Daniel Garry, MD, PhD
Professor of Medicine, Lillehei Heart Institute

Contact Info
Professor of Medicine, Lillehei Heart Institute
Preceptor, Medical Scientist Training Program (Combined MD/PhD Training Program)
Faculty, PhD Program in Integrative Biology and Physiology
Faculty, PhD Program in Molecular, Cellular, Developmental Biology and Genetics
Faculty, Masters Program in Stem Cell Biology
Cardiologist
Medical School, University of Minnesota, Minneapolis, MN
Residency, University of Minnesota, Minneapolis, MN
Fellowship, UT Southwestern Medical Center, Dallas, TX
Summary
Awards & Recognition
Professional Associations
Research
Research Summary/Interests
Regenerative medicine, Cardiogenesis, and Stem-Cell Biology
Dan’s laboratory has a long-standing interest in regenerative and stem cell biology with a focus on the heart and skeletal muscle. In their studies of the heart and skeletal muscle, the Garry laboratory utilizes an array of technologies including gene disruption strategies, transgenesis, single cell genome analysis, gene editing (TALEN and CRISPR technologies), inducible ES/EB model systems, hiPSC technologies, FACS and other cellular, biochemical and molecular biological techniques. In addition, their use of lower organisms such as zebrafish and newt, which are highly regenerative model systems have successfully uncovered critical regenerative factors. Human iPSCs are another important model for cardiovascular disease investigation for the lab. Using these technologies, the Garry lab was among the first to discover the molecular markers of stem cell populations that regulate critical networks during heart and skeletal muscle development and regeneration. For example, their studies have uncovered novel Ets and Forkhead transcription factors, microRNAs and signaling pathways that direct fate determination of stem cell populations. The manipulation of these pathways using chemical genetics and molecular technologies has provided a platform focused on rebuilding and repairing the injured heart and skeletal muscle.
Care Philosophy
My philosophy is to provide outstanding comprehensive care to patients with cardiovascular disease, including a number of emerging technologies available at the University of Minnesota Medical Center-Fairview. My practice combines state-of-the-art therapies, compassion, and effective communication, creating a working partnership that results (overall) in high quality of life for my patients.
Publications
A complete list of publications can be found here: Experts@Minnesota / Daniel J. Garry
- Shi X., Richard J., Zirbes K., Gong W., Lin G., Kyba M., Thomson J.A., Koyano-Nakagawa N., Garry D.J. (2014) Cooperative interaction of Etv2 and Gata2 regulates the development of endothelial and hematopoietic lineages. Developmental Biol., 389:208-218.
- Chann, SS, Shi X, Toyama A, Arpke RW, Dandapat A, Iacovino M, Kang J, Le G, Hagen HR, Garry D.J., Kyba M. (2013) Mesp1 patterns mesoderm into cardiac, hematopoietic, or skeletal myogenic progenitors in a context-dependent manner. Cell Stem Cell, 12:587-601.
- Koyano-Nakagawa N., Kewon J., Iacovino M., Shi X., Rasmussen T.L., Borges L., Zirbes K.M., Li T., Perlingeiro R.C.R., Kyba M., Garry D.J. (2012). Etv2 is expressed in the yolk sac hematopoietic and endothelial progenitors and regulates Lmo2 gene expression. Stem Cells. 30:1611-1623.
- Rasmussen T., Kweon J., Diekman M.A., Belema-Bedada F., Song Q., Bowlin K., Shi X., Ferdous A., Li T., Kyba M., Metzger J.M., Koyano-Nakagawa N., Garry D.J. (2011) ER71 directs mesodermal fate decisions during embryogenesis. Development, 138:4801-4812.
- Caprioli A., Koyano-Nakagawa N., Iacovino M., Shi X., Ferdous A., Harvey R.P., Olson E.N., Kyba M., Garry D.J. (2011). Nkx2-5 represses Gata1 gene expression and modulates the cellular fate of cardiac progenitors during embryogenesis. Circulation. 123:1633-1641.
- Ferdous A., Caprioli A., Iacovino M., Martin C.M., Morris J., Richardson J.A., Latif S., Hammer R.E., Harvey R.P., Olson E.N., Kyba M., Garry, D.J. (2009). Nkx2-5 transactivates the Ets-related protein 71 gene and specifies an endothelial/endocardial fate in the developing embryo. Proc. Natl. Acad. Sci. USA 106:814-819.
- Garry D.J., Olson E.N. (2006). A common progenitor at the heart of development. Cell. 127(6):1101-4.
- Garry D.J., Ordway G.A., Lorenz J.N., Radford N.B., Chin E.R., Grange R.W., Bassel-Duby R., and Williams R.S. (1998) Mice without myoglobin. Nature, 395:905-908.
Clinical
Specialties
- Cardiology
Clinics
Transplant Center
Clinical Interests
General cardiology; Advanced heart failure; Orthotopic heart transplant
Hospital Privileges
Heart -- University of Minnesota Physicians Heart at Fairview; UMPhysicians Heart at University of Minnesota Medical Center, Fairview; Transplant Center