Department Heads

Bio

Dr. Chen is an internationally recognized brain tumor researcher and surgeon, with a dedicated interest in understanding how glioblastomas acquire resistance to radiation and chemotherapy. He is an NIH RO1-funded investigator whose research focuses on developing novel diagnostic and therapeutic approaches for brain tumor patients. He is also a leader in the study of DNA repair and gene therapy in brain tumors. His laboratory is housed in the University of Minnesota Masonic Cancer Center.

The recipient of several highly competitive research awards, Dr. Chen has won the:

• Damon Runyon Fellowship Award
• Sidney Kimmel Scholar Award
• Burroughs Wellcome Foundation Career Award in Medical Sciences
• Sontag Foundation Distinguished Scientist Award, the Doris Duke Foundation Clinical Scientist Award
• Forbeck Scholar Award.

In 2016, Dr. Chen received the Presidential Award of Achievement from the President of Taiwan, Ma Ying-jeou. The award is given annually by the Taiwanese government to individuals of Taiwanese heritage who have made exceptional contributions to their profession.

Education

• MD, Harvard Medical School, 2001
• Neurosurgery, Massachusetts General Hospital, 2002-2007
• Post-doctoral Fellow, Department of Radiation Oncology, Dana Farber Cancer Institute, 2006
• Clinical Fellow, Radiosurgery, Department of Radiation Oncology, Massachusetts General Hospital, 2009
• Clinical Fellow, Stereotactic Neurosurgery, Division of Neurosurgery, Beth Israel Deaconess Medical Center, 2009
• PhD, Genetics, Harvard Medical School, 1999
• MS, Epidemiology, Columbia University, 1993
• BS, Stanford University, 1992

Professional Associations

• American Association of Neurological Surgeons
• Congress of Neurological Surgeons
• American Association for Cancer Research
• American Association for the Advancement of Science
• Society of Neuro-Oncology
• International Brain Mapping and Intraoperative Surgical Planning Society
• American Society for Radiation Oncology

Board Certifications

American Board of Neurological Surgeons

In the Media

2-2020: Minnesota Physician: Glioblastoma: Activating an immune response
12-4-19: Minnesota Daily: New campus MRI machine to expand surgery capability
11-20-19:

• KARE11: U of M pioneers new 'T-suite' surgical room
• M Health Fairview: State-of-the-art Neurosurgery Suite a "Giant Leap Forward" for Brain Cancer, Movement Disorder Treatment

10-4-19: The "Goldilocks" Principle for Curing Brain Cancer
7-24-19:

• KARE11: 7.2-Ton Magnet Lifted to U of M Hospital
• KSTP: First in the World Intraoperative MRI Surgical Suite at U of M Medical Center
• FOX9: New MRI Machine at U of M to Help with Surgeries of Tomorrow

6-27-19: New drug helps surgeons spot brain tumors by turning them pink
1-27-19: Minnesota-developed NeuroBlate device saves brain cancer patients. But what's next?
12-3-18: U Doctor Examining How Laser Brain Surgery Affects Peoples' Lives
11-7-18: U of M begins trial for new brain cancer treatment
8-24-18: University of Minnesota Dr. on why McCain likely stopped his cancer treatment
8-24-18: High-profile glioblastoma deaths may be no coincidence
5-29-18: Doctor, patient reunited years after lifesaving surgery
1-8-18: Breakthrough Surgery Uses Laser To Remove Minnesota Man's Brain Tumor.
 

Executive Assistant:

Sally Sawyer
Administrative Phone: 612-624-6666 (hit 4 for the Academic Office)
Administrative Email: sallyann@umn.edu
Administrative Fax Number: 612-624-0644

Research Summary

Dr. Chen is a nationally recognized brain tumor researcher and surgeon, with a dedicated interest in understanding how glioblastomas acquire resistance to radiation and chemotherapy. He is an NIH RO1-funded investigator with research focused on developing novel diagnostic and therapeutic approaches for brain tumor patients. He is also a leader in the study of DNA repair and gene therapy in brain tumors.

View PubMed List

Clinical Summary

Brain tumors; minimally invasive cranial surgery; laser thermal ablation; endoscopy; oncolytic virus delivery; tractography-guided surgery; awake craniotomy

Bio

Dr. Clohisy is a professor and chair of the Department of Orthopedic Surgery at the University of Minnesota and a member of the University of Minnesota Cancer Center. He specializes in musculoskeletal oncology with a focus on both primary and metastatic cancers of bone and the management of musculoskeletal problems in hemophilia.

His clinical research focuses on the effect of surgical treatment of skeletal metastasis on health status, and he has also researched the cellular mechanisms of tumor osteolysis and mechanisms of bone cancer pain. He is committed to advancing all levels of musculoskeletal education and has interest and experience in developing both outstanding community orthopedic surgeons and orthopedic clinician scientists. His research program has had NIH funding for 23 consecutive years and he currently leads an Academic Health Center NIH training grant for graduate and past doctoral students.

Expertise

• Orthopedics
• Cancer

Awards & Recognition

• Best Doctors in America®: 2007-2010, 2011-2012, 2013
• Mpls.St. Paul Magazine "Top Doctors:" 2009-2010, 2012-2015, 2020
• U.S. News & World Report Top Doctor: 2012
• Minnesota Monthly "Top Doctors:" 2014, 2018, 2020

Publications

View Dr. Clohisy's Publications on PubMed

Professional Associations

• Chair of the Department of Orthopedic Surgery
• Elected member of the University of Minnesota Physicians (UMP) Board of Directors, serves on the UMP Executive committee and Chairs the UMP Clinical Strategies Committee
• Member, American Board of Orthopaedic Surgery Board Exam Committee
• Member, American Orthopaedic Association Critical Issues Committee
• Member, American Academy of Orthopaedic Surgeons Communicative Cabinet and Council on Education.

Research Summary

Research Interests

• Bone and Soft Tissue Neoplasms
• Osteolysis
• Osteoclasts
• Mouse Genetic Engineering
• Bone Cancer Pain
• Experimental Sarcoma Models

Clinical Summary

My passion is bringing cutting-edge techniques, compassion, and hope to orthopedic oncology patients and their families. I listen to my patient’s needs and work with them to create a care plan tailored to their unique situation. I enjoy getting to know my patients and improving their quality of life.

