The Nature Portfolio Journal of Regenerative Medicine has published an original research paper by Rita Perlingeiro, PhD entitled “The adult environment promotes the transcriptional maturation of human iPSC-derived muscle grafts.” In the paper, Dr. Perlingeiro discusses her efforts to discover whether transplanted donor-derived myofibers mature to match adult tissue. She outlines the development of a technique to pinpoint key myogenic changes that occur during the in vitro–to–in vivo transition, confirm developmental maturity, and consequently evaluate their applicability for cell-based therapies.
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