Harald Junge

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Credentials

PhD

Bio

The major goals of the Junge laboratory are to understand neurovascular signaling in the eye and visual system using the mouse as a model system. Areas of focus are regulation of the blood-retina barrier and retinal angiogenesis by neural signals, how the pathways under study function at the molecular level, and the application of novel transgenic mouse models to study ocular disease. We use integrated approaches including mouse genetics, cell-based assays, molecular manipulations (e.g., CRISPR/Cas9), RNA-Seq, and proteomics to understand processes at cellular, developmental, and disease levels.

Research Summary

Neurovascular interactions Blood-retina barrier Retinal angiogenesis Retinopathies, Familial exudative vitreoretinopathy Norrin and Wnt signaling Classical complement system