Cardiovascular Research and Rehabilitation Lab (CRRL)
The CRRL is primarily interested in autonomic blood pressure regulation, vascular function and regulation, and the influence of menopause and sex hormones on these systems. Our overarching goal is to identify mechanistic pathways leading to autonomic and vascular (dys)regulation to develop preventative and therapeutic strategies to improve cardiovascular health in females. Ongoing studies in the laboratory are listed below.
- Vasomotor symptoms of menopause and cardiovascular disease
- Autonomic regulation and endothelial function in postmenopausal females with sleep
disturbance - Menopause transition
2025
Stokes, W., Tahsin, C.T., Anselmo, M., Nathe, S., Lee, E., Teshome, S., Vanden Noven, M.,
Carter, J., & Keller-Ross, M. Vasomotor Symptoms of Menopause, Sympathetic Activity, and
Blood Pressure in Postmenopausal Females. (2025). American Journal of Physiology – Heart
and Circulatory Physiology.
Lee, E.J., & Keller-Ross, M.L. Menopause and its Effects on Autonomic Regulation of Blood
Pressure: Insights and Perspectives. (2025). Autonomic Neuroscience: Basic and Clinical.
2024
Asirvatham-Jeyaraj, N., Anselmo, M., Chantigian, D., Larson, M., Lee, E., & Keller-Ross, M.
Influence of endogenous and exogenous hormones on the cardiovascular response to lower
extremity exercise and group III/IV activation in young females. (2024). American Journal of
Physiology – Regulatory, Integrative and Comparative Physiology.
Tahsin, C.T., Anselmo, M., Lee, E., Stokes, W, Fonkoue, Ida, Vanden Noven, M., Carter, J, &
Keller-Ross, M. (2024). Sleep Disturbance and Sympathetic Neural Reactivity in
Postmenopausal Females. American Journal of Physiology – Heart and Circulatory Physiology.
2023
Lee, E.J., Anselmo, M., & Keller-Ross, M.L. (2023). Blood pressure regulation during exercise:
Is age central to the problem? The Journal of Physiology.
Vanden Noven, M.L., Larson, Mia, Lee, E., Reilly, C., Tracy, M.F., & Keller-Ross, M.L. (2023).
Perceptions, Benefits, and Use of Complementary and Integrative Therapies to Treat
Menopausal Symptoms: A Pilot Study. Women’s Health Reports Journal.
2022
Vanden Noven ML., Larson, M., Reilly, C, Tracy, MF., Keller-Ross, ML. Perceptions, Benefits, and Use of Complementary and Alternative Therapies to Treat Menopausal Symptoms: A Pilot Study. J of Women’s Health Reports. (In Press).
Choma EA, Treat-Jacobson DJ, Keller-Ross ML, Wolfson J, Martin L, McMahon SK. Using the RE AIM framework to evaluate physical activity-based fall prevention interventions in older adults with chronic conditions: A systematic review. (2022) Translational Behavioral Medicine:ibac072.
Lee, Emma; Anselmo, Miguel F; Tahsin, Chowdhury Tasnova; Vanden Noven, Marnie; Stokes, William; Carter, Jason R.; Keller-Ross, Manda L (2022) Vasomotor symptoms of menopause, autonomic dysfunction, and cardiovascular disease. Am J Physiol Heart and Circ Physiol. Dec 1;323(6):H1270-H1280.
Anselmo, M, Coffman, S, Vera, K, Lee, E. Keller-Ross, ML. (2022) Baroreflex in Facioscapulohumeral dystrophy Physiological Reports, Apr;10(8):e15277.
Vera, K, McConville, Glazos, A, Stokes, W, Kyba, M, Keller-Ross, ML. (2022) Exercise Intolerance in Facioscapulohumeral Muscular Dystrophy. Med Sci Sports Exerc.
Smith, JR, Joyner, MJ, Curry, TB, Borlaug, BA, Keller-Ross, ML, Van Iterson, EH, Olson, TP. (2022) Locomotor Muscle Group III/IV Afferents Constrain Stroke Volume in Human Heart Failure during Submaximal Exercise. J Appl Physiol,
Anderson, E, Kelly, T, Sharp, A, Keller-Ross, ML, Brunsvold, ME. (2022) Active Rehabilitation in a patient during and after venovenous extracorporeal membrane oxygenation with a diagnosis of COVID-19, a case report. J Acute Care Phys Ther.
2021
Vera, K, McConville, Kyba, M, Keller-Ross, ML. Resting Metabolic Rate in Adults with Facioscapulohumeral Muscular Dystrophy. Appl Physiol, Nutr, Metab (2021). Mar 18. doi: 10.1139/apnm-2020-1119. PMID: 33735584.
