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Alexander Herman is an Assistant Professor of Psychiatry at the University of Minnesota Medical School and member of the Medical Discovery Team on Addiction. Dr. Herman's human neuroscience lab studies neural mechanisms of decision making that are impaired in addiction and amenable to treatment with neuromodulation. His lab combines invasive and non-invasive methods including intracranial electrophysiology, direct brain stimulation, magnetoencephalography and transcranial magnetic stimulation.
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Dr. Zilverstand is an assistant professor in the Department of Psychiatry and member of the University of Minnesota's Medical Discovery Team on Addiction. Her work is focused on investigating how individual differences contribute to human drug addiction. Her research group combines the analysis of existing large-scale multimodal data sets with the acquisition of new data through a variety of techniques such as interviewing, neurocognitive testing, questionnaires and multi-modal neuroimaging. Novel computational methods are employed for linking social, demographic, neurocognitive, personality and clinical measures to the neuroimaging data, to explore the existence of neurobiological subtypes within the addicted population. The goal of this research is to develop neuroscience-derived individualized treatment for individuals who are at risk for either escalation of drug use or relapse.
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Dr. Jan Zimmermann is an Assistant Professor in the Department of Neuroscience and the Center for Magnetic Resonance Research. His lab studies how the brain represents and constructs subjective value and how that signal is used to guide decision making. The lab is particularly interested in how the brain adaptively changes its coding strategy to encode statistical regularities within a changing environment. Using electrophysiology, ultra high field MRI and computational modeling the lab tries to understand how changes in reward encoding sensitivity could relate to a propensity for drug addiction.
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Marco Pravetoni is an associate professor of Medicine at the University of Minnesota Medical School. His research interest focuses on novel and more effective treatments for substance use disorders. Dr. Pravetoni’s has developed vaccines for the treatment of heroin and prescription opioid abuse and overdose. His group is also implementing a variety of strategies to generate more effective vaccines or antibody-based therapies against drugs of abuse and other unmet medical needs such as antibiotic-resistant bacteria.
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Dr. Widge is a psychiatrist and biomedical engineer. Clinically, he provides brain stimulation treatments for mood, anxiety, and substance disorders. These include deep brain stimulation, cortical stimulation, and transcranial magnetic stimulation. His research focuses on developing these treatments further, particularly the creation of new "closed loop" devices. These devices sense brain signals in real-time and deliver energy in a planned and rational fashion, compensating for each patient's specific brain network abnormalities. Dr. Widge's laboratory prototypes new stimulation paradigms and targets in rodent models, conducts clinical trials of these new technologies, and searches for biomarkers of illness and recovery to guide next-generation therapies.
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Jocelyn Richard is an Assistant Professor in the Department of Neuroscience, investigating how external cues interact with stress and negative emotional states to drive drug and alcohol seeking, even after long periods of abstinence. By measuring the activity of neurons critical for normal reward seeking, Dr. Richard can predict how intensely rats will seek out rewards like alcohol when they are exposed to environmental cues that have been previously associated with these rewards. She aims to determine what causes these neurons to be more active when animals are especially vulnerable to relapse, such as during times of intense stress or anxiety.
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Benjamin Saunders is an assistant professor of neuroscience and member of the UMN Center for Addiction Neuroscience and Medical Discovery Team on Addiction. His research explores how drug-associated cues in the environment engage the brain to trigger drug use and relapse, with the goal of identifying biological pathways that can be targeted to prevent these behaviors.
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Steven Graves is an Assistant Professor in the Department of Pharmacology. His research is focused on the neurotoxic effects of particular psychostimulants like methamphetamine and their associations with neurodegenerative diseases.
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Sade Spencer is an assistant professor of Pharmacology and a new MDT faculty hire. The broad goal of her research is to understand the synaptic mechanisms and neurocircuitry underlying drug addiction and comorbid neuropsychiatric diseases. More specifically, her research examines specific changes in synaptic transmission during and after drug self-administration. To accomplish this goal, her lab studies neuroadaptations and behavior in rodent models of addiction using standard approaches in protein biochemistry and behavioral pharmacology as well as incorporating novel techniques to genetically isolate specific cell types and circuits implicated in addiction.
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Julia Lemos is an Assistant Professor of Neuroscience and member of the University’s Medical Discovery Team on Addiction. Her laboratory investigates how stress is processed and encoded in the brain. In particular, they interested in understanding how stress-associated neuropeptides regulate the function of neural circuits important for motivation and emotion in individuals with different life histories. Her laboratory also works to understand how chronic or traumatic stress renders the brain vulnerable to disease states such as depression, anxiety, and addiction.