Board Certifications

American Board of Orthopaedic Surgery

Clinical Specialties

• Musculoskeletal oncology with focus on both primary and metastatic cancers of the bone
• Management of musculoskeletal problems in hemophilia

Clinical Interests

Musculoskeletal oncology with focus on both primary and metastatic cancers of the bone; Management of musculoskeletal problems in hemophilia

Hospital Privileges

University of Minnesota Masonic Children's Hospital; University of Minnesota Medical Center

Research Summary

Neurophysiology of cerebellum and motor cortex. Our laboratory is trying to understand how single neurons and populations of neurons encode the information needed to plan and execute limb movements. Our goal is to decipher how the brain represents different movement parameters and then uses this information to control movements. We are investigating both kinematic and dynamic movement parameters, recording the activity of neurons in the cerebellum and cerebral cortex in primates during motor behaviors. A variety of movements are studied, including reaching to targets in space, tracking moving targets, the learning of new visuomotor relations, and hand movements. Using analytical and statistical techniques, we sort out how information about movement parameters is embedded in the neuronal discharge.At a higher level of integration, we are interested in how information in the brain is represented spatially and temporally in populations of neurons. In the cerebellum we are using flavoprotein fluorescence and Ca++ dyes to visualize neural activity. Using epifluorescence and multi-photon imaging, we are able to construct detailed spatial and temporal maps of the neuronal activity in the cerebellar cortex. One major question is to understand the spatial patterns of activity generated during behavior. We are also using optical imaging to examine the abnormalities in the cerebellar cortex in the spinocerebellar and episodic ataxias.

Bio

Dr. Fischer earned his medical degree at Uniformed Services University of the Health Sciences and completed Residency training at Wright State and Urogynecology Fellowship training at Indiana University. He has served in numerous leadership roles including Urogynecology Fellowship Director, Ob/Gyn Residency Director and served as the Department Chief of one of the largest Ob/Gyn departments in the Department of Defense. He is currently serving as Faculty for APGO's Surgical Scholars Course and as an Oral Board Examiner, ABOG. He was honored to be named the Professor of the Year by the Junior Fellows of Armed Forces District of American College of Obstetricians and Gynecologists. His research interests include the effects of pregnancy, labor, and delivery on the pelvic floor and surgical education.

Dr. Fischer transitioned from a 29-year career as an Air Force physician to start a new Division of Female Pelvic Medicine and Reconstructive Surgery in the Department of Obstetrics, Gynecology and Women's Health. He began his new role in October 2017 and his clinical practice sites will include Women's Health Specialists Clinic and M Health Clinics & Surgery Center.

Administrator Information

Brenda Olson
Administrative Phone: 612-626-3111
Administrative Email: ols00323@umn.edu

Clinical Summary

Schedule an Appointment:
Minneapolis - M Health Fairview Women's Clinic - Riverside: 612-273-7111
M Health Fairview Clinics & Surgery Center: 612-273-8383
M Health Fairview Center for Women - Edina: 952-285-6140
 

Bio

Leo T. Furcht is Allen-Pardee Professor and Head of the Department of Laboratory Medicine and Pathology at the University of Minnesota and a member of the Division of Molecular Pathology and Genomics. He served as Chairman of the Board of Directors for University of Minnesota Physicians, the Medical School practice plan with approximately 700 physicians, from 2004-2014. For a three-year period in the 90's he served as Vice Provost for Research of the University of Minnesota Health Sciences and established a research services organization to provide turnkey solutions for faculty and companies to facilitate clinical trials. Furcht served as the President of the Federation of American Societies for Experimental Biology (FASEB) a biomedical research advocacy organization with over 125,000 members and 23 constituent societies from 2006-2007. Prior to this he served as Vice President for Science Policy and led a FASEB program on conflict of interest in biomedical research. Furcht was also founding director of the Biomedical Engineering Center and led early efforts focused on biomedical MEMS, stem cells and molecular diagnostics. He was also founding director MD/ PhD program at the University of Minnesota and was principal investigator of the initial grant from the National Institutes of Health (NIH) Medical Scientist Training Program for the MD/PhD program. He played the lead role in establishing a highly regarded Center for Immunology at the University of Minnesota. Early in his career Furcht received a Research Career Development Award from the NIH and later a NCI Merit award.Furcht served on two American Association of Medical Colleges / American Association of Universities Task Forces working on issues surrounding academia industry interactions and issues regarding medical education and clinical research. He has testified in Congressional hearings on NIH budget re-authorization, before Institute of Medicine committees on scientific issues including embryonic stem cell research and a Presidential commission on the dual use of biological organisms. Furcht has published more than 175 scientific papers and holds more than 30 patents in the fields of polypeptides, biomaterials, and adult stem cells. He was profiled in the Medical School's Impact Medicine campaign under the title "Dr. Leo Furcht Creates a Legacy Many Aspire to Achieve."

Research Summary

Research Summary/Interests

• tumor cell behavior and metastasis
• extracellular matrix proteins and receptors
• stem cells
• biotechnology

Publications

• Hoffman, W. and Furcht, L. Divergence, convergence, and innovation: East-West bioscience in an anxious age.Asian Biotechnology and Development Review 16 (3): 3-23, 2014.
• Hoffman, W. and Furcht, L.T. The Biologist’s Imagination: Innovation in the Biosciences (New York: Oxford University Press, 2014).
• Furcht, L.T., and Hoffman, W. The Stem Cell Dilemma, second edition (New York: Arcade Publishing, 2011).
• DeLarco, J.E., Park, C.A., Dronava, H., Furcht, L.T. Cancer Biol. Ther. 9(5):362-70, 2010.
• Furcht, L.T., and Hoffman, W. Stem Cells. Minnesota Health Care News, 7(3), March 2009.
• Furcht, L.T., and Hoffman, W. The Stem Cell Dilemma (New York: Arcade Publishing, 2008).
• Furcht, L.T. and Wolinetz, C.D. What cures will we miss? The effects of reduced funding for biomedical research. Minnesota Physician, XXI (5), August 2007.
• Brockway LM. and Furcht, L.T. Financial disclosure policies of scientific publications. [Comment letter]. JAMA, 296(4): 2925-6: author reply 2926, 2006.

