Louise Evans, Ph.D.

Research Assistant Professor,

Louise Evans

Contact Info

levans@umn.edu

Mailing Address:
Cancer and Cardiovascular Research Building (CCRB)
2231 6th St. S.E.
Minneapolis, MN 55455

Research Assistant Professor


PhD, Molecular Physiology (Renal), University of Edinburgh, Edinburgh, UK, 2012

MSc (Distinction), Cardiovascular Disease, University of Edinburgh, Edinburgh, UK, 2008

MSci (First Class), Pharmacology, University of Bristol, Bristol, UK

Summary

Awards & Recognition

2017   Best Postdoctoral Fellow Poster Award, Cardiovascular Center Research Retreat, Medical College of Wisconsin.

2016   Kidney Council New Investigator Award, American Heart Association, Hypertension Scientific Sessions, Orlando, Florida.

2016   Selected Co-Chair “Salt and Hypertension”, American Heart Association, Hypertension Scientific Sessions, Orlando, Florida.

2016   Featured in AHA Connections Summer issue, “Recognizing Excellence in Research”.

2016  Trainee Travel Award, SRC Renal Hemodynamics Conference, Big Sky, Montana.

2016   Selected Co-Chair “Advances in Renal Physiology II”, Experimental Biology, San Diego, California.

2016   Highest ranking abstract “Advances in Renal Physiology II”, Experimental Biology, San Diego, California.

2015   Excellence in Science Postdoc Award, Medical College of Wisconsin.

2015   Postdoctoral Research Poster Award Winner, Medical College of Wisconsin Research Day.

2015   Hypertension Council New Investigator Award, American Heart Association, Hypertension Scientific Sessions, Washington D.C.

2015   Top 10% Scoring Abstract at American Heart Association Specialty Conferences, American Heart Association, Best of AHA Specialty Conferences.

2015   British Heart Foundation Research Excellence International Travel Award.

2015   Professional Development Travel Award, Medical College of Wisconsin.

Research

Research Funding Grants

2018-2019  Medical College of Wisconsin Research Affairs Committee New Faculty Pilot Grant, Medical College of Wisconsin, $25,000

2017-2020  American Heart Association Scientist Development Grant, Medical College of Wisconsin, $231,000

2013-2015  American Heart Association Postdoctoral Fellowship, Medical College of Wisconsin, $90,772

2011-2012  British Heart Foundation Fellowship Transition Award, British Heart Foundation Centre for Research Excellence, University of Edinburgh, £38,000

2010  University of Edinburgh Innovation Initiative Grant, British Heart Foundation Centre of Research Excellence, University of Edinburgh, £2,250

2007-2011  British Heart Foundation Ph.D. Studentship, British Heart Foundation Centre of Research Excellence, University of Edinburgh, £108,731

Publications

Books

Evans LC, Cowley AW.Renal Medullary Circulation.Morgan & Claypool Life Sciences. 2015 doi: 10.4199/C00136ED2V01Y201507ISP064

Manuscripts

Accepted

Ivy JR*, Evans LC*, Moorhouse R, Richardson RV, Al-Dujaili EAS, Flatman PW, Kenyon CJ, Chapman KE, Bailey MA. Renal and blood pressure response to a high-salt diet in mice with reduced global expression of the glucocorticoid receptor. *Authors contributed equally. Frontiers in Physiology. 2018. Jul 9;9:848

Evans LC*, Dayton A*, Yang C, Liu P, Kurth T, Woo Ahn K, Komas, S, Stingo FC, Laud PW, Vannucci M, Liang M, Cowley AW Jr. Transcriptomic analysis reveals inflammatory and metabolic pathways which are regulated by renal perfusion pressure in the outer medulla of Dahl-S rats. *Authors contributed equally. Physiol Genomics. 2018. Jun 1;50(6):440-447

Palygin O*, Evans LC*, Cowley AW Jr., Staruschenko A.Acute in vivo analysis of ATP release in rat kidneys in response to changes in renal perfusion pressure.*Authors contributed equally. J Am Heart Assoc. 2017. Sept 12;6(9)

Evans LC, Petrova G, Kurth T, Yang C, Bukowy JD, Mattson DL, Cowley AW Jr.Increased perfusion pressure drives renal T-cell infiltration in the Dahl salt-sensitive rat. Hypertension. 2017. Sep;70(3):543-551

Evans LC, Ivy JR, Wyrwoll C, McNairn JA, Menzies RI, Christensen TH, Al-Dujaili EA, Kenyon CJ, Mullins JJ, Seckl JR, Holmes MC, Bailey MA.Conditional deletion of Hsd11b2 in the brain causes salt appetite and hypertension.Circulation.2016.April 5:133(14):1360-70

Palygin O, Levchenko V, Evans LC, Blass G, Cowley AW Jr, Staruschenko A.Use of enzymatic biosensors to quantify endogenous ATP or H2O2 in the kidney.Journal of Visualized Experiments. 2015. Oct 12;(104).