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Ben Hayden is an associate professor in the Department of Neuroscience and the Center for Magnetic Resonance Research. His lab studies the role of the brain activity in making reward-based decisions, and in changing strategies in demanding circumstances. They do this with recordings of activity of populations of neurons in subjects making and adjusting simple decisions. They then compare these patterns with those obtained from subjects exposed to cocaine for long periods of times. This research contributes to a basic understanding of the brain circuitry of drug addiction.
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Sarah Heilbronner is an assistant professor in the Department of Neuroscience. She studies the "wiring diagram" of the brain. She and her team are trying to determine how different brain regions connect with one another. She is especially interested in circuits responsible for abnormal motivation and decision-making in addiction. Heilbronner uses these connectivity studies to figure out how to translate results from humans to nonhuman animal model species, and vice versa.
Dr. Anker received his PhD in Cognitive and Biological Psychology from the University of Minnesota. As a graduate student and postdoctoral trainee, Dr. Anker’s work focused on the biological and behavioral factors that influence vulnerability to addiction and treatment response. Dr. Anker’s current work focuses on translational research that combines methods of assessing biological stress with clinical addiction treatment methods.
Alfonso Araque is a professor in the Department of Neuroscience. His research interests focus on the mechanisms, properties and physiological consequences of the communication between neurons and astrocytes. His research seeks to understand how the communication between neurons and astrocytes affects physiological and pathological aspects of brain function. While most studies on drug addiction are focused on neuronal mechanisms, his team aims to elucidate the involvement of astrocytes in behaviors associated with reward signaling and psychostimulant drugs, which may reveal astrocytes as potential targets for treatment of motivation disorders such as drug addiction.
Dr. Bart is an associate professor of Medicine at the University of Minnesota and director of the division of Addiction Medicine at Hennepin Healthcare. He is an internist and addiction medicine specialist. His areas of expertise include clinical pharmacology and the pharmacological management of opioid use disorders. His current research areas include the population pharmacokinetics of methadone, genetic influences of methadone pharmacology and treatment outcome, and improving strategies to integrate treatment of opioid use disorders into general medical settings. Dr. Bart is co-PI of NorthStar Node of the NIDA National Drug Abuse Treatment Clinical Trials Network and he is co-Director of the PEPFAR-SAMHSA funded Vietnam HIV-Addiction Technology Transfer Center.
Dr. Camchong investigates the neurobiological basis of addiction. Using neuroimaging techniques such as fMRI, she studies the relationship between patterns of brain circuit activity and treatment outcome, and the ability of non-invasive brain stimulation methods to strengthen brain circuits that support abstinence. Her goal is to develop effective non-drug, non-invasive brain stimulation interventions that aid recovery from addiction and complement existing treatment programs.
Marilyn Carroll is a Professor in the Department of Psychiatry and Behavioral Science. Her research is focused on factors that underlie drug and food addiction, such as genetic differences, impulsivity, and hormonal influences. As Director of a recent P50 Center grant, she conducts translational research with animal and human subjects on sex differences, stimulant addiction and novel treatments. Currently, she is developing animal models of novel self-initiated and -maintained long-term treatments for addiction with the translational goal of having addicted drug users manage their treatment and recovery over long periods of time.
Wei Chen is a Professor of the Departments of Radiology. His research at the Center for Magnetic Resonance Research (CMRR) focuses on development of magnetic resonance imaging (MRI)/spectroscopy (MRS) methodologies and technologies for non-invasively studying cellular metabolism, bioenergetics, function and dysfunction of the brain and other organs, which could be valuable for addiction research.
Brenna Greenfield is a licensed clinical psychologist and assistant professor in the Department of Family Medicine and Biobehavioral Health on the Duluth Campus of the University of Minnesota Medical School. Her research focuses on substance use disorder treatment and recovery, with an emphasis on behavioral treatments such as mindfulness-based relapse prevention and motivational interviewing, mechanisms of behavior change, longitudinal health services research, and the promotion of health equity. She primarily collaborates with American Indian tribal nations.
Andrew Harris is a senior investigator at the Hennepin Healthcare Research Institute and an associate professor in Medicine and Psychology at the University of Minnesota. His research involves the use of preclinical models to study the behavioral pharmacology of addiction to nicotine, opioids, and other drugs of abuse.