For a full list of Dr. Furcht's publications, Search PubMed.

Clinical Summary

Specialties

• Cell adhesion molecules and tumor metastasis

Bio

Dr. Haase is Regents’ Professor and Head, Department of Microbiology and Immunology, University of Minnesota. Dr. Haase has devoted his research career from the 1970s to the present to understanding the slow infections caused by lentiviruses from visna virus to SIV and HIV. The Haase lab pioneered approaches to visualizing animal lentivirus and HIV infections in vivo to reveal HIV lymphoid tissue reservoirs; covert infections enabling persistence despite immune defenses and ART; mechanisms of CD4 T cell depletion that limit immune reconstitution; and transmission mechanisms that lay foundations for developing effective microbicides and vaccines. His lab is currently exploring the role of productive and latent infections in resting CD4 T cells during ART with the aim of better Rx to move us closer to a functional cure for HIV infection. Dr. Haase is a NIH NINDS Javits Awardee and two-time recipient of an NIH MERIT Award for his work on HIV, an elected member of the National Academy of Medicine and American Academy of Microbiology, and a Fellow of the AAAS. He has served on the NIH Councils of NIAID and OAR, as the first Chair of the AIDS Research Advisory Council, and as Chair of the US Delegation for the U.S. Japan Cooperative Medical Sciences Program.

Research Summary

Viral pathogenesis, HIV My laboratory investigates the pathogenesis, treatment and prevention of lentiviral immunodeficiency infections caused by HIV-1 and its simian relative, SIV, using such technologies as in situ hybridization, in situ tetramer staining and quantitative image analysis to visualize infection and the hosts' cellular immune response in tissues. Much of our recent work has focused on sexual mucosal transmission and the acute stage of SIV infection, the roles of "resting" and activated CD4 T cells in establishing infection, and the mechanisms of the massive depletion of CD4 T cells in the gut. Going forward, these studies provide a foundation for studies of the correlates of protection for attenuated vaccines, and the development of vaccines and microbicides to prevent transmission. My laboratory has also undertaken a comprehensive microarray analysis of HIV-1 and SIV infections with the objectives of understanding pathogenesis and identifying novel targets for treatment and prevention. Current efforts focus on broadening the microarray analysis to encompass the early through late stages of HIV-1 infection, and mapping genes identified in the analysis to gain insight into their function in HIV-1 infected lymphatic tissues, the principal sites of virus production, persistence and pathology.

Recent Publications:

1. Kroon E, Chottanapund S, Buranapraditkun S, Sacdalan C, Colby DJ, Chomchey N, Prueksakaew P, Pinyakorn S, Trichavaroj R, Vasan S, Manasnayakorn S, Reilly C, Helgeson E, Anderson J, David C, Zulk J, de Souza M, Tovanabutra S, Schuetz A, Robb ML, Douek DC, Phanuphak N, Haase A, Ananworanich J, Schacker TW. Paradoxically Greater Persistence of HIV RNA-Positive Cells in Lymphoid Tissue When ART Is Initiated in the Earliest Stage of Infection. J Infect Dis. 2022 Jun 15;225(12):2167-2175. doi: 10.1093/infdis/jiac089. PMID: 35275599; PMCID: PMC9200151.
2. Wietgrefe SW, Duan L, Anderson J, Marqués G, Sanders M, Cummins NW, Badley AD, Dobrowolski C, Karn J, Pagliuzza A, Chomont N, Sannier G, Dubé M, Kaufmann DE, Zuck P, Wu G, Howell BJ, Reilly C, Herschhorn A, Schacker TW, Haase AT. Detecting Sources of Immune Activation and Viral Rebound in HIV Infection. J Virol. 2022 Aug 10;96(15):e0088522. doi: 10.1128/jvi.00885-22. Epub 2022 Jul 20. PMID: 35856674; PMCID: PMC9364797.
3.  Luca Schifanella, Jodi Anderson, Garritt Wieking, Peter J Southern, Spinello Antinori, Massimo Galli, Mario Corbellino, Alessia Lai, Nichole Klatt, Timothy W Schacker, Ashley T Haase, The Defenders of the Alveolus Succumb in COVID-19 Pneumonia to SARS-CoV-2 and Necroptosis, Pyroptosis, and PANoptosis, The Journal of Infectious Diseases, 2023;, jiad056, https://doi.org/10.1093/infdis/jiad056
4. Wu G, Zuck P, Goh SL, Milush JM, Vohra P, Wong JK, Somsouk M, Yukl SA, Shacklett BL, Chomont N, Haase AT, Hatano H, Schacker TW, Deeks SG, Hazuda DJ, Hunt PW, Howell BJ. Gag p24 Is a Marker of Human Immunodeficiency Virus Expression in Tissues and Correlates With Immune Response. J Infect Dis. 2021 Nov 16;224(9):1593-1598. doi: 10.1093/infdis/jiab121. PMID: 33693750; PMCID: PMC8599810.

Bio

I am a systems neuroscientist with over 30 years of research, teaching, and mentoring experience. Born and raised near Cologne, Germany, I started my academic education in Biology at the University of Mainz, Germany. Later, I moved to the University of Tübingen in southern Germany to focus on Neuroscience, where I completed my masters and PhD thesis at the Max-Planck-Institute for Biological Cybernetics. After a brief year as a postdoctoral fellow at Washington University in St. Louis, USA, I first accepted a faculty position at the University of Freiburg, Germany, then moved to the University of Tennessee Health Science Center in Memphis, TN, USA, and finally accepted the position of Head of the Department for Biomedical Sciences in Duluth, MN.

Research Summary

Principal areas of research center on the structure and function of the cerebellar cortical network, cerebro-cerebellar interaction, dynamics of inter-areal neuronal communication, influence of breathing on brain activity and function in healthy and diseased brains. 

No brain area operates in isolation. Short- and long-range connections form complex networks that enable brain areas to collaborate in a context-dependent manner, responding to internal and external cues to promote survival optimizing behavior. The neocortex and the cerebellum are two key players in this concert. They are reciprocally connected via massive fiber bundles and have both jointly and proportionately increased in size during vertebrate evolution. One focus of our research is to investigate the neuronal mechanisms of cerebro-cerebellar interaction to understand the involvement of the cerebellum in cognitive functions in healthy brains and the link between cerebellar neuropathology and cognitive disorders such as autism and schizophrenia. 

