John Belcher Lab

Dr. John Belcher's research is focused on hemoglobin, heme, and iron toxicity to the endothelium, as well as related cytoprotective responses. Currently, he is investigating heme-mediated inflammation, vaso-occlusion, and pain in sickle cell anemia through toll-like receptor-4 signaling and complement activation. His research is also exploring the cytoprotective effects of hemopexin, BACH1 inhibitors, heme oxygenase-1 inducers, oral carbon monoxide, and complement inhibitors as therapies to prevent vascular occlusions and pain in sickle cell disease. Sickle Cell Disease Endothelial Cells including Circulating Endothelial Cells Vascular Biology Innate Immunity and Inflammation Gene Therapy for Sickle Cell Disease Fetal Hemoglobin Induction.

Collaboration Vecellotti and Belcher labs since 1990's