Sunny Chan, PhD

Dr. Sunny Chan is an Assistant Professor in the Department of Pediatrics, Division of Blood and Marrow Transplant & Cellular Therapy. Dr. Chan received his B.Sc. in Pharmacology (1998) and B.A.Sc. in Computer Engineering (2001) from the University of British Columbia, Canada, and Ph.D. in Pharmacology from the Chinese University of Hong Kong in 2005. He did his postdoctoral fellowship at the National Cheng Kung University, Taiwan, and at the University of Minnesota in the laboratory of Dr. Michael Kyba. Dr. Chan joined the faculty of the University of Minnesota in 2015. 

Dr. Chan’s research focuses on regenerative medicine for muscular dystrophies using cardiac and skeletal myogenic progenitors derived from pluripotent stem cells. He is developing methods to model cardiopharyngeal mesoderm, a cell population that forms second heart field and head muscle cells. The goal is to produce cell types appropriate for studying the physiology of muscular dystrophies specific to second heart field and head muscles in vitro and for developing cellular therapy targeting these diseases in vivo. 

A selection of Dr. Chan’s recent publications

Chan SS, Arpke RW, Filareto A, Xie N, Pappas MP, Penaloza JS, Perlingeiro RCR, Kyba M (2018). Skeletal muscle stem cells from PSC-derived teratomas have functional regenerative capacity. Cell Stem Cell 23, 74-85

Chan SS, Hagen HR, Swanson SA, Stewart R, Boll KA, Aho J, Thomson JA, and Kyba M (2016). Development of bipotent cardiac / skeletal myogenic progenitors from MESP1+ mesoderm. Stem Cell Reports 6, 26-34

Chan SS, Chan HH, and Kyba M (2016). Heterogeneity of Mesp1+ mesoderm revealed by single-cell RNA-seq. Biochem Biophys Res Commun 474, 469-475

Bedada FB, Chan SS, Metzger SK, Zhang L, Zhang J, Garry DJ, Kamp TJ, Kyba M, and Metzger JM (2014). Acquisition of a quantitative, stoichiometrically conserved ratiometric marker of maturation status in stem-cell derived cardiac myocytes. Stem Cell Reports 3, 594-605

Chan SS, Shi X, Toyama A, Arpke RW, Dandapat A, Iacovino M, Kang J, Le G, Hagen HR, Garry DJ, and Kyba M (2013). Mesp1 patterns mesoderm into cardiac, hematopoietic, or skeletal myogenic progenitors in a context-dependent manner. Cell Stem Cell 12, 587-601

Click here to see a complete list of Dr. Chan’s studies which have been published by academic and research journals.