Our second research focus is on the role of breathing in organizing brain activity through respiration-coupled neuronal rhythms. We were the first to report that breathing, via olfactory bulb activity, rhythmically modulates neuronal activity in the neocortex outside of the olfactory system. Our results also showed that the power of high-frequency (40-100Hz) gamma oscillations is modulated in phase with breathing. Gamma oscillations are strongly implicated with cognitive function, which led us to suggest that breathing may directly influence cognitive functions. Brain-breath coupling has since developed into a rapidly growing new research field. Our focus continues to be on the neuronal mechanisms underlying respiratory modulation of neuronal activity in different brain areas, implications of brain-breath coupling for cognitive functions, mental health, and the development of breath-based treatments. 

Teaching Summary

• Curriculum development for graduate programs.
• Course director, lecturer, neuroscience graduate program courses.
• Course director, lecturer, and lab director for neuroanatomy courses for medical and dental students.
• Recipient of Outstanding Lecturer Award from students in the UTHSC College of Dentistry, as course director for Neuroanatomy.
• Nominee for the Student Government Association Executive Council (SGAEC) Excellence in Teaching Award.
• Mentor for three masters and seven PhD students and four postdoctoral fellows.

Bio

If you would like to schedule an appointment with Dr. Hordinsky, please call (612) 625-5656.

Maria K. Hordinsky, M.D. is Professor and Chair of the Department of Dermatology at the University of Minnesota and is also the Director of the Department’s Clinical Research Division. Dr. Hordinsky is recognized for her expertise and research in hair diseases and the peripheral nervous system as it relates to hair follicle biology. She is a member of the Board of Directors of the American Academy of Dermatology and the Scarring Alopecia Foundation. She is also an Immediate Past President of the American Hair Research Society (North, South, Central).

Dr. Hordinsky was a recipient of the Leonard Tow Humanism in Medicine Award and has over 200 publications. She regularly lectures and teaches on hair diseases and divides her time between seeing patients with residents and medical students in her clinical practice associated with University of Minnesota Physicians, doing clinical research, teaching, and administration.

Teaching Summary

Director, UMMC Dermatology clinical rotation for 3rd and 4th year medical students; Hair Disease Research; Mentor to the clinical research fellow at the UMMC site and medical students interested in Dermatology.

Clinical Summary

General dermatology; Hair diseases in children and adults; Genetic dermatology; Cutaneous T cell lymphoma; Neurodermatology; Skin cancer

Bio

Dr. Ikramuddin is the Jay Phillips Professor and Chairman of the Department of Surgery. He completed his medical degree at Albany Medical College, New York, followed by a residency in General Surgery at the State University of New York, Syracuse. Dr. Ikramuddin completed fellowships at Ohio State University in minimally invasive surgery and at the University of Pittsburgh in minimally invasive foregut surgery. He was on staff at the University of Pittsburgh Medical Center, and he was Chief of General Surgery at the VA Medical Center in Pittsburgh until his recruitment to the University of Minnesota in 2001. Dr. Ikramuddin previously held the Robert and Katherine Goodale Chair in Minimally Invasive Surgery. He has a research focus on the outcomes of type 2 diabetes following bariatric surgery and vagal nerve stimulation to produce weight loss. Academically, Dr. Ikramuddin has co-edited a textbook on laparoscopic bariatric surgery, and has authored or co-authored over 125 peer-reviewed publications. He has an interest in basic science research as it relates to the pathogenesis of type 2 diabetes.

Research Summary

The effects of pneumoperitoneum on immunology The pattern of common bile duct healing after surgery Telecommunication systems to enable teleconferencing between remote sites 3-D real-time video holography

Clinical Summary

Minimally invasive general surgery; Effects of gastric bypass on type 2 diabetes mellitus

Bio

The diagnosis of a tumor in the head and neck is daunting for any patient given the possible implications for appearance, speech, and general quality of life. My goal is to establish a foundation of trust and understanding such that my patients fully understand the nature of their disease, the treatment options available, and expected outcomes. I am committed to treating my patients with a combination of well-established therapies and new technology to optimize cure of the disease and quality of life. In addition, microvascular reconstructive techniques are used when appropriate to achieve the goals of optimizing function and form.

Research Summary

I spend my clinical time treating patients with benign and malignant disease of the head neck. Given that this disease is strongly associated with tobacco use, I have become interested in the tobacco-related carcinogenesis and the risk of oral cancer. Specifically, I am driven to produce new and clinically applicable knowledge about the carcinogenic events that lead to oral carcinoma. Many of our patients have a history of smoking, but the factors that cause some smokers to develop carcinoma while others do not are poorly studied. This gap in knowledge led me to study tobacco related carcinogenesis in oral/head and neck cancer. We seek to better understand the specific carcinogens most important in the genesis of oral cancer. This research is expected to not only significantly increase understanding of tobacco-related carcinogenesis, but also aid in risk assessment for oral cancer as well as tobacco regulation efforts.