Anderson, E, Kelly, T, Sharp, A, Keller-Ross, ML, Brunsvold, ME. (2021) Active Rehabilitation in a patient during and after venovenous extracorporeal membrane oxygenation with a diagnosis of COVID-19, a case report. J Acute Care Phys Ther (In Press).
Keller-Ross, ML, Chantigian, DP, Nemanich, S, Gillick, BT. (2021) Cardiovascular effects of transcranial direct current stimulation and bimanual training in children with cerebral palsy. Pediatric Physical Therapy Journal. Jan 1;33(1):11-16. DOI: 10.1097/PEP.0000000000000762.
2020
Smith, JR, Joyner, MJ, Curry, TB, Borlaug, BA, Keller-Ross, ML, Van Iterson, EH, Olson, TP. In press. Locomotor Muscle Group III/IV Afferents Constrain Stroke Volume and Contribute to Exercise Intolerance in Human Heart Failure. J Physiol.
Keller-Ross, ML, Chantigian, DP, Nemanich, S, Gillick, BT. In press. Cardiovascular effects of transcranial direct current stimulation and bimanual training in children with cerebral palsy. Pediatric Physical Therapy Journal.
Vera, K, McConville, Kyba, M, Keller-Ross, ML. (2020) Sarcopenic obesity in Facioscapulohumeral Muscular Dystrophy. Frontiers in Physiology. doi.org/10.3389/fphys.2020.01008.
Keller-Ross, ML, Cunningham, HA, Carter, JR. (2020) Impact of age and sex on neural cardiovascular responsiveness to cold pressor test in humans. Am J Physiol Regul Integr Comp Physiol. doi: 10.1152/ajpregu.00045.2020
Lalande, S. Cross, TT, Keller-Ross, ML, Morris, N, Johnson, BD, Taylor, BJ (2020) Exercise Intolerance in Heart Failure: Central Role for the Pulmonary System. Exercise and Sport Sciences Reviews. Jan;48(1):11-19.doi: 10.1249/JES.0000000000000208
2019
Keller-Ross ML, Larson, M, Johnson, BD. Skeletal Muscle Fatigability in Heart Failure (2019). Frontiers in Physiology. Feb 21;10:129. doi:10.3389/fphys.2019.00129.
Keller-Ross ML, Chantigian DP, Rich TL, Chen M, Chen CY, Gillick BT. Stability of the cardiovascular response during single-pulse TMS in perinatal stroke. (2019) Brain Stimul. pii: S1935-861X(18)30376-0. doi: 10.1016/j.brs.2018.11.010.
2018
Keller-Ross ML, Chantigian DP, Rich TL, Chen M, Chen CY, Gillick BT. Stability of the cardiovascular response during single-pulse TMS in perinatal stroke. Brain Stimul. (2018) Nov 20. pii: S1935-861X(18)30376-0. doi: 10.1016/j.brs.2018.11.010.
Keller-Ross, ML, Sarkinen, AL, Chantigian, DP, Cross, TJ, Johnson, BD, Olson, TP. Interaction of Chemoreflex and Ergoreflex during Dynamic Exercise in Healthy Adults. (2018). Translational Sports Med. doi.org/10.1002/tsm2.60.
Keller-Ross, ML, Chantigian, Dl, Evanoff, N, Bantle, Anne, Dengel, Donald, Chow, Lisa (2018). VE/VCO2 slope in Lean and Overweight Women and Its Relationship to Lean Leg Mass. Int J Cardiol Heart & Vasculature.
2017
Ann Van de Winckel, Yu-Ting Tseng, Daniel Chantigian, Kaitlyn Lorant, Zinat Zarandi, Jeffrey Buchanan, Thomas A. Zeffiro, Mia Larson, Becky Olson-Kellogg, Jürgen Konczak, Manda L. Keller-Ross (2017). Age-Related Decline of Wrist Position Sense and its Relationship to Specific Physical Training. Front Hum Neuroscie.;11:570.
Wheatley, Courtney M., Baker, Sarah E, Taylor, Bryan J, Keller-Ross, Manda L. Chase, Steven C, Carlson, Alex R., Wentz, Robert J. Snyder, Eric M, Johnson, Bruce D. Influence of Inhaled Amiloride on Lung Fluid Clearance in Response to Normobaric Hypoxia in Healthy Individuals. (2017) High Altit Med & Biol.; 18:4: 343-354.
2016
Keller-Ross, ML, Cowl, A, Cross, TJ, Johnson, BD, Olson, TP. (2016). Ventilation Increases with Lower Extremity Venous Occlusion in Young Adults. Med Sci Sports Exerc, 48 (3): 377-383.
