Gianluigi Veglia
,
Credentials
PhD
Credentials
PhD
Professor
Biography
Research Summary
The Veglia Lab focuses on two critical aspects of cell regulation: cAMP-mediated cell signaling and calcium transport. These events are orchestrated by soluble and membrane-bound protein complexes. To characterize their structure, dynamics, and interactions, we utilize a multidisciplinary approach combining solution and solid-state NMR spectroscopy with other biophysical methods. Our goal is to understand how these protein complexes mediate allosteric signal transduction in cells and how pathological mutations of these proteins are linked to diseases.
Education
PhD,
University of Rome, Italy - “La Sapienza”
Major: Chemistry
Languages
Italian
Selected Presentations
Selected Presentations
Veglia, G.
"Regulins control SERCA via Topological Allostery",
International Council on Magnetic Resonance in Biological Systems,
ICMRBS,
September 01, 2020.
Veglia, G.
"Allosteric Regulation of Ca2+ transport into the sarcoplasmic reticulum by SERCA/phospholamban complex",
Albert Einstein College of Medicine,
Bronx,
New York,
November 01, 2017.
Veglia, G.
"Allosteric Regulation of Ca2+ transport into the sarcoplasmic reticulum by SERCA/phospholamban complex",
Florida State University,
Tallahassee,
Florida,
November 01, 2017.
Veglia, G.
"Regulated folding-unfolding of phospholamban cytoplasmic domain controls Ca2+-ATPase function",
9th Inhibitors of Protein Kinases Conference,
Warsaw,
Poland.
September 01, 2017.
Veglia, G.
"Regulated folding-unfolding of phospholamban cytoplasmic domain controls Ca2+-ATPase function",
International Symposium on Protein Misfolding Diseases,
Catania,
Italy.
August 01, 2017.
Veglia, G.
"Solid-State NMR Spectroscopy Reveals the Allosteric Regulation of the Sarcoplasmic Reticulum",
ISMAR 2017,
Quebec,
Canada.
July 01, 2017.
Veglia, G.
"Solid-State NMR Spectroscopy Reveals the Allosteric Regulation of the Sarcoplasmic Reticulum",
American Peptide Symposium,
Whistler,
Canada.
June 01, 2017.
Veglia, G.
"Solid-State NMR Spectroscopy Reveals the Allosteric Regulation of the Sarcoplasmic Reticulum",
Canadian Chemistry Conference and Exhibition,
Toronto,
Canada.
May 01, 2017.
Veglia, G.
"The role of conformational dynamics in cAMP-dependent protein kinase A: implications in function and disease",
North Dakota State University,
Fargo,
North Dakota,
April 01, 2017.
Veglia, G.
"The role of conformational dynamics in cAMP-dependent protein kinase A: implications in function and disease",
Stony Brook University,
Stony Brook,
New York,
April 01, 2017.
Veglia, G.
"Intramolecular Signaling in Protein Kinase A via Hydrophobic Motifs: Implications for Allosteric Binding Cooperativity",
University of Michigan-Ann Arbo,
December 01, 2016.
Veglia, G.
"Intramolecular Signaling in Protein Kinase A via Hydrophobic Motifs: Implications for Allosteric Binding Cooperativity",
University of Texas-San Antonio,
December 01, 2016.
Veglia, G.
"Intramolecular Signaling in Protein Kinase A via Hydrophobic Motifs: Implications for Allosteric Binding Cooperativity",
University of South Florida,
September 01, 2016.
Veglia, G.
"Role of conformational dynamics in the canonical and non-canonical functions of kinases",
University of Chicagonov,
November 01, 2015.
Veglia, G.
"Allosteric Regulation of the Sarcoplasmic Reticulum Ca2+-ATPase by Phospholamban and Sarcolipin using Solid-State NMR Spectroscopy",
University of Strasbourg,
October 01, 2015.
Veglia, G.
"Dynamic Signatures of Active and Inhibited Protein Kinase A using NMR Spectroscopy",
University of Strasbourg,
October 01, 2015.
Veglia, G.
