David Potter, MD, PhD
Professor of Medicine, Division of Hematology, Oncology and Transplantation

Contact Info
Professor of Medicine, Division of Hematology, Oncology and Transplantation
Faculty and Preceptor, Microbiology, Immunology and Cancer Biology (MICaB) Ph.D. Graduate Program
Preceptor, Medical Scientist Training Program (Combined MD/PhD Training Program)
Hematologist / Oncologist
Medical School, Johns Hopkins University, Baltimore, MD
Residency, Stanford University Medical Center, Stanford, CA
Fellowship, Tufts New England Medical Center, Boston, MA
Fellowship, Brigham and Women’s Hospital, Boston, MA
PhD, Johns Hopkins University, Baltimore, MD
Postdoctoral Fellow, M.I.T. Center for Cancer Research
Summary
Awards & Recognition
Professional Associations
Research
Research Summary/Interests
- Novel therapeutics for breast cancer
Regulation of calpain proteases and their roles in cytoskeletal remodeling; the roles of cytochrome P450 in breast cancer progression
Three enzymatic pathways of arachidonic acid metabolism, involving cyclooxygenases, lipoxygenases and epoxygenases, have been identified in mammalian cells, but only the first two have been mechanistically linked to human cancer. The HIV protease inhibitor ritonavir is a potent inhibitor of epoxygenases that arrests the growth of breast cancer xenografts, but its mechanism of action is unknown. Epoxygenases promote the production of epoxyeicosatrienoic acids (EET’s) that activate Akt kinase. Our studies seek to determine whether epoxygenases are cancer therapeutic targets. The hypothesis to be tested is that epoxygenase activation promotes breast cancer progression by promoting Akt phosphorylation and cancer cell survival. Based on our observations we are asking the following questions: What are the molecular mechanisms by which epoxygenases cause growth dysregulation in breast cancer? Do epoxygenases enhance the transforming activities of oncogenes in mammary carcinoma? Do epoxygenase pathways require Hsp90 activity for cancer cell survival? Targeted lipidomics will be used to assay EET regio- and stereoisomers. These studies will promote further development of epoxygenases as targets for breast cancer therapeutics.
Research Funding Grants
Role: Principal Invetigator, Breast Cancer Research Program Grant, Department of Defense CDMRP
Grant Title: Potentiation of immune checkpoint blockade by inhibition of epoxyeicosatrienoic acid driven tumor respiration
Clinical
Clinics
Breast Center
Board Certifications
- American Board of Internal Medicine - Oncology
Clinical Interests
Novel therapeutics for breast cancer