Publications

• Jain V, Garg A, Parascandola M, Chaturvedi P, Khariwala SS, Stepanov I. Analysis of alkaloids in areca nut-containing products by liquid chromatography-tandem mass-spectrometry. J Agric Food Chem. 2017, DOI: 10.1021/acs.jafc.6b05140
• Wirtz N, Khariwala SS. Should more conservative blood transfusion thresholds be adopted in head and neck surgery? Laryngoscope. 2017, 2017 Mar 14. doi: 10.1002/lary.26560
• Jethwa AR, Khariwala SS. What is the Preferred Perioperative Antibiotic Choice and Duration of Use Following Major Head and Neck Surgery? Laryngoscope. 2017 May;127(5):1009-1010. doi: 10.1002/lary.26427. Epub 2016 Nov 29
• Khariwala SS. Evidence-Based Perioperative Treatment After Free Tissue Reconstruction: Moving From Alchemy to Data.JAMA Otolaryngol Head Neck Surg. 2016 doi:10.1001/jamaoto.2016.3117
• Ma B, Ruszczak C, Jain V, Khariwala SS, Lindgren B, Hatsukami DK,Stepanov I. Optimized Liquid Chromatography Nanoelectrospray-High Resolution Tandem Mass Spectrometry Method for the Analysis of 4-Hydroxy-1-(3-pyridyl)-1-butanone-Releasing DNA Adducts in Human Oral Cells.Chem Res Toxicol. 2016 Nov 21;29(11):1849-1856. Epub 2016 Oct 12 .[Epub ahead of print].
• Sharma A, Patel S, Baik FM, Mathison G, Pierce BHG, Khariwala SS, Yueh B, Schwartz SM, Mendez E. Survival and gastrostomy prevalence in patients with oropharyngeal cancer treated with transoral robotic surgery vs chemoradiotherapy. JAMA Otolaryngol Head Neck Surg. 2016 doi:10.1001/jamaoto.2016.1106
• Khariwala SS, Garg A, Stepanov I, Gupta PC, Ahluwalia JS, Gota V, Chaturvedi P. Point-of-sale tobacco advertising remains prominent in Mumbai, India. Tob Regul Sci. 2016 Jul;2(3):230-238. doi: 10.18001/TRS.2.3.3
• Balbo S, Juanes RC, Khariwala S, Baker EJ, Daunais JB, Grant KA. Increased levels of the acetaldehyde-derived DNA adduct N2-ethyldeoxyguanosine in oral mucosa DNA from Rhesus monkeys exposed to alcohol. Mutagenesis. 2016 Sep;31(5):553-8. doi: 10.1093/mutage/gew016. Epub 2016 Apr 7
• Khariwala SS, Alexander S, Yueh B. Creation and Validation of a Structured Training Program to Train ICU Nurses in Free Flap Monitoring. J Reconst Microsurg Open. 2016 DOI: 10.1055/s-0035-1570534

Clinical Summary

Specialties

Cancer of the oral cavity, oropharynx, larynx, and hypopharynx

Thyroid disease and cancer

Salivary gland disease and cancer

Skin cancer and melanoma

Benign tumors of the head and neck

Microvascular reconstruction in the head and neck

Clinics

University of Minnesota Medical Center

Board Certifications

Otolaryngology

Research Summary

I have a long-standing interest in the functional recovery of sensory and motor functions after brain injury, such as stroke. I have been exploring technologies that can improve the functional recovery in stroke patients. Specifically, how is the somatosensory input processed in the primary somatosensory, primary motor, and premotor areas when the input is actively used in guiding behavioral tasks?

Recently, we found that the timing of hippocampal sharp-wave ripple events is modulated by the respiratory cycle. These findings represent a possible neuronal mechanism for a direct influence of the respiratory cycle on memory function. We also found that cerebellum modulates the intrinsic rhythmicity of eupneic breathing in a way that would be consistent with a cerebellar role in coordinating the respiratory rhythm with other orofacial movements, such as swallowing. Another line of my research also points to a possible role of the cerebellum as a coordinator of rhythms. We recently published causal evidence for a cerebellar role in controlling the coherence of neural oscillations between prefrontal cortex and hippocampal CA1 region during the decision-making process in a spatial working memory task. In ongoing research, we continue to investigate neuronal mechanisms of cerebro-cerebellar interaction, focusing on the modulation of functional connectivity between forebrain areas.

Bio

Joseph M. Metzger, Ph.D., is the Maurice Visscher Land-Grant Chair of Physiology and Professor and Head of Integrative Biology and Physiology at the University of Minnesota Medical School. The Metzger laboratory uses molecular and integrative biomedical approaches for mechanistic investigations of heart and skeletal muscle function, with the long-range goal of translating these findings to new therapies and treatments for acquired and inherited heart and muscle diseases.
Metzger Lab Mission Statement: We seek mechanistic insights into normal and diseased cardiac and skeletal muscle function. Our overarching goal is to translate basic science discoveries into potential therapeutic strategies to combat inherited and acquired forms of heart and muscle diseases. Lab projects embrace individuality, emphasize cooperation and collaboration, and encompass a standard of excellence to all that we do as individual researchers and as a laboratory. Our guiding principles are to treat others with respect and courtesy, to maintain the lab in a collegial, safe and professional environment, and to work each day to the fullest of our capabilities.
Metzger received a Bachelor's degree in Natural Science from Saint John's University, Collegeville, Minnesota (1980), a Master's degree in Biology and Exercise Physiology from Ball State University, Muncie, Indiana (1982), a Ph.D. degree in Biology/Physiology under the mentorship of Dr. Robert Fitts from Marquette University Milwaukee, Wisconsin (1985), and performed post doctoral studies with Dr. Richard Moss at the University of Wisconsin, Madison, Wisconsin (1991). His lab designed and implemented a cardiac muscle-cell system that allows the transfer of genes into heart cells in order to assess the impact of those genes on the production of force and motion, the major function of cardiac muscle cells. The approach has the advantage of shedding light on the primary role of a normal or mutated gene in an otherwise normal muscle cell.
Metzger's findings have been published in top peer journals including Nature, Science, Nature Medicine, the Journal of Clinical Investigation, and the Proceedings of the National Academy of Sciences. This research is funded by the National Institutes of Health (NIH), the American Heart Association, the Muscular Dystrophy Association, and the Federation to Eradicate Duchenne, and has opened the path to treatment for a variety of heart and muscle diseases.

Research Summary

We are a mechanistically driven biomedical research lab focused on the form and function of heart and skeletal muscle in health and disease. We use molecular and integrative biomedical approaches for mechanistic investigations of heart and skeletal muscle function, with the long-range goal of translating these findings to new therapies and treatments for acquired and inherited heart and muscle diseases.Integrative systems biology of cardiac and skeletal muscle function Gene therapy, Gene and Base Editing Synthetic chemistries as membrane stabilizers Transgenic models of heart and muscle diseases Molecular mechanisms of sarcomere function Human iPS cell cardiac and skeletal muscle

Bio

Dr. Miner is the Chief of Emergency Medicine at Hennepin County Medical Center, and is a Professor of Emergency Medicine at the University of Minnesota Medical School. He is board certified in Emergency Medicine and is the Senior Associate Editor for Electronic Publications of Academic Emergency Medicine. Dr. Miner conducts research in the areas of pain management, procedural sedation, altered mental status, shock, and monitoring during critical care in the Emergency Department and has numerous publications on these topics. He has edited a textbook on pain management and sedation (Emergency Pain and Sedation, Cambridge University Press, 2008) and has authored chapters about pain management, sedation, and monitoring in several other textbooks. He also conducts research in the effects of poverty on patients seen in the Emergency Department.