"Correlation Between Conformational Dynamics, Activity, and Regulation in Protein Kinase A",
University of Strasbourg,
October 01, 2015.
Veglia, G.
"Allosteric Regulation of the Sarcoplasmic Reticulum Ca2+-ATPase by Phospholamban and Sarcolipin using Solid-State NMR Spectroscopy",
University of Strasbourg,
October 01, 2015.
Veglia, G.
"Allosteric Regulation of the Sarcoplasmic Reticulum Ca2+-ATPase by Phospholamban and Sarcolipin using Solid-State NMR Spectroscopy",
University of Strasbourg,
October 01, 2015.
Veglia, G.
"Role of conformational dynamics in the canonical and non-canonical functions of kinases",
University of Strasbourg,
October 01, 2015.
Veglia, G.
"Dynamic Signatures of Active and Inhibited Protein Kinase A using NMR Spectroscopy",
Experimental Nuclear Magnetic Resonance Conference,
April 01, 2015.
Veglia, G.
"Allosteric Regulation of the Sarcoplasmic Reticulum Ca2+-ATPase by Phospholamban and Sarcolipin using Solid-State NMR Spectroscopy",
Michigan State University,
March 01, 2015.
Veglia, G.
"Allosteric Regulation of the Sarcoplasmic Reticulum Ca2+-ATPase by Phospholamban and Sarcolipin using Solid-State NMR Spectroscopy",
University of Kansas,
February 01, 2015.
Veglia, G.
"Allosteric Regulation of the Sarcoplasmic Reticulum Ca2+-ATPase by Phospholamban and Sarcolipin using Solid-State NMR Spectroscopy",
Annual Biophysical Society Meeting,
February 01, 2015.
Veglia, G.
"Allosteric Regulation of the Sarcoplasmic Reticulum Ca2+-ATPase by Phospholamban and Sarcolipin using Solid-State NMR Spectroscopy",
Aarhus University,
January 01, 2015.
Veglia, G.
"'Multiple Acquisitions of Magic Angle Spinning Solid-state NMR Experiments Using One Receiver: Application to microcrystalline and membrane Proteins",
Chicago Area NMR Discussion,
November 01, 2014.
Veglia, G.
"Solid-state NMR of Membrane Protein Complexes",
Chicago Area NMR Discussion Group,
November 01, 2014.
Veglia, G.
"Correlation Between Conformational Dynamics, Activity, and Regulation in Protein Kinase A",
Columbia University,
October 01, 2014.
Veglia, G.
"cAMP-dependent Protein Kinase A Regulation of Cardiac Muscle Contractility",
Albert Einstein College of Medicine,
October 01, 2014.
Veglia, G.
"Allosteric Regulation of the Sarcoplasmic Reticulum Ca2+-ATPase by Phospholamban and Sarcolipin using Solid-State NMR Spectroscopy",
ICMRBS,
August 01, 2014.
Veglia, G.
"Solid-State NMR of Multispan Membrane Proteins and Membrane Protein Complexes",
Rocky Mountain Conference on Magnetic Resonance,
July 01, 2014.
Veglia, G.
"Allosteric Regulation of the Sarcoplasmic Reticulum Ca2+-ATPase by Phospholamban and Sarcolipin using Solid-State NMR Spectroscopy",
University of Illinois,
May 01, 2014.
Veglia, G.
"Correlation between conformational dynamics and activity in protein kinase A",
American Society for Biochemistry and Molecular Biology Meeting,
April 01, 2014.
Veglia, G.
"Allosteric Regulation of the Sarcoplasmic Reticulum Ca2+-ATPase by Phospholamban and Sarcolipin using Solid-State NMR Spectroscopy",
McMaster University,
March 01, 2014.
Veglia, G.
"Allosteric Regulation of the Sarcoplasmic Reticulum Ca2+-ATPase by Phospholamban and Sarcolipin using Solid-State NMR Spectroscopy",
University of Toronto,
March 01, 2014.
Veglia, G.
"Optimization of NMR experiments for Oriented and Magic Angle Spinning Experiments on Membrane Proteins",
NMR Meets Biology,
February 01, 2014.
