Geoffrey Hart
,
Credentials
PhD

Assistant Professor
Biography

Bio

Dr. Hart performed his dissertation research in the Center for Immunology at the University of Minnesota. Postdoctoral work at the NIH has focused on malaria research. His primary interest is centered on innate immunity, particularly NK cells, in malaria. Using a basic immunology approach, he collaborates with on-going studies in malaria endemic regions of Africa to try to understand protective and pathological mechanisms of this deadly disease.

Research Summary

Basic human immunology Malaria immunity and pathogenesis Antibody mediated immunity Innate inflammation regulation Human immunology of malaria There is no approved vaccine for malaria, and there are still many fundamental unanswered questions for malaria immunity. The Hart lab believes many of these unanswered questions lie where innate immunity intersects with the adaptive immune system. Using a basic immunology approach, they collaborate with on-going studies in malaria endemic regions of Africa. Current malaria projects center around understanding the mechanism of antibody mediated immunity and innate regulatory mechanisms (or lack thereof) in pathological immune responses. We use human subject samples primarily for our studies, and we are also developing novel mouse models to better understand in vivo dynamics where needed.Dr. Hart is a new Primary Investigator in the MICaB program and is excited to train and mentor the next generation of MICaB graduate students. Rotation spots are currently available for the 2017 incoming class. Please apply via email (hart0792@umn.edu).

Clinical Summary

Vaccine development; Immunotherapy