Bio

Dr. Leslie Morse obtained her Doctor of Osteopathic Medicine degree from the University of New England College of Osteopathic Medicine followed by her residency in Physical Medicine and Rehabilitation at Boston Medical Center. She is board certified by the American Board of Physical Medicine and Rehabilitation. Dr. Morse continues to work on local and national level to promote the field of rehabilitation medicine. 

Expertise

Therapeutic outcome analysis, stem cell therapy for spinal cord injury, osteoclast biology, gait training and analysis

Awards & Recognition

• 2020 American Paraplegia Society Excellence Award, Academy of Spinal Cord Injury Professionals (ASCIP)
• 2021 Rebecca “Becky” J. Adcock, PhD Award for Excellence in Mentoring, Academy of Spinal Cord Injury Professionals (ASCIP)

Professional Associations

• Member, Research Committee Member, Association of Academic Physiatrists
• International Society for Clinical Densitometry

Research Summary

Research Summary/Interests

Dr. Morse's research interests include the impact of mechanical unloading on bone metabolism and the development of novel stem cell therapies for motor recovery after SCI. 

Research Funding Grants

• Department of Defense
  SCI170159
  Role: Co-investigator
  2018 - 2022
  Assistive Technology and Functional Outcomes following Spinal Cord Injury (Monden PI) 
  The aims of this study are to: (1) examine perceived barriers to or facilitators of assistive technology (AT) access and utilization and the impact on functional and psychosocial outcomes after tetraplegia, (2) assess for variations in use of AT across insurance providers and socioeconomic status in Veterans and civilians with tetraplegia, (3) assess the relationship between AT use and productivity (employment/school), and (4) assess the relationship between AT and psychosocial outcomes.
• NIDILRR, Department of Health and Human Services
  90SI5015-01-00
  Role: Co-Project Director
  2016 - 2022
  Rocky Mountain Regional Spinal Injury System 
  The goals of this project are to (1) harness our existing multidisciplinary system of rehabilitation care designed specifically to meet the needs of individuals with SCI to extend the Model Systems knowledge base, (2) contribute to improving long term SCI outcomes through participation in site-specific and collaborative clinical trials and research projects, (3) contribute to the SCI model systems national database through longitudinal assessment of long term SCI outcomes, (4) Contribute to improved long term SCI outcomes by conducting a research project designed to reduce sublesional neuropathic pain following SCI.
• NIDILRR, Department of Health and Human Services
  H133A150065 (Nash PI)
  Role: Co-investigator
  2016 - 2021
  Lifestyle intervention targeting enhanced health and function for persons with chronic SCI in caregiver/care-receiver relationships: effects of caregiver co-treatment
  The goals of this project are to: 1) determine the efficacy of a lifestyle intervention to improve health and function of individuals with SCI.
• Department of Defense
  W81XWH-14-SCIRP-CTA
  Role: PI
  2015 - 2022
  Effects of Ekso-assisted gait training on Bone Health and Quality of Life: A Randomized Clinical Trial
  The goals of this project are to 1) determine whether exoskeleton-assisted gait training increases bone strength in the paralyzed lower extremity and 2) determine whether exoskeleton-assisted gait training improves quality of life after SCI. Secondarily, to determine whether gait training improves the following related outcomes and mediators of quality of life: mood, pain, and cortical activity of related emotional networks in the brain.
• NIH/NIAMS
  R01 AR064793-01A1 (Battaglino PI)
  Role: Co-investigator
  2015 - 2022
  Regulation of gastric and osteoclast acidification by Snx10
  The specific aims to be addressed in this project are: 1) Determine the cellular mechanisms by which Snx10 regulates osteoclast function. 2) Determine the role of osteoclastic expression of Snx10 on bone homeostasis in vivo. 3) Determine the whole of gastric expression of Snx10 on bone homeostasis in vivo.

Clinical Summary

Board Certifications

Physical Medicine and Rehabilitation (ABPMR)

Bio

As Department head, Dr. Nalin's responsibilities include oversight of the research, outreach and clinical teaching activities for faculty and students that align with the departmental goals towards enhancing the broader mission of the Medical School, Duluth Campus, focused on training the next generation of rural and American Indian physicians.Dr. Nalin was named the Co-Interim Regional Campus Dean of the University of Minnesota Medical School, Duluth Campus. He became active in this role on April 19, 2021.

Bio

Dr. Joseph Neglia is the Head of the Department of Pediatrics at the University of Minnesota Medical School and the Physician-in-Chief of the M Health Fairview Masonic Children's Hospital. He holds the Ruben-Bentson Chair and a joint appointment as Professor in the Department of Pediatrics and in the Division of Epidemiology and Community Health in the School of Public Health.

Dr. Neglia's area of research involves the long-term effects of cancer therapy in cancer survivors and the occurrence of second malignancies following childhood cancer. He is nationally and internationally recognized for his contributions to the field of childhood cancer long-term effects. He currently is Principal Investigator at the Masonic Cancer Center, University of Minnesota for the Children's Oncology Group (COG), and the vice-chair of the Voting Body of the COG. Dr. Neglia is also Principal Investigator of an American Cancer Society Grant investigating neuro-behavioral outcomes of children recently treated for leukemia.

Dr. Neglia has been involved in numerous service activities both within and outside of the University of Minnesota. He is an active member of Children's Oncology Group, American Society of Pediatric Hematology/Oncology, and Masonic Cancer Center at the University of Minnesota. He regularly reviews manuscripts for numerous journals including the New England Journal of Medicine, the Journal of the National Cancer Institute, and Cancer among others. At the University level, he has been elected as an alternate member of the University Senate and developed and directed the original Cancer Center Database.