Veglia, G.
"Allosteric Regulation of the Sarcoplasmic Reticulum Ca2+-ATPase by Phospholamban and Sarcolipin using Solid-State NMR Spectroscopy",
NMR Meets Biology,
Tata Institute of Fundamental Research,
February 01, 2014.
Veglia, G.
"Optimization of NMR experiments for Oriented and Magic Angle Spinning Experiments on Membrane Proteins",
NMR Meets Biology,
Tata Institute of Fundamental Research,
February 01, 2014.
Veglia, G.
"Biological NMR and Molecular Dynamics",
Structural Biology, Biomaterials and Bioengineering Workshop,
January 01, 2014.
Veglia, G.
"Protein Kinase A and Conformational Dynamics: Not too Fast, Not too Slow, but Just Right",
The City College of New York,
October 01, 2013.
Veglia, G.
"Allosteric Regulation of the Sarcoplasmic Reticulum Ca2+-ATPase by Phospholamban and Sarcolipin using Solid-State NMR Spectroscopy",
University of Massachusetts,
September 01, 2013.
Veglia, G.
"Allosteric Regulation of the Sarcoplasmic Reticulum Ca2+-ATPase by Phospholamban and Sarcolipin using Solid-State NMR Spectroscopy",
EUROMAR 2013,
June 01, 2013.
Veglia, G.
"Protein Kinase A Conformational Dynamics; Not Too Fast, Not Too Slow, Just Right",
International Society of Magnetic Resonance Meeting,
May 01, 2013.
Veglia, G.
"Conformational Equilibrium of Membrane Protein Complexes by Oriented and MAS NMR Spectroscopy",
Experimental Nuclear Magnetic Resonance Conference, ,
April 01, 2013.
Veglia, G.
"Probing the conformational equilibrium of membrane protein complexes by oriented and MAS NMR Spectroscopy",
University of Cambridge,
March 01, 2013.
Veglia, G.
"Molecular Details of SERCA Regulation by Phospholamban Revealed by Paramagnetic Relaxation Enhancements and Solid-State NMR",
Annual Biophysics Society Meetingfeb,
February 01, 2013.
Veglia, G.
"Structural Analysis of Ca2+ regulation in the cardiac muscle: from understanding to control",
University of Texas-Southwestern,
October 01, 2012.
Veglia, G.
"Protein Kinase Dynamics: Not too slow, not too fast…but just right!",
International Lecture in Biochemistry,
October 01, 2012.
Veglia, G.
"Structural Analysis of Calcium Regulation in Muscle",
International Lecture in Biochemistry,
October 01, 2012.
Veglia, G.
"Protein Kinase A Conformational Dynamics; Not Too Fast, Not Too Slow, Just Right",
University of California-San Diego,
August 01, 2012.
Veglia, G.
"Structural Analysis of Calcium Regulation in Muscle: From Understanding to Control",
Methods in Protein Structure Analysis,
June 01, 2012.
Veglia, G.
"Protein Kinase A Conformational Dynamics; Not Too Fast, Not Too Slow, Just Right",
University of Viterbo,
June 01, 2012.
Veglia, G.
"Structural Analysis of Calcium Regulation in Muscle: From Understanding to Control",
FASEB Summer Research Conference,
June 01, 2012.
Veglia, G.
"Protein Kinase A Conformational Dynamics; Not Too Fast, Not Too Slow, Just Right",
University of Minnesota,
June 01, 2012.
Veglia, G.
"Structural Analysis of Calcium Regulation in Muscle: From Understanding to Control",
Yale University,
April 01, 2012.
Veglia, G.
"Structural Analysis of Calcium Regulation in Muscle: From Understanding to Control",
Iowa State University,
April 01, 2012.
Veglia, G.
"Solid-State NMR of Membrane Protein Complexes",
17th Meeting of the National Magnetic Resonance Society of India,
February 01, 2012.
Veglia, G.
"Structural Analysis of Calcium Regulation in Muscle: from Understanding to Control",
University of Wisconsin-Madison,
November 01, 2011.