Wyrwoll C, Keith M, Noble J, Stevenson PL, Bombail V, Crombie S, Evans LC, Bailey MA, Wood E, Seckl JR, Holmes MC.Fetal brain 11?-hydroxysteroid dehydrogenase type 2 selectively determines programming of adult depressive-like behaviors and cognitive function, but not anxiety behaviors in male mice.Psychoneuroendocrinology. 2015. Sep;59:59-70.

Evans LC, Ryan RP, Broadway E, Skelton MM, Kurth T, Cowley AW Jr.Null mutation of the nicotinamide adenine dinucleotide phosphate-oxidase subunit p67phox protects the Dahl-S rat from salt-induced reductions in medullary blood flow and glomerular filtration rate.Hypertension. 2015. Mar;65(3):561-8.

Cowley AW Jr., Moreno C, Jacob HJ, Peterson CB, Stingo FC, Ahn KW, Liu P, Vannucci M, Laud PW, Reddy P, Lazar J, Evans L, Yang C, Kurth T, Liang M.Characterization of biological pathways associated with a 1.37 Mbp genomic region protective of hypertension in Dahl S rats.Physiological Genomics. 2014. Jun 1;46(11):398-410.

Burnstock G, Evans LC, Bailey MA.Purinergic signaling in the kidney in health and disease.Purinergic Signaling. 2014. Mar;10(1)71-101.

Craigie E, Evans LC, Mullins JJ, Bailey MA. Failure to downregulate the epithelial sodium channel causes salt sensitivity in Hsd11b2 heterozygote mice. Hypertension. 2012. Sep;60(3):684-90.

Evans LC, Livingstone DE, Kenyon CJ, Jansen MA, Dear JW, Mullins JJ, Bailey MA. A urine-concentrating defect in 11beta-hydroxysteroid dehydrogenase type 2 null mice. Am J Physiol Renal Physiol. 2012. Aug 15;303(4):F494-502.

Dunbar DR, Khaled H, Evans LC, Al-Dujaili EA, Mullins LJ, Mullins JJ, Kenyon CJ, Bailey MA. Transcriptional and physiological responses to chronic ACTH treatment by the mouse kidney. Physiol Genomics. 2010. Feb 4;40(3):158-66.

Thorneloe KS, Sulpizio AC, Lin X, Figueroa DJ, Clouse AK, McCafferty GP, Chendrimada TP, Lashinger ES, Gordon E, Evans L, Misajet BA, Demarini DJ, Nation JH, Casillas LN, Marquis RW, Votta BJ, Sheardown SA, Xu X, Brooks DP, Laping NJ, Westfall TD. N-((1S)-1-{[4-((2S)-2-{[(2,4-dichlorophenyl)sulfonyl]amino}-3-hydroxypropanoyl)-1-piperazinyl]carbonyl}-3-methylbutyl)-1-benzothiophene-2-carboxamide (GSK1016790A), a novel and potent transient receptor potential vanilloid 4 channel agonist induces urinary bladder contraction and hyperactivity: Part 1. J Pharmacol Exp Ther. 2008. Aug;326(2):432-42

In Review

Bukowy JD, Evans LC, Dayton A, Lombard JH, Solberg-Woods LC, Polichnowski AJ, Beard DA, Cowley AW Jr. Automated assessment of glomerular injury index and spatial injury heterogeneity in trichrome stained kidney sections using convolutional neural nets.

Abstracts

Evans LC, Wollner C, Kurth T, Cowley AW Jr. The Effect of Combined Inhibtion of mTOR1+2 on Sodium Handling in Dahl Salt-Sensitive Rats. FASEB J April 2018 32: 716.3

Kumar V, Evans LC, Kurth T, Wollner C, Cowley AW Jr. Inhibition of mTORC2 Signaling Prevents and Reverses Salt-Induced Hypertension and Kidney Injury in Dahl Salt-Sensitive Rats. FASEB J April 32: 716.2

Kumar V, Evans LC, Wollner C, Kurth T, Cowley AW Jr. Therapeutic Suppression of Mtorc2 Signaling Reduces Salt-induced Hypertension and Kidney Injury in SS Rats. Hypertension. 2017;70:A105

