019 society for hematology (ASH) annual meeting in Orlando, FL.
Left to right: Jeff Jensen, MD/PhD (former post-doc), Marie Lue Antony, PhD (post-doc), Klara Noble-Orcutt, MS (lab manager), and Zohar Sachs, MD/PhD (principal investigator)
![Image of Marie Lue Antony](/sites/med.umn.edu/files/images/antony-marie-lue-sachs-lab.png)
Marie Lue Antony, PhD, Research Associate
Research Interests: Cancer stem cells, AML
Current Research: Therapeutic targeting of leukemia stem cells in AML; understanding the therapeutic vulnerabilities of TP53 altered AML
![Image of Yoonkyu (Ryan) Lee](/sites/med.umn.edu/files/images/lee-yoonkyu-sachs-lab.png)
Yoonkyu (Ryan) Lee, Graduate Student, PhD Candidate, Bioinformatics and computational biology program (BICB)
Research Interests: Cancer, single cell RNA-seq, genomics and machine learning
Current Research: I am developing new computational methods to analyze single cell RNA sequencing data to discover new features and dependencies of self-renewal
Education: BS, Biochemistry, University of Wisconsin (2016)
Email: leex5085@umn.edu
![Image of Daniel Chang](/sites/med.umn.edu/files/images/chang-daniel.png)
Daniel Chang, Graduate Student, PhD Candidate, Bioinformatics and computational biology program (BICB)
Research Interests: Applying machine learning methods to single-cell RNA sequencing data, cancer stem cell self-renewal mechanisms, and statistical modeling of signaling
Current Research: Using a myelodysplastic syndromes (MDS) mouse model to study the transformation from MDS to secondary acute myeloid leukemia.
Education: BS, Microbiology, University of Minnesota (2013)
![Image of Klara Noble-Orcutt](/sites/med.umn.edu/files/images/noble-orcutt-klara-sachs-lab.png)
Klara Noble-Orcutt, MS, Lab Manager
Research Interests: Cancer stem cells, murine models of leukemia
Current Research: Defining therapeutic vulnerabilities in treatment resistant AML using patient-derived xenografts
Education: BS, MS, University of Minnesota
Email: noble116@umn.edu
Contact
Zohar Sachs, MD, PhD
Assistant Professor
Division of Hematology, Oncology, and Transplantation
Department of Medicine
University of Minnesota
Contact
Sarah Strommer
strom721@umn.edu