Lin Yee Chen, MD, MS, Published in Annals of Internal Medicine
Lin Yee Chen, MD, MS, has recently been published in the Annals of Internal Medicine. The paper entitled Left Atrial Mechanical Dysfunction and the Risk for Ischemic Stroke in People Without Prevalent Atrial Fibrillation or Stroke presents findings of the Atherosclerosis Risk in Communities (ARIC) study, a prospective community-based cohort study.
This research is paradigm-shifting in identifying a novel risk factor for stroke in people without atrial fibrillation and prior history of stroke.
Lin Yee Chen, MD, MS
Lin Yee Chen, MD, MS, has recently been published in the Annals of Internal Medicine. The paper entitled Left Atrial Mechanical Dysfunction and the Risk for Ischemic Stroke in People Without Prevalent Atrial Fibrillation or Stroke presents findings of the Atherosclerosis Risk in Communities (ARIC) study, a prospective community-based cohort study. A total of 4,917 Black or White ARIC participants were followed from 2011 through 2019. Left atrial strain was measured using speckle-tracking echocardiography at baseline. In fully adjusted models, each standard deviation decrement of the left atrial reservoir and conduit strain was significantly associated with a 40% and 33% higher risk of ischemic stroke, respectively.
Future research is needed to determine whether anticoagulation provides any clinical benefit in reducing the risk of ischemic stroke in individuals with impaired left atrial function in the absence of atrial fibrillation or prior history of stroke.
This study was supported by a grant from the National Heart, Lung, and Blood Institute, National Institutes of Health (R01 HL141288), awarded to Dr. Chen, the senior author of this paper. In addition, the ARIC study has been funded in whole or in part with Federal funds from the National Heart, Lung, and Blood Institute, National Institutes of Health, and Department of Health and Human Services.