Bukowy JD, Evans LC, Dayton A, Cowley AW Jr. Automated Glomerular Localization in Bright-field, Trichrome-stained Rat Kidneys. FASEB J April 2017 31:1031.2

Chen D, Becker B, Colson J, Jin C, Evans LC, Cowley AW Jr., Geurts A, Pollock DM, Pollock JS. NADPH Oxidase p67phox Subunit Contributes to the Maintenance of Diurnal Blood Pressure Rhythms in Dahl Salt-Sensitive Rats. FASEB J April 2017 31:1026.7

Evans LC, Polichnowski AJ, Cowley AW Jr. The Role of the NADPH Oxidase Subunit p67phox in the Regulation of Renal Blood Flow in Dahl S (SS) Rats. FASEB J April 2016 30:739.7

Evans LC, Petrova G, Kurth T, Mattson DL, Cowley AW Jr. Reversal of Hypertension Stops, but Does Not Reverse, Renal T-cell Infiltration in the Dahl Salt-sensitive Rat. Hypertension. 2016;68:A120

Dayton A, Evans LC, Yang C, Liu P, Woo Ahn K, Bukowy JD, Stingo F, Vannucci M, Laud P, Liang M, Cowley AW Jr., RNA-seq analysis of paired servo-controlled kidneys suggests molecular pathways affected by pressure. FASEB J April 2016 30:771.5

Evans LC, Petrova G, Kurth T, Mattson DL, Cowley AW Jr. Increased Blood Pressure Drives Renal T-cell Infiltration in the Dahl Salt-Sensitive Rat. Hypertension. 2015;66:A103

Palygin O, Evans LC, Staruschenko A, Cowley AW Jr. Role of Renal Interstitial ATP in Pressure Natriuresis/Diuresis Relationship. FASEB J April 2015 29:811.16

Bukowy J, Evans LC, Broadway E, Dayton A, Cowley AW Jr. Supervised and Unsupervised Learning Methods for the Automation of Glomerular Scoring. FASEB JApril 201529:663.9

Evans LC, Peterson C, Stingo F, Woo Ahn K, Liu P, Vannucci M, Laud P, Yang C, Liang M, Cowley AW Jr. Genes revealed by Bayesian graphical model analysis in pathways mediating hypertension are differentially expressed in the renal medulla of Dahl salt-sensitive rats.FASEB J April 2014 28:912.6

Evans LC, Ryan R, Kurth T, Skelton M, Cowley AW Jr. Evaluation of the role of the NAD(P)H oxidase subunit p67phox in the regulation of medullary blood flow in Dahl S rats. FASEB J April 2013 27:704.4

Evans LC, Kenyon C, Mullins J, Holmes M, Bailey M. Targeting of 11?-hydroxysteroid dehydrogenase type 2 (11?HSD2) in the nucleus of the solitary tract (NTS) links salt appetite and hypertension. FASEB J April 2013 27:904.8

Evans LC, Ryan RP, Kurth T, Skelton M, Cowley AW Jr. Evaluation of the Role of the NAD(P)H Oxidase Subunit p67phox in the Regulation of Glomerular Filtration Rate in Dahl Salt-sensitive Rats. Hypertension. 2013;62:A294

Ivy JR, Evans LC, Richardson RV, Flatman PW, Chapman KE, Kenyon CJ, Bailey MA.

Abnormal regulation of NCC in glucocorticoid receptor haploinsufficient mice. FASEB J April 2013 27:911.11

Evans LC, Holmes M, Mullins J, Bailey M. Evaluation of salt appetite in brain specific 11? hydroxysteroid dehydrogenase type 2 knockout (11?HSD2?/?) mice. FASEB J April 2012 26:1069.7

Evans LC, Mullin J, Holmes M, Bailey M. Evaluation of salt appetite in brain specific 11? hydroxysteroid dehydrogenase type 2 knockout mice (11?HSD2-/-). Proc Physiol Soc 27 (2012)

Evans LC, Kenyon C, Mullins J, Holmes M, Bailey M. Evaluation of water turnover and urine concentration in 11? hydroxysteroid dehydrogenase type 2 knockout (11?HSD2?/?) mice. FASEB J April 2011 25:1079.4

Evans LC, Mullins JJ, Kenyon CJ, Bailey MA. Progression of medullary atrophy and a urine concentrating defect in 11?-Hydroxysteroid Dehydrogenase Type 2 Knockout mice. Proc Physiol Soc 19 (2010)

Evans LC, Mullins JJ, Bailey MA. A urine concentrating defect in 11?-Hydroxysteroid Dehydrogenase Type 2 knockout mice. Proc Physiol Soc 15 (2009)