Administrator Information

Administrative Phone: 612-624-3113
Administrative Email: pedchair@umn.edu

Bio

James Pacala, MD, MS, is professor and head of the University of Minnesota Department of Family Medicine and Community Health. Dr. Pacala has performed research and published extensively on models of care delivery to geriatric populations and innovative teaching methods. He is a past president of the American Geriatrics Society (AGS) and is co-author of the AGS practice handbook, Geriatrics At Your Fingertips. Pacala currently chairs the UCare Board of Directors. In 2013, he was appointed to the 2013-14 Health and Aging Policy Fellowship. He is also PI for the Minnesota Northstar Geriatrics Workforce Enhancement Program.

Clinical Summary

Geriatrics, medical student education, and health services research.

Bio

Dr. Regal was named the Co-Interim Regional Campus Dean of the University of Minnesota Medical School, Duluth Campus. She became active in this role on April 19, 2021 through Summer 2022.

Research Summary

The overall goals of my research program involve understanding basic immune mechanisms of cardiopulmonary disease. I have a long-standing interest in the complement system as a mediator of adverse events in disease states such as anaphylaxis, asthma and most currently pregnancy-induced hypertension. These interests have also involved defining mechanisms of pulmonary immunotoxicity of small molecule workplace allergens such as trimellitic anhydride. My research approach involves experimentation at the molecular, biochemical and physiological levels using animal models of disease. Current research projects include:

Pregnancy-induced Hypertension Preeclampsia and related hypertensive disorders of pregnancy affect ~10% of all pregnancies in the United States, significantly impacting the health of both mother and child. The initiating event of preeclampsia involves impaired blood flow to the placenta and the end result for the mother is high blood pressure and protein in the urine, along with growth restriction in the fetus. During pregnancy, the immune system including the plasma complement system, is tightly regulated to allow fetal survival. In women with preeclampsia the complement system is excessively activated, and our long-term goal is to determine the therapeutic utility of manipulating the complement system to prevent preeclampsia or minimize consequences for the mother and child. We hypothesized that complement system activation and white blood cell recruitment lead to hypertension in the mother and growth restriction in the fetus. Thus, we are manipulating the complement system and white blood cell function in a model of placental ischemia induced high blood pressure to determine the critical mechanisms responsible for the pregnancy complications. Our most recent studies are defining the role of natural antibody and the B lymphocyte in initiating complement activation in vivo, and assessing the importance of endogenous complement regulators in limiting the activation.

Dr. Regal's lab is currently funded through the National Heart Lung and Blood Institute of NIH and the American heart Association. 
 

Professional Associations

• Director, AHC Women's Mentoring Program
• Director, AHC Duluth Research Seminar Series
• Editorial Board, Hypertension
• Editorial Board, Toxicological Sciences
• Associate Editor, Journal of Immunotoxicology
• Fellow, Academy of Toxicological Sciences

Teaching Summary

Chemotherapy of Infection; Anti-inflammatory Drugs; Drugs for Pulmonary Disorders
Mentoring/Advising: undergraduates, graduate & post-doctoral fellows
 

Bio

Administrator Info
Name: Sarah Chapeau
Phone: 612-625-3654
Email: chape044@umn.edu
Fax: 612-626-3107
Mail: 420 Delaware Street SE, MMC 194, Minneapolis, MN 55455

Summary
Dr. Elizabeth Seaquist is the Nesbitt Chair and Head of the Department of Medicine. Awards recognizing her research and mentoring include the American Diabetes Association’s Transformative Woman in Diabetes Award in 2019 and the Albert Renold Award for Mentoring in 2020. She served as the President for Medicine and Science of the American Diabetes Association in 2014. As a clinical investigator, Dr. Seaquist is interested in hypoglycemia and the complications of diabetes. Her research focuses on the effect of diabetes on brain metabolism, structure, and function. She was the site investigator for the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial, the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE) study, and the Researching Cardiovascular Events with a Weekly Incretin in Diabetes (REWIND) study. She has an active clinical practice and is board certified in Internal Medicine and Endocrinology, Diabetes, and Metabolism.

Research Summary

• Impact of diabetes on cerebral structure and function
• Hypoglycemia in diabetes

Clinical Trials

• Cerebral Responses to Insulin-Induced Hypoglycemia
• Effect of Recurrent Hypoglycemia

Clinical Summary

• Management of type 1 and type 2 diabetes
• Complications of diabetes
• Hypoglycemia in diabetes

Bio

Dr. Terezakis focuses her clinical practice on pediatric cancers, hematologic malignancies including lymphoma, as well as musculoskeletal tumors. Her clinical and translational research incorporates advanced diagnostic radiology techniques into the radiation treatment planning of cancers to minimize long-term side effects and improve efficacy of treatment. She is also an active investigator of stereotactic body radiation therapy techniques in pediatric and adult tumors. Dr. Terezakis is a leader within the Children's Oncology Group (COG) that develops and runs national clinical trials for children with cancer as well as multiple national committees that establish the standard of care for cancer treatment.

Clinical Summary

Pediatric cancers; Hematologic malignancies; Bone and soft tissue sarcomas; Stereotactic body radiotherapy

Bio

Dr. van Kuijk is particularly interested in treating patients with Age-Related Macular Degeneration (AMD), he has a long track record of research into pathogenesis of AMD. In addition, he sees patients with diabetic retinopathy and inherited retinal degenerations.

Research Summary

Dr. van Kuijk's clinical and research interests are laser tissue interaction, the molecular basis of and the role of genetics on efficiency of nutritional intervention in Age-Related Macular Degeneration (AMD), and the use of investigational drugs in AMD and diabetic retinopathy.

Clinical Summary

Dr. van Kuijk is particularly interested in treating patients with Age-Related Macular Degeneration (AMD), he has a long track record of research into pathogenesis of AMD. In addition, he sees patients with diabetic retinopathy and inherited retinal degenerations.