Veglia, G.
"NMR of Ground and Excited States of Membrane Proteins",
Ohio State University,
November 01, 2011.
Veglia, G.
"Structural Analysis of Calcium Regulation in Muscle",
Rutgers University,
October 01, 2011.
Veglia, G.
"Mapping Allostery in Protein Kinase A by NMR Spectroscopy",
Telluride Science Research Center,
August 01, 2011.
Veglia, G.
"Can Structural Biology Help the Rational Design of Gene Therapy?",
Cardiovascular Retreat, Saint John’s University,
June 01, 2011.
Veglia, G.
"Solid-State NMR of Membrane Proteins",
University of St. Thomas,
February 01, 2011.
Veglia, G.
"NMR of Ground and Excited States of Membrane Proteins",
PACIFICHEM 2010,
December 01, 2010.
Veglia, G.
"NMR of Ground and Excited States of Membrane Proteins",
University of Kansas,
November 01, 2010.
Veglia, G.
"NMR of Ground and Excited States of Membrane Proteins",
University of Arkansas,
September 01, 2010.
Veglia, G.
"NMR of Ground and Excited States of Membrane Proteins",
International Conference on Magnetic Resonance in Biological Systems,
August 01, 2010.
Veglia, G.
"Role of Dynamics in Substrate Recognition, Catalysis, and Inhibition of Protein Kinase A",
Toward a Meaningful Analysis of Phosphoryl Transfers and RNA Catalysis: Experiments and Computation, Telluride Science Research Center,
June 01, 2010.
Veglia, G.
"Characterization of Ground and Excited States of Membrane Proteins by Hybrid Solution and Solid-State NMR Methods",
EUROMAR 2010,
June 01, 2010.
Veglia, G.
"Hybrid Solution and Solid-State NMR Approach to Determine the High-Resolution Structure and Topology of Membrane Proteins",
16th Meeting of the National Magnetic Resonance Society of India,
February 01, 2010.
Veglia, G.
"Role of Dynamics in Substrate Recognition, Catalysis, and Inhibition of Protein Kinase A",
University of Cambridge,
January 01, 2010.
Veglia, G.
"Role of Dynamics in Substrate Recognition, Catalysis, and Inhibition of Protein Kinase A",
University of California-San Diego,
November 01, 2009.
Veglia, G.
"Hybrid Solution and Solid-State NMR Approach to Determine the High-Resolution Structure and Topology of Membrane Proteins",
University of North Carolina,
November 01, 2009.
Veglia, G.
"Hybrid Solution and Solid-State NMR Approach to Determine the Structural Topology of Membrane Proteins",
University of Guelph,
August 01, 2009.
Veglia, G.
"Use of Affinity Tag Technology for Isotopic Labeling of Membrane Peptides and Proteins for NMR Analysis",
Cabridge Healthtech Institute,
August 01, 2009.
Veglia, G.
"NMR portrait of Allostery and Cooperativity in Protein Kinase A",
Protein Society Meeting,
July 01, 2009.
Veglia, G.
"Structural Biology of Muscle Contractility",
University of Chieti,
June 01, 2009.
Veglia, G.
"NMR Analysis of PKA Recognition of Soluble Membrane-Bound Substrates",
ICAM,
December 01, 2008.
Veglia, G.
"Hybrid Solution and Solid-State NMR Methods for Membrane Protein Structure Determination",
University of Pennsylvania,
November 01, 2008.
Veglia, G.
"Hybrid Solution and Solid-State NMR Methods for Membrane Protein Structure Determination",
University of Nebraska,
October 01, 2008.
Veglia, G.
"Hybrid Solution and Solid-State NMR Methods for Membrane Protein Structure Determination",
The Ohio State University,
October 01, 2008.
Veglia, G.
"Hybrid Solution and Solid-State NMR Methods for Membrane Protein Structure Determination",
18th Solid-State NMR Workshop,
July 01, 2008.
Veglia, G.
"Hybrid Solution and Solid-State NMR Methods for Membrane Protein Structure Determination",
Gordon Conference-Computational Aspects of Biomolecular NMR,
May 01, 2008.