Dorothy K. Hatsukami is a Professor in the Department of Psychiatry and is the Associate Director for the Masonic Cancer Center. Her research is focused on understanding tobacco addiction, testing novel tobacco cessation treatments and exploring ways to make currently marketed tobacco products less toxic, appealing and addictive.
Suhasa Kodandaramaiah is an Assistant Professor in the Department of Mechanical Engineering at the University of Minnesota. His laboratory focuses on engineering neurotechnologies to interface with the brain at multiple spatial and temporal scales. These include robotic tools for single cell recording and manipulation and #d printed polymer implants for large scale neural activity readout and perturbation.
Michael Kotlyar is an associate professor in the Department of Experimental and Clinical Pharmacology at the University of Minnesota College of Pharmacy. His research focuses on evaluating various aspects of tobacco dependence including assessing medications to assist in the smoking cessation attempt and assessing the role of stress on smoking behavior.
Esther Krook-Magnuson is an Assistant Professor in the Department of Neuroscience. Her work focuses on brain circuitry, including the different types of neurons in the brain and their responsiveness to drugs like opioids.
Anna Lee is an Assistant Professor in the Department of Pharmacology. Her research focuses on the mechanisms of alcohol and nicotine co-addiction, and the role of nicotinic acetylcholine receptors in mediating alcohol and nicotine addiction. Recent interests also include the abuse liability of electronic cigarettes, and sex differences in nicotinic receptor function.
Mark LeSage is a Senior Investigator in the Department of Medicine at the Hennepin Healthcare Research Institute, and Professor in the Department of Medicine and Adjunct Associate Professor in Psychology at the University of Minnesota. His research is primarily focused on the behavioral pharmacology of nicotine and tobacco, with a focus on using nonhuman drug self-administration and other models to address issues related to tobacco harm reduction and FDA regulation of tobacco products. He also employs nonhuman models to study the behavioral pharmacology of other drugs of abuse (cocaine, opioids) and develop immunotherapies (e.g. vaccines, antibodies) and other types of pharmacotherapies to treat drug abuse.
The misuse of and addiction to prescribed and illegally obtained opioids has caused a national crisis that affects public health and welfare. Our research is focused upon the structural and functional deficits in dendritic spines caused by neurological diseases and disorders. We found that opioids caused collapse of dendritic spines, which are the fundamental structural units for information storage and processing in the brain. The opioid-induced changes in dendritic spines may contribute to opioid addictions as well as opioid-induced cognitive deficits.
Dr. Lim is Professor and Vice Chair for Research in the Department of Psychiatry where he holds the Drs. T.J. and Ella M. Arneson Land Grant Chair in Human Behavior. Dr. Lim’s research interest is in the use of neuroimaging approaches to identify circuit abnormalities in brain disorders such as schizophrenia, traumatic brain injury and addiction and then to use these circuits as treatment targets for noninvasive neuromodulation interventions.
Robert Meisel is a professor in the Department of Neuroscience. A key question addressed by his lab is what makes some people more vulnerable than others to the addictive effects of drugs? One idea he has been testing in an animal model of addiction vulnerability is that the converging neural plasticity of behavioral experience and drug use renders the brain more susceptible to the addictive properties of drugs.
Paul Mermelstein is a professor in the Department of Neuroscience. His laboratory researches sex differences in the brain. Specifically, how sex hormones (estrogen in females, testosterone in males) alter the synaptic connections in the brain to influence motivated behaviors. He and his team have discovered that when estrogen concentrations rise in females, their vulnerability to abuse addictive drugs increases. They are seeking to determine the mechanisms by which estrogens impart vulnerability to drug addiction, and ways to circumvent these changes in brain plasticity, ultimately in hopes of improving therapeutic interventions.
Jessica Nielson is a neurobiologist and data scientist working at the intersection of computer science and psychiatry to understand the neurobiological mechanisms of mental health disorders that underlie addictive behaviors. She brings her expertise in neuroscience, big-data and precision medicine techniques to the group for data-driven discovery of clinically relevant models of addictive behaviors, with an interest in researching and developing novel therapies to treat the root causes of addiction.
Laura Palombi is an assistant professor at the College of Pharmacy in Duluth. She works with rural community members and coalitions to find community-specific solutions to the opioid crisis and to capitalize on community recovery capital. She also works closely with public health, health professions, and harm reduction professionals to increase access to naloxone.