Bio

I am the Department Head of Psychiatry & Behavioral Sciences at the University of Minnesota Medical School and the Donald W. Hastings Endowed Chair in Psychiatry. I was previously the Vice-Chair of the Department of Psychiatry at the University of California, San Francisco, and the Associate Chief of Staff for Mental Health at the San Francisco VA Medical Center. I received my M.D. from Wayne State University School of Medicine, obtained my psychiatry residency training at Stanford University School of Medicine, where I served as Chief Resident, and completed a Psychiatric Neurosciences Research Fellowship at the Palo Alto VA Medical Center and Stanford University.I direct a translational clinical neuroscience laboratory that focuses on cognitive dysfunction in psychotic disorders. I study the neuroplastic effects of cognitive training on the brain with the goal of understanding how to change brain system functioning and promote recovery. Our work focuses on young adults in early phases of psychosis, with the goal of providing intensive early interventions to ensure optimal outcomes. We have strong research collaborations with colleagues in the basic neurosciences and I co-facilitate a multi-disciplinary workgroup called Nuroplasticity Research in Support of Mental Health (NeuroPRSMH).My work has contributed to a growing interest in the use of computerized "brain training" to treat brain information processing abnormalities. I was a participant at the past White House conference on "Video Games to Enhance Attention and Well-Being." Professional and public service have also been a key focus of my career. I am a member of the Senior Women's Leadership Group at the Society of Biological Psychiatry and Deputy Editor of Schizophrenia Research Journal . Within my department, I lead the Clinical Neuroscience curriculum for the residency program.

Bio

Dr. Jerry Vitek is the Head of the Neurology Department, Director of the Neuromodulation Research Program, and Center Director of the University of Minnesota Udall Center of Excellence for Parkinson's Research. He previously served as the Neuromodulation Research Center Director at the Lerner Research Institute of the Cleveland Clinic Foundation developing functional surgery and deep brain stimulation (DBS) techniques for the treatment of neurological disease. Dr. Vitek has also held faculty positions at Emory University and The Johns Hopkins University, where he assisted in the development of the functional neurosurgery programs and conducted research on the pathophysiology of movement disorders and mechanism(s) underlying the beneficial effects of DBS.He is currently the PI on several NIH-, foundation- and industry-funded grants, which include both non-human primate and human clinical studies on the neurophysiology of movement disorders and neuromodulation mechanisms. Dr. Vitek is also the PI for an industry-sponsored multicenter phase III pivotal clinical trial to investigate the safety and efficacy of a new neuromodulation device for the purposes of an FDA PMA submission. Many of his research projects involve close collaboration with other neurologists, neuroscientists, neurosurgeons, radiologists, and/or biomedical engineers. Much of this work has provided new insight into the neurophysiology of movement disorders and the therapeutic mechanisms of DBS and contributed to improvements in DBS surgery and treatment as well as the application of DBS to other neurological disorders.

Research Summary

Dr. Vitek directs a large interdisciplinary neuromodulation research program primarily centered on understanding the pathophysiology of movement disorders such as Parkinson's disease and dystonia as well as the mechanisms underlying the therapeutic effect of deep brain stimulation. Dr. Vitek serves as the principal investigator for both pre-clinical laboratory studies using animal models and clinical studies on human subjects/patients. Much of his work focuses on the ultimate translation of basic laboratory research discoveries into clinical treatment options for affected patients in order to reduce symptoms, minimize side effects and enhance function and quality of life. Dr. Vitek forms key collaborations with other experts in neurology as well as other disciplines such as neurosurgery, neuroscience, biomedical science, and radiology in addition to the medical industry to expedite and enhance new discoveries and their meaningful translation from "bench to bedside".

Clinical Summary

Parkinson's Disease; Dystonia; Tremor; Movement Disorders; DaTscan Imaging; Deep Brain Stimulation

Bio

Michael Wall, MD, FASA, FCCM, is the JJ Buckley Professor and Chair of the Department of Anesthesiology at the University of Minnesota Medical School. He also serves as Senior Vice President and physician leader for the M Health Fairview University of Minnesota Medical Center.

Dr. Wall received his medical degree from Dartmouth. He completed residency at the University of Washington in general surgery and anesthesiology, in which he served as chief resident. He has also completed fellowships in cardiothoracic anesthesiology and critical care medicine. In addition to his university appointments, Dr. Wall also serves on the board of directors for the Metro Minnesota Council on Graduate Medical Education, the Minnesota Society of Anesthesiologists, and the Society of Critical Care Anesthesiologists.

Bio

Dr. Christopher Warlick is the Department Head for the Department of Urology and is an Associate Professor who treats several urologic cancers, with an emphasis on prostate cancer. Dr. Warlick has a busy prostate cancer practice and is a nationally recognized leader on Active Surveillance for low risk prostate cancer, while performing robotic-assisted laparoscopic radical prostatectomies for men requiring definitive therapy. Dr. Warlick has ongoing research focusing on the use of MR imaging in prostate cancer, the development of novel tests to help determine early signs of disease progression, and on programs to increase the use of shared decision making around PSA screening and prostate cancer treatment decision making.

Bio

Dr. Wickman is a Frederick and Alice Stark Endowed Chair, a Full Professor and Head of the Department of Pharmacology. He received his BA in Chemistry (summa cum laude) from Saint Olaf College in Northfield, MN. Subsequently, he earned his PhD in Molecular Neuroscience (advisor: Dr. David Clapham) from the Mayo Foundation for Biomedical Research in Rochester, MN. Following postdoctoral training at Mayo Clinic Scottsdale (advisor: Dr. Sandra Gendler) and Children's Hospital/Harvard Medical School in Boston, MA (advisor: Dr. David Clapham), he accepted a tenure-track faculty position (Assistant Professor) in Pharmacology at the University of Minnesota in 1999. He was promoted to Associate Professor in 2005, and Professor in 2011. He currently holds the titles of Distinguished University Teaching Professor and Distinguished McKnight University Professor.

Research Summary

Research in the Wickman lab centers on mechanisms controlling the excitability of cells in the heart and brain. Dysregulation of cell excitability contributes to many debilitating and/or life-threatening medical conditions, including cardiac arrhythmias, epilepsy, anxiety, depression, schizophrenia, Down Syndrome, addiction, and pain. The Wickman lab seeks to obtain detailed understanding of molecular mechanisms that regulate cell excitability, so that safer and more effective strategies to treat these medical problems can be envisioned and developed. Investigators in the Wickman lab are currently using approaches in electrophysiology, neuromodulation, genetic manipulation, intracranial pharmacology, cardiac physiology, and behavioral assessments relevant to addiction, anxiety, learning, and pain to understand the physiological and pathophysiological relevance of inhibitory signaling pathways.