Daniel Garry

Professor of Medicine
Preceptor, Medical Scientist Training Program (Combined MD/PhD Training Program)
Faculty, PhD Program in Integrative Biology and Physiology
Faculty, PhD Program in Molecular, Cellular, Developmental Biology and Genetics
Faculty, Masters Program in Stem Cell Biology


Administrator Info
Name: Lisa Moe
Email: seif0046@umn.edu
Mail: Lillehei Heart Institute
2231 6th Street SE
1st floor Mailroom CCRB
Minneapolis, Minnesota 55455

Research Summary

Regenerative medicine, Cardiogenesis, and Stem-Cell BiologyDan's laboratory has a long-standing interest in regenerative and stem cell biology with a focus on the heart and skeletal muscle. In their studies of the heart and skeletal muscle, the Garry laboratory utilizes an array of technologies including gene disruption strategies, transgenesis, single cell genome analysis, gene editing (TALEN and CRISPR technologies), inducible ES/EB model systems, hiPSC technologies, FACS and other cellular, biochemical and molecular biological techniques. In addition, their use of lower organisms such as zebrafish and newt, which are highly regenerative model systems have successfully uncovered critical regenerative factors. Human iPSCs are another important model for cardiovascular disease investigation for the lab. Using these technologies, the Garry lab was among the first to discover the molecular markers of stem cell populations that regulate critical networks during heart and skeletal muscle development and regeneration. For example, their studies have uncovered novel Ets and Forkhead transcription factors, microRNAs and signaling pathways that direct fate determination of stem cell populations. The manipulation of these pathways using chemical genetics and molecular technologies has provided a platform focused on rebuilding and repairing the injured heart and skeletal muscle. Care Philosophy My philosophy is to provide outstanding comprehensive care to patients with cardiovascular disease, including a number of emerging technologies available at the University of Minnesota Medical Center-Fairview. My practice combines state-of-the-art therapies, compassion, and effective communication, creating a working partnership that results (overall) in high quality of life for my patients.

Clinical Summary

General cardiology; Advanced heart failure; Orthotopic heart transplant


BS, Cum laude, St. John’s University
Major: Natural Sciences
MD, University of Minnesota

Honors and Recognition

Winner, American Heart Association
Winner, Astra-Merck Young Investigator Basic Science Research Award
Howard Hughes Institutional Scholar Award
Finalist, AHA Council on Circulation Cardiovascular Research Prize
Finalist, ACC Young Investigator’s Award
Basil O’Connor Starter Scholar Research Award, March of Dimes Association
AstraZeneca Young Investigator Award
Doris Duke Innovation in Clinical Research Award
Finalist, ACC Young Investigator’s Award
AHA Established Investigator Award
Recipient, Gail Griffiths Hill Endowed Chair in Cardiology, UT Southwestern Medical Center
Abbott Endowed Chair in Cardiovascular Sciences, University of Minnesota
Distinguished Alumni Award, St. John’s University
Best Doctor, Minnesota Monthly

Professional Memberships

NHLBI R01 grants, Established Investigator Award of the AHA, PI
NHLBI Progenitor Cell Biology Consortium , Steering Committee Member
Midwestern Progenitor Cell Biology Consortium , PI
American Heart Association , Fellow
Selected Publications

Selected Publications

Caprioli A., Koyano-Nakagawa N., Iacovino M., Shi X., Ferdous A., Harvey R.P., Olson E.N., Kyba M., Garry D.J. (2011). Nkx2-5 represses Gata1 gene expression and modulates the cellular fate of cardiac progenitors during embryogenesis. Circulation. 123:1633-1641.,
Rasmussen T., Kweon J., Diekman M.A., Belema-Bedada F., Song Q., Bowlin K., Shi X., Ferdous A., Li T., Kyba M., Metzger J.M., Koyano-Nakagawa N., Garry D.J. (2011) ER71 directs mesodermal fate decisions during embryogenesis. Development, 138:4801-4812.,
Chann, SS, Shi X, Toyama A, Arpke RW, Dandapat A, Iacovino M, Kang J, Le G, Hagen HR, Garry D.J., Kyba M. (2013) Mesp1 patterns mesoderm into cardiac, hematopoietic, or skeletal myogenic progenitors in a context-dependent manner. Cell Stem Cell, 12:587-601.,
Koyano-Nakagawa N., Kewon J., Iacovino M., Shi X., Rasmussen T.L., Borges L., Zirbes K.M., Li T., Perlingeiro R.C.R., Kyba M., Garry D.J. (2012). Etv2 is expressed in the yolk sac hematopoietic and endothelial progenitors and regulates Lmo2 gene expression. Stem Cells. 30:1611-1623.,
Shi X., Richard J., Zirbes K., Gong W., Lin G., Kyba M., Thomson J.A., Koyano-Nakagawa N., Garry D.J. (2014) Cooperative interaction of Etv2 and Gata2 regulates the development of endothelial and hematopoietic lineages. Developmental Biol., 389:208-218.,
Grants and Patents

Grants and Patents


Defined the role for the GABA system as a regulator of the endocrine and exocrine pancreas. Issued: 1999