Zhe Chen, PhD

Assistant Professor, Department of Neuroscience

Zhe Chen

Contact Info

Assistant Professor, Department of Neuroscience


Summary

Research

Research Summary/Interests

Molecular mechanism of neural development (neuronal migration, axon guidance, and synapse formation), pathogenesis of neurological disorders (agenesis of corpus callosum, split brain syndrome), and regulation of cell signaling.

Publications

1: Zhang, C, Lai, MB, Pedler, M, Johnson, V, Adams, RH, Petrash, JM, Chen, Z & Junge, HJ 2018 “Endothelial cell-specific inactivation of TSPAN12 reveals pathological consequences of blood-retina barrier defects in an otherwise intact vasculature” Arterioscler Thromb Vasc Biol. 2018;38:00-00. https://doi.org/10.1161/ATVBAHA.118.311689

2: Chen, Z 2018 “Common cues wire the spinal cord: axon guidance molecules that regulate spinal neuron migration” Review. Seminars in Cell & Developmental Biology. 2018 Feb 20. pii: S1084- 9521(17)30302-6. https://doi.org/10.1016/j.semcdb.2017.12.012

3: Zhang, C, Lai, MB, Khandan, L, Chen, Z & Junge, HJ 2017 “Norrin-induced Frizzled4 endocytosis and endo-lysosomal trafficking control retinal angiogenesis and barrier function”. Nature communications. 2017; 8:16050. https://doi.org/10.1038/ncomms16050

4: Lai, MB, Zhang, C, Shi, J, Johnson, V, Khandan, L, McVey, J, Klymkowsky, MW, Chen, Z & Junge, HJ 2017 “TSPAN12 is a Norrin co-receptor that amplifies Frizzled4 ligand selectivity and signaling”. Cell reports. 2017; 19(13):2809-2822. https://doi.org/10.1016/j.celrep.2017.06.004

5: Junge, HJ, Yung, AR, Goodrich, LV & Chen, Z 2016 “Netrin1/DCC signaling promotes neuronal migration in the dorsal spinal cord”. Neural Development. 2016 Oct 26;11(1):19. https://doi.org/10.1186/s13064-016-0074-x

6: Leggere, JC, Saito, Y, Darnell, RB, Tessier-Lavigne, M, Junge, HJ & Chen, Z 2016 “NOVA regulates Dcc alternative splicing during neuronal migration and axon guidance in the spinal cord”. Elife. 2016 May 25;5. pii: e14264. doi: 10.7554/eLife.14264. https://doi.org/10.7554/eLife.14264

7: Saito, Y, Miranda-Rottmann, S, Ruggiu, M, Park, CY, Fak, JJ, Zhong, R, Duncan, JS, Fabella, BA, Junge, HJ, Chen, Z, Araya, R, Fritzsch, B, Hudspeth, AJ & Darnell, RB 2016 “NOVA2-mediated RNA regulation is required for axonal pathfinding during development”. Elife. 2016 May 25;5. pii: e14371. doi: 10.7554/eLife.14371. https://doi.org/10.7554/eLife.14371

8: Johnson, V, Xiang, M, Chen, Z & Junge, HJ 2015 “Neurite mistargeting and inverse order of intraretinal vascular plexus formation precede subretinal vascularization in VLDLR mutant mice”. PLoS ONE. 2015 Jul 15;10(7):e0132013. https://doi.org/10.1371/journal.pone.0132013

9: Tamada, A, Kumada, T, Zhu, Y, Matsumoto, T, Hatanaka, Y, Muguruma, K, Chen, Z, Tanabe, Y, Torigoe, M, Yamauchi, K, Oyama, H, Nishida, K & Murakami, F 2008 “Crucial roles of Robo proteins in midline crossing of cerebellofugal axons and lack of their up-regulation after midline crossing”. Neural Development. Nov 5;3:29. https://doi.org/10.1186/1749-8104-3-29

10: Chen, Z, Gore, BB, Long, H, Ma, L & Tessier-Lavigne, M 2008 “Alternative splicing of the Robo3 axon guidance receptor governs the midline switch from attraction to repulsion”. Neuron. May 8;58(3):325-32. https://doi.org/10.1016/j.neuron.2008.02.016