Veglia, G.
"april",
University of Virginia,
April 01, 2008.
Veglia, G.
"Hybrid Solution and Solid-State NMR Methods for Membrane Protein Structure Determination",
ENC-Varian User Meeting,
March 01, 2008.
Veglia, G.
"Controlling the Inhibition of the Sarcoplasmic Ca2+-ATPase by Tuning Phospholamban Structural Dynamics",
Annual Biophysics Society Meeting,
February 01, 2008.
Veglia, G.
"Structural Biology of Cardiac Muscle Contraction and Relaxation: From Understanding to Control",
Georgia Tech,
February 01, 2008.
Veglia, G.
"NMR Profile of PKA Catalytic Subunit",
University of California-San Diego,
August 01, 2007.
Veglia, G.
"Hybrid Solution and Solid-State NMR Methods for Membrane Protein Structure Determination",
Chianti NMR Workshop,
March 01, 2007.
Veglia, G.
"Structural Biology of Muscle Contraction and Relaxation",
University of Florence,
March 01, 2007.
Veglia, G.
"Structure, Dynamics, and Interactions of Integral Membrane Proteins by Solid-State NMR",
Frontiers of NMR Keystone Conference,
January 01, 2007.
Veglia, G.
"Probing Membrane Protein-Protein Interactions by NMR Spectroscopy",
University of Pittsburgh,
November 01, 2006.
Veglia, G.
"NMR Spectroscopy as a Tool for the Structural Analysis of Membrane Proteins Involved in Muscle Contraction and Relaxation",
Georgia Tech,
November 01, 2006.
Veglia, G.
"NMR Structural Dynamics of Membrane Proteins Involved in Muscle Contraction and Relaxation",
GRASP-NMR,
October 01, 2006.
Veglia, G.
"Structural Dynamics and Interactions of Type-I Membrane Proteins Using Solid-State NMR",
GIDRM,
September 01, 2006.
Veglia, G.
"NMR Spectroscopy as a Tool for the Structural Analysis of Membrane Proteins Involved in Muscle Contraction and Relaxation",
University of Padua,
September 01, 2006.
Veglia, G.
"Structure, Dynamics, Topology and Interactions of Monotopic Membrane Proteins in Aligned Lipid Bilayers by Solid-State NMR",
17th Solid-State NMR Workshop,
July 01, 2006.
Veglia, G.
"NMR Reveals the Allosteric Regulation of SERCA by the Integral Membrane Protein Phospholamban",
McMaster University,
June 01, 2006.
Veglia, G.
"NMR analysis of the inhibitory mechanism of Ca-ATPase by Sarcolipin and Phospholamban",
1st International Workshop on Expression, Structure, and Function of Membrane Proteins,
June 01, 2006.
Veglia, G.
"Interactions Between Membrane Proteins by NMR",
Florida State University,
May 01, 2006.
Veglia, G.
"Probing Intramembrane Protein-Protein Interactions by Solid-State NMR Spectroscopy",
PACIFICHEM 2005,
December 01, 2005.
Veglia, G.
"What Can We Learn From the Structural Studies of Antimicrobial Peptides in Detergent Micelles?",
Membrane Biophysics of Antimicrobial Peptides,
September 01, 2005.
Veglia, G.
"NMR Structural and Dynamics studies of the C-subunit of Protein Kinase A complexed to PKI",
ICAM: Sponsored Meeting: Frontiers of Science: Signal Transduction and Protein Phosphorylation,
July 01, 2005.
Veglia, G.
"Structure, Dynamics, and Interactions of Membrane Proteins by Solution and Solid-State NMR",
Protein Dynamics Workshop,
January 01, 2005.
Veglia, G.
"NMR Reveals the Allosteric Regulation of SERCA by the Integral Membrane Protein Phospholamban",
University of Miami,
December 01, 2004.
Veglia, G.
"Probing the Interactions Between Integral Membrane Proteins Using Magnetic Resonance Spectroscopy",
Michigan State University,
October 01, 2004.
