Kevin Mayo, PhD

My research in structural biology is aimed at understanding cell adhesion at the molecular level where protein-protein and protein-carbohydrate interactions are critical. Biomolecular conformations and interactions are analyzed primarily by using high resolution NMR spectroscopy, circular dichrosim spectropolarimetry and computer modeling. As models for these interactions, for example, we are studying the solution conformations of platelet factor-4 cytokine family proteins and haparin-derived short-chain glycosaminoglycans. We also are interested in studying protein/peptide dynamics and intra- and intermolecular forces which stabilize native structure. In collaboration with Drs. Jim McCarthy and Leo Furcht, we are identifying cell adhesion - promoting peptides derived, for example, from fibronectin, laminin and type IV collagen. Computer models of these structures then allow us to design constrained peptides which have the same conformation and similar biologic activity. Ultimately, my work will aid in the rational design of pharmaceutical drugs which help to control the spread of cancer, to combat stroke and heart disease, or to reduce viral infection.