Respiratory Physiology and Neuroplasticity Laboratory

The primary mission of the Respiratory Physiology and Neuroplasticity Laboratory is to define how sex hormones (e.g. estrogen, testosterone, etc…) influence respiratory function and the development of respiratory neuroplasticity. Research strategies include behavioral measures of respiratory function, neurophysiological measures of respiratory nerve and muscle output, and cellular and molecular biochemistry. Using a multimodal approach, our studies address fundamental scientific questions from multiple physiological levels. 

  • Publications
  • Funding
  • Publications

    2019

    McIntosh, D., & Dougherty, B. J. (2019). Development of ventilatory long-term facilitation is dependent on estrous cycle stage in adult female rats. Respiratory physiology & neurobiology, 264, 1-7. PMID: 30898577 doi: 10.1016/j.resp.2019.02.006

    2018

    Huxtable, A. G., Kopp, E., Dougherty, B. J., Watters, J. J., & Mitchell, G. S. (2018). Cyclooxygenase enzyme activity does not impair respiratory motor plasticity after one night of intermittent hypoxia. Respiratory physiology & neurobiology, 256, 21-28. PMID: 29233741 doi: 10.1016/j.resp.2017.12.004

    Dougherty, B. J., Terada, J., Springborn, S. R., Vinit, S., MacFarlane, P. M., & Mitchell, G. S. (2018). Daily acute intermittent hypoxia improves breathing function with acute and chronic spinal injury via distinct mechanisms. Respiratory physiology & neurobiology, 256, 50-57. PMID: 28549897 doi: 10.1016/j.resp.2017.05.004

    2017

    Dougherty, B. J., Kopp, E. S., & Watters, J. J. (2017). Nongenomic Actions of 17-β Estradiol Restore Respiratory Neuroplasticity in Young Ovariectomized Female Rats. The Journal of neuroscience : the official journal of the Society for Neuroscience, 37(28), 6648-6660. PMID: 28592693 doi: 10.1523/JNEUROSCI.0433-17.2017

    Navarrete-Opazo, A., Dougherty, B. J., & Mitchell, G. S. (2017). Enhanced recovery of breathing capacity from combined adenosine 2A receptor inhibition and daily acute intermittent hypoxia after chronic cervical spinal injury. Experimental neurology, 287(Pt 2), 93-101. PMID: 27079999 doi: 10.1016/j.expneurol.2016.03.026

    2016

    Dougherty, B. J., Gonzalez-Rothi, E. J., Lee, K. Z., Ross, H. H., Reier, P. J., & Fuller, D. D. (2016). Respiratory outcomes after mid-cervical transplantation of embryonic medullary cells in rats with cervical spinal cord injury. Experimental neurology, 278, 22-6. PMID: 26808660 doi: 10.1016/j.expneurol.2016.01.017

    2015

    Dougherty, B. J., Fields, D. P., & Mitchell, G. S. (2015). Mammalian target of rapamycin is required for phrenic long-term facilitation following severe but not moderate acute intermittent hypoxia. Journal of neurophysiology, 114(3), 1784-91. PMID: 26224775 doi: 10.1152/jn.00539.2015

    Navarrete-Opazo, A., Vinit, S., Dougherty, B. J., & Mitchell, G. S. (2015). Daily acute intermittent hypoxia elicits functional recovery of diaphragm and inspiratory intercostal muscle activity after acute cervical spinal injury. Experimental neurology, 266, 1-10. PMID: 25687551 doi: 10.1016/j.expneurol.2015.02.007

    Lee, K. Z., Sandhu, M. S., Dougherty, B. J., Reier, P. J., & Fuller, D. D. (2015). Hypoxia triggers short term potentiation of phrenic motoneuron discharge after chronic cervical spinal cord injury. Experimental neurology, 263, 314-24. PMID: 25448009 doi: 10.1016/j.expneurol.2014.10.002

    2014

    Gill, L. C., Ross, H. H., Lee, K. Z., Gonzalez-Rothi, E. J., Dougherty, B. J., Judge, A. R., & Fuller, D. D. (2014). Rapid diaphragm atrophy following cervical spinal cord hemisection. Respiratory physiology & neurobiology, 192, 66-73. PMID: 24341999 doi: 10.1016/j.resp.2013.12.006

    Lee, K. Z., Lane, M. A., Dougherty, B. J., Mercier, L. M., Sandhu, M. S., Sanchez, J. C., Reier, P. J., & Fuller, D. D. (2014). Intraspinal transplantation and modulation of donor neuron electrophysiological activity. Experimental neurology, 251, 47-57. PMID: 24192152 doi: 10.1016/j.expneurol.2013.10.016

    2013

    Lee, K. Z., Dougherty, B. J., Sandhu, M. S., Lane, M. A., Reier, P. J., & Fuller, D. D. (2013). Phrenic motoneuron discharge patterns following chronic cervical spinal cord injury. Experimental neurology, 249, 20-32. PMID: 23954215 doi: 10.1016/j.expneurol.2013.08.003

    2012

    Dougherty, B. J., Lee, K. Z., Gonzalez-Rothi, E. J., Lane, M. A., Reier, P. J., & Fuller, D. D. (2012). Recovery of inspiratory intercostal muscle activity following high cervical hemisection. Respiratory physiology & neurobiology, 183(3), 186-92. PMID: 22705013 doi: 10.1016/j.resp.2012.06.006

    Dougherty, B. J., Lee, K. Z., Lane, M. A., Reier, P. J., & Fuller, D. D. (2012). Contribution of the spontaneous crossed-phrenic phenomenon to inspiratory tidal volume in spontaneously breathing rats. Journal of applied physiology (Bethesda, Md. : 1985), 112(1), 96-105. PMID: 22033536 doi: 10.1152/japplphysiol.00690.2011

    2010

    Lee, K. Z., Sandhu, M. S., Dougherty, B. J., Reier, P. J., & Fuller, D. D. (2010). Influence of vagal afferents on supraspinal and spinal respiratory activity following cervical spinal cord injury in rats. Journal of applied physiology (Bethesda, Md. : 1985), 109(2), 377-87. PMID: 20507963 doi: 10.1152/japplphysiol.01429.2009

    2009

    Fuller, D. D., Dougherty, B. J., Sandhu, M. S., Doperalski, N. J., Reynolds, C. R., & Hayward, L. F. (2009). Prenatal nicotine exposure alters respiratory long-term facilitation in neonatal rats. Respiratory physiology & neurobiology, 169(3), 333-7. PMID: 19818419 doi: 10.1016/j.resp.2009.09.015

    Sandhu, M. S., Dougherty, B. J., Lane, M. A., Bolser, D. C., Kirkwood, P. A., Reier, P. J., & Fuller, D. D. (2009). Respiratory recovery following high cervical hemisection. Respiratory physiology & neurobiology, 169(2), 94-101. PMID: 19560562 doi: 10.1016/j.resp.2009.06.014

    2008

    Fuller, D. D., Doperalski, N. J., Dougherty, B. J., Sandhu, M. S., Bolser, D. C., & Reier, P. J. (2008). Modest spontaneous recovery of ventilation following chronic high cervical hemisection in rats. Experimental neurology, 211(1), 97-106. PMID: 18308305 doi: 10.1016/j.expneurol.2008.01.013

  • Funding

    External Sources

    The role of spinal estrogen signaling for post-SCI neuroplasticity
    Sponsor: The Craig H. Neilsen Foundation
    Timeline: August 2020 – July 2022
    Role: Principal Investigator