Veglia, G.
"Probing the Interactions Between Integral Membrane Proteins Using Magnetic Resonance Spectroscopy",
15th ISMAR Conference,
October 01, 2004.
Veglia, G.
"NMR of Membrane Proteins: Structural Analysis of Calcium Regulation in Cardiac Muscle",
University of Minnesota,
September 01, 2004.
Veglia, G.
"Combining Solution NMR, Solid-State NMR, and EPR to study the Structure, Dynamics, and Interactions of Membrane Proteins",
American Chemical Society Regional Meeting,
June 01, 2004.
Veglia, G.
"NMR Probes of Calcium Transport Regulation",
Biophysical Society Meeting,
February 01, 2004.
Veglia, G.
"Inhibition of Ca2+-ATPase by Phospholamban: New Insights into the Cardiac Muscle Contractility",
Mayo Clinic,
January 01, 2004.
Veglia, G.
"Structure, Dynamics, and Function of the Membrane Protein Stannin",
Membrane Biophysics Symposium at the University of Michigan,
December 01, 2003.
Veglia, G.
"NMR Approaches to Study Membrane Protein Structure and Interactions",
College of St. Benedict,
November 01, 2003.
Veglia, G.
"NMR Structure and Interactions of Stannin: A Small Membrane Protein that Regulates Apoptosis",
University of Tuscia,
June 01, 2003.
Veglia, G.
"Structure and Interactions of Membrane Proteins by NMR Spectroscopy",
CBITG Symposium,
May 01, 2003.
Veglia, G.
"Structure-Function Relationships of the Ca2+-ATPase Regulators Phospholamban and Sarcolipin: Toward the Characterization of Intramembrane Interactions by NMR Spectroscopy",
Biophysical Society Annual Meeting,
March 01, 2003.
Veglia, G.
"Residual Dipolar Couplings for Use in NMR Structure Determination of Membrane Proteins",
Frontiers of NMR Keystone Conference,
February 01, 2003.
Veglia, G.
"NMR Analysis of Protein-Mediated Metal Transport Through the Membranes",
American Chemical Society Great Lakes Regional Meeting,
June 01, 2002.
Veglia, G.
"Structure and Membrane Orientation of Sarcolipin and Phospholamban: New Insights into Cardiac and Skeletal Muscle",
American Chemical Society Regional Meeting,
June 01, 2002.
Veglia, G.
"Protein-Mediated Mercury, Calcium and Tin transport through Membranes",
Chemical Biology Colloquium,
April 01, 2002.
Veglia, G.
"Structure-Function Relationships of Membrane-Bound Regulatory Polypeptides",
University of Minnesota,
March 01, 2002.
Veglia, G.
"Protein-Mediated Ion Transport Through Membranes: A Structural View",
Burnham Institute,
March 01, 2002.
Veglia, G.
"The Role of Structural Biology in the Environmental Problems and in Human Diseases",
Lawrence College,
June 01, 2001.
Veglia, G.
"On the Role of Solution and Solid-State NMR in the Structure Determination of Membrane Protein",
University of Minnesota,
September 01, 2000.
Veglia, G.
"Solution and Solid-State NMR of Membrane Protein Involved in Calcium Regulation",
Minnesota NMR Users Group Meeting,
September 01, 2000.
Veglia, G.
"Solution and Solid-State NMR Approaches to Solve Membrane Protein Structure",
University of Rome,
April 01, 1999.
Veglia, G.
"NMR Spectroscopy of Membrane Proteins",
International School for Advanced Studies,
November 01, 1998.
Veglia, G.
"Structural Biology of the Bacterial Mercury Transport System",
University of Florence,
August 01, 1998.
Veglia, G.
"Structural studies of Membrane Proteins by Solution and Solid-State Multidimensional NMR",
University of Rome,
June 01, 1997.
Veglia, G.
"Triple-labeled Protein NMR Analysis at High-Field",
The Seventh Mid-Atlantic Bruker Symposium,
October 01, 1996.
Contact
Contact
Address
5-132 NHHMinneapolis, MN 55455