2015
Keller-Ross, ML, Johnson.BD, Carter, R, Joyner, MJJ, Eisenach, J, Curry, T, Olson, TP. (2015). Improved Ventilatory Efficiency with Locomotor Muscle Afferent Inhibition is Strongly Associated with Leg Composition in Heart Failure. Int J Cardiol, 202: 159-166.
Cross TJ, Keller-Ross ML, Issa A, Wentz R. Taylor B, Johnson B. (2015). The impact of averaging window length on the desaturation indexes obtained via overnight pulse oximetry at high altitude. Sleep, 38(8): 1331-1334.
2014
Keller-Ross ML, Joyner, MJ, Johnson, BD, Olson, TP.(2014) Influence of the metaboreflex on arterial blood pressure in heart failure patients. Am Heart J, 167(4):521-8.
Keller-Ross ML, Pruse, J, Yoon T, Schlinder-Delap B, Harkins, A & Hunter SK. (2014) Stress- Induced increase in muscle fatigability of young men and women is predicted by strength but not voluntary activation. J Appl Physiol, 116(7):767-768.
Keller-Ross ML, Schlinder-Delap B, Doyel, R, Larson, G & Hunter SK. (2014) Muscle fatigability is greater in veterans with posttraumatic stress disorder. Med Sci Sports Exerc, 46(7):1302-13.
2011
Yoon T, Schlinder-Delap B, Keller ML & Hunter SK (2011b). Supraspinal fatigue impedes recovery from a low-intensity sustained contraction in old adults. J Appl Physiol 112, 849- 858.
Keller ML, Pruse, J, Yoon T, Schlinder-Delap B, Harkins, A & Hunter SK (2011). Supraspinal Fatigue in men and women during a low force fatiguing contraction. Med Sci Sports Exerc.43, 1873-1883.
Pereira H, Keller ML (2011). Understanding the mechanisms of neuromuscular fatigue with paired- pulse stimulation. J Physiol 589 (Pt 14), 3533-3544.
2010
Hoeger Bement M, Weyer A, Keller, ML, Harkins AL, Hunter SK (2010) Anxiety and stress can predict pain perception following a cognitive stress. Physiology & Behavior 101: 87-92.
2009
Yoon T, Keller ML, Delap BS , Harkins A, Lepers R, & Hunter SK (2009). Sex differences in response to cognitive stress during a fatiguing contraction. J Appl Physiol: respiratory, environmental and exercise physiology 107: 1486-1496.
Hoeger-Bement M, Rasiarmos R, DiCapo R, Lewis A, Keller ML, Harkins A, Hunter S (2009). The Role of the Menstrual Cycle Phase In Pain Perception Before and After an Isometric Fatiguing Contraction. Eur J Appl Physiol 106: 105-112. (PMID:19189119).
R21 AG080503-01A1, NIH (Keller-Ross - PI): Vasomotor symptoms of menopause and
cardiovascular disease: What is the Link?
Total cost: $413,036
Direct costs: $150,000 annually
Role: PI, 15% effort
9/2023-8/2026
Clinical and Translational Science Institute (CTSI) K to R01 Transition to Independence
Program, University of Minnesota (Keller-Ross - PI): Menopause transition, sex hormone
deficiency and autonomic and vascular function
Total cost: $50,000
Direct costs: $50,000
Role: PI, no paid effort
7/2024-6/2026
U54 AT012307-01, NIH (John Osborn - PI): REVEAL - Research Evaluating Vagal Excitation
and Anatomical Linkages
Total cost: $20,999,097
Direct costs: $5,722,227 annually
Role: Co-I, 20% effort
7/2022-8/2025
Minnesota Spinal Cord Injury and Traumatic Brain Injury Research Grant (Tier 1), Minnesota
Office of Higher Education (Ann Parr - PI): CE-STAND: Cervical epidural stimulation after
neurologic damage
Total cost: $499,746
Direct costs: $284,686 annually
Role: Co-I, 10% effort
7/2022-6/2025
R01 AG085873-01, NIH (Carolyn Bramante - PI): Randomized Double-Blind Placebo-Controlled
Trial EValuating Baricitinib on PERSistent NEurologic and Cardiopulmonary symptoms of Long
COVID (REVERSE-LC)
Total cost: $5,665,215
Direct costs: $4,801,153
Role: Co-I, 10% effort
1/2024-12/2029
Contact
612-624-6534
[email protected]
Office Address:
Division of Physical Therapy
University of Minnesota
603 Children's Rehab Center
MMC 388
420 Delaware St. SE
Minneapolis, MN 55455