Joan Beckman, MD, PhD

I am a dedicated physician-scientist who is passionate about caring for patients with benign hematologic conditions. I have a clinical interest in patients with acquired and congenital bleeding disorders as well as patients with anemia. I conduct translational research in the molecular and cellular mechanisms driving inflammation-induced pathology in endothelial cells and blood vessels My current research focuses on evaluating the contribution of red blood cell and endothelial cell interactions in JAK2 V617F and CALR+ myeloproliferative neoplasm patients. 

• American Society of Hematology Travel Award (2014, 2008)
• P.E.O. Scholar Award (2011)
• Schmit-Steer Award, Minnesota Medical Foundation, Minneapolis, MN (2010)
• Midwestern Section American Federation for Medical Research Junior Scholar Award (2010, 2009, 2008)
• Central Society for Clinical Research Trainee Travel Award (2010, 2009, 2008)
• J. Thomas Livermore Memorial Award, Minnesota Medical Foundation, Minneapolis, MN (2009)
• Travel Award, 6th International Congress on Heme Oxygenases, Miami Beach, FL (2008)
• Best Poster Award American Physician Scientists Association (APSA)/American Society for Clinical Investigation/Association of American Physicians (ASCI/AAP) Meeting, Chicago, IL (2008)
• Science Award, National Institutes of Health Workshop on Vasculopathy in Sickle Cell Disease, Natcher Conference Center, Bethesda, MD (2008)
• Best Poster Award, Department of Medicine Robert P. Hebbel Research Day (2008)

• Hemostasis & Thrombosis Research Society
• American College of Physicians
• American Society of Hematology
• International Society for Haemostasis and Thrombosis

• Role of endothelial biology in inflammation-mediated coagulation disorders
• Mechanisms to treat and or prevent bleeding and thrombosis in patients with myeloproliferative disorders
• Mechanisms to identify bleeding phenotype in patients with hemophilia
• Role of endothelium in sickle cell pathogensis

• Beckman, J.D., Rollins-Raval, M.A., Raval, J.S., Park, Y.A., Mazepa, M., Ma, A. 2017. Bortezomib for Refractory Immune-Mediated Thrombocytopenia Purpura (ITP). Am J Ther. 25(2):e270-e272. doi:10.1097/MJT.0000000000000517.
• Beckman JD, Holle, LA, Wolberg AS. 2018. Factor XIII Co-Treatment with Hemostatic Agents in Hemophilia A Increases Fibrin ?-Chain Crosslinking.J Thromb Haemost. 16 (1); 131-141.
• Walton BL, Lehmann M, Skorczewski T, Holle LA, Beckman JD, Cribb JA, Mooberry MJ, Wufsus AR, Cooley BC, Homeister JW, Pawlinski R, Falvo MR, Key NS, Fogelson AL, Neeves KB, Wolberg AS.2017. Elevated hematocrit enchances platelet accumulation following vascular injury. Blood. 129: 2537-46.
• Beckman JD, Chen CS, Nguyen J, Thayanithy V, Subramanian S, Steer CJ, Vercellotti GM. 2011. Regulation of Heme Oxygenase-1 Protein Expression by miR-377 in Combination with miR-217. Journal of Biological Chemistry 286(5):3194-3202.
• Belcher JD, Beckman JD, Balla G, Balla J, Vercellotti G. 2010. Heme Degradation and Vascular Injury. Antioxidants & Redox Signaling 12(2):233-248.
• Belcher JD, Vineyard JV, Bruzzone CM, Chen CS, Beckman JD, Nguyen J, Steer CJ, Vercellotti GM. 2010. Heme oxygenase-1 gene delivery by Sleeping Beauty inhibits vascular stasis in a murine model of sickle cell disease. Journal of Molecular Medicine. 88(7):665-675.
• Beckman JD, Belcher JD, Vineyard JV, Chen CS, Nguyen J, Nwaneri MO, O'Sullivan MG, Gulbahce E, Hebbel RP, Vercellotti GM. 2009. Inhaled carbon monoxide reduces leukocytosis in a murine model of sickle cell disease. American Journal of Physiology-Heart and Circulatory Physiology 297(4):H1243-H1253.
• Bruzzone CM, Belcher JD, Schuld NJ, Newman KA, Vineyard J, Nguyen J, Chen C, Beckman JD, Steer CJ, Vercellotti GM. 2008. Quantitative real-time polymerase chain reaction (qRT-PCR) restriction fragment length polymorphism (RFLP) method for monitoring highly conserved transgene expression during gene therapy. Translational Research 152(6):290-297.
• Beckman JD, Grazul-Bilska AT, Johnson ML, Reynolds LP, Redmer DA. 2006. Isolation and characterization of ovine luteal pericytes and effects of nitric oxide on pericyte expression of angiogenic factors. Endocrine 29(3):467-476.