Dr. Pham is a physician and assistant professor in the Department of Medicine and Pediatrics at the University of Minnesota Medical School. He works clinically as a hospitalist at the University of Minnesota Medical Center and as a primary care physician at the Community University Health Care Center (CUHCC). His work on academic medical education in health equity as well as with the underserved communities in the Twin Cities has led him to focus on Community-Based Participatory Research. His current research is in collaboration with the local urban American Indian community to develop a culturally-centered and family-centered approach to opioid use disorder treatment in primary care settings.
The Portoghese Research Group is focused on the design and synthesis of compounds that target opioid receptors, both as pharmacologic tools and as agents for treatment of pain. Novel concepts and approaches are employed for development of analgesics that are highly selective for different types of opioid receptors.
David Redish is a Distinguished McKnight University Professor in the Department of Neuroscience. He and his team explore the computational processes that underlie decision-making. His research addresses questions of addiction from the perspective of addiction as dysfunctions in those decision-making processes. His research interests span the neurophysiology of behavior, including computational, experimental, theoretical, and clinical approaches. His laboratory has major research efforts in theoretical explanations of the interactions of multiple decision-making systems, in the neurophysiology of the information processing in those decision-making systems, and in the clinical consequences of dysfunction in those decision-making systems. Through collaborations with other neuroscientists and psychologists translating their novel decision tasks to human populations, and clinicians testing consequences of their proposed explanations for dysfunction, Dr. Redish and his team explore the similarities and differences across species as a means of understanding addiction and its treatment.
Patrick Rothwell is an Assistant Professor in the Department of Neuroscience. His research lab investigates the synaptic organization and behavioral function of basal ganglia circuits in health and disease. His interests include regulation of these circuits by endogenous opioid signaling, as well as the detrimental effects of chronic exposure to exogenous opioids, with a broad goal of reducing the abuse liability of opioid-based clinical therapies.
Linda Skalski is a licensed clinical psychologist who specializes in assessment and treatment for individuals with substance use disorders. Dr. Skalski's research focuses on understanding how cannabis use impacts relapse to alcohol among patients with an alcohol use disorder. She also examines how cannabis use impacts treatment outcomes for mood, anxiety, and other drug use disorders.
Dr. Thayer is a professor of Pharmacology. His laboratory studies endocannabinoid signaling. Cannabinoids, analogs of the psychoactive ingredient in marijuana, act on receptors that are part of this system. Current studies examine the role of the endocannabinoid system in regulating synaptic transmission, neuroinflammation, and neurotoxicity.
Phu Tran is an Assistant Professor in the Department of Pediatrics. His research focuses on the role of epigenetics in long-term effects of early-life adversity on neural development. His lab has been investigating whether opioids exposure during pregnancy alters the epigenetic signatures of the infant’s cord blood stem cells and whether such change can be a determining factor for addictive behaviors in adolescence and adulthood.
Research Associate Professor
Michael A. Walters is a Research Associate Professor in the Department of Medicinal Chemistry. He is also a director in the Institute for Therapeutics Discovery and Development (ITDD), a full-service drug discovery and development unit within the College of Pharmacy. His research focuses on the synthesis and characterization of novel compounds for the treatment of pain without the abuse liabilities associated with opioids. He is currently collaborating on the development of a compound called MMG22 (Portoghese Laboratory) which shows promise for the non-addictive treatment of cancer pain.
Professor and Vice Head
Kevin Wickman is a professor and Vice Head in the Department of Pharmacology. His research program seeks to elucidate inhibitory signaling pathways that regulate the excitability of neurons in the reward circuitry. His team's recent efforts have shown that inhibitory G protein-dependent signaling pathways in the ventral tegmental area and prefrontal cortex normally serve to limit addiction-related behaviors evoked by administration of opioids and psychostimulants, but that the influence of these pathways is diminished with repeated drug exposure. They employ intracranial viral genetic and pharmacologic approaches, together with electrophysiological and behavioral analyses, to understand the molecular and cellular mechanisms underlying the reciprocal relationship between inhibitory signaling pathways in the reward circuitry and drugs of abuse. The premise behind their efforts is that if endogenous inhibitory signaling pathways can be strengthened to prevent their suppression by drugs of abuse, then the risk of addiction in susceptible individuals and/or relapse in recovering addicts might be reduced or prevented.