Tomoyuki Koga, MD, PhD

Assistant Professor, Department of Neurosurgery

Assistant Professor, Department of Neurosurgery


MD, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Japan

Residency in Neurosurgery, University of Tokyo Hospital and Saitama Medical University Hospital, both in Japan

Fellowships in Neurosurgery, Toranomon Hospital, and at University of Tokyo Hospital, both in Tokyo, Japan

PhD, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Japan

Summary

Prior to joining the University of Minnesota, Dr. Tomoyuki Koga was a postdoctoral researcher at Ludwig Cancer Research in La Jolla, CA. Before that, he was an Assistant Professor of Neuro-Oncology at Saitama Medical University in Saitama, Japan (2011 to 2013); and an Assistant Professor of Neurosurgery at the University of Tokyo in Japan (2007 to 2011).

Professional Associations

  • Society for Neuro-Oncology
  • The Japan Neurosurgical Society
  • The Japanese Congress of Neurological Surgeons
  • Japan Society for Neuro-Oncology
  • International Stereotactic Radiosurgery Society
  • The Japan Society for Hypothalamic and Pituitary Tumors
  • Epilepsy Surgery Society of Japan
  • The Japan Stroke Society

Languages

  • English
  • Japanese

Research

Publications

Publications (most recent)

  1. Parisian A, Koga T, Miki S, Johann PD, Kool M, Crawford JR, Furnari FB. SMARCB1 loss interacts with neuronal differentiation state to block maturation and impact cell stability. Genes Dev, in press
  2. He Y, Li J, Koga T, Ma J, Dhawan S, Suzuki Y, Furnari FB, Prabhu VV, Allen JE, Chen CC. Epidermal Growth Factor Receptor (EGFR) as a molecular determinant of glioblastoma response to dopamine receptor 2 (DRD2) inhibitors. Neuro Oncol,in press (co-first author)
  3. Koga T, Furnari FB, Chen CC. Genome engineering evolves brain tumor modeling. Neurol Med Chir (Tokyo), 15: 329-336, 2020 (co-corresponding author)
  4. Koga T, Chaim IA, Benitez JA, Markmiller S, Parisian AD, Hevner RF, Turner KM, Hessenauer FM, D’Antonio M, Nguyen ND, Saberi S, Ma J, Miki S, Boyer AD, Ravits J, Frazer KA, Bafna V, Chen CC, Mischel PS, Yeo GW, Furnari FB. Longitudinal assessment of tumor development using cancer avatars derived from genetically engineered pluripotent stem cells. Nature Communications, 11: 550, 2020 (co-first author)
  5. Bartek J Jr, Alattar AA, Dhawan S, Ma J, Koga T, Nakaji P, Dusenbery KE, Chen CC. Receipt of brachytherapy is an independent predictor of survival in glioblastoma in the Surveillance, Epidemiology, and End Results database. J Neurooncol, 145: 75-83, 2019
  6. Koga T, Chen CC, Furnari FB. When less is more: Gaining power through gene rearrangement of amplified EGFR. Oncotarget, 10: 2116-2117, 2019
  7. Chowdhry S, Zanca C, Rajkumar U, Koga T, Diao Y. Raviram R, Liu F, Turner K, Yang H, Brunk E, Bi J, Furnari F, Bafna V, Ren B, Mischel PS. NAD metabolic dependency in cancer is shaped by gene amplification and enhancer remodeling. Nature, 569: 570-575, 2019
  8. Ma J, Benitez JA, Li J, Miki S, de Abuqerque CP, Galatro T, Orellana L, Zanca C, Reed R, Boyer A, Koga T, Varki NM, Fenton TR, Marie SKN, Lindahl E, Gahman TC, Shiau AK, Zhou H, DeGroot J, Sulman EP, Cavenee WK, Kolodner RD, Chen CC, Furnari FB. Inhibition of nuclear PTEN tyrosine phosphorylation enhance sensitivity through attenuated DNA repair. Cancer Cell, 35: 504-518, 2019
  9. Koga T, Li B, Figueroa JM, Ren B, Chen CC, Carter BS, Furnari FB. Mapping of Genomic EGFRvIII deletions in glioblastoma: insight into mechanisms and biomarker development. Neuro Oncol, 20: 1310-1320, 2018
  10. Hasegawa H, Hanakita S, Shin M, Koga T, Takahashi W, Nomoto A, Sakuramachi M, Saito N. Single fractionated stereotactic radiosurgery for intracranial meningioma in elderly patients: 25-year experience at a single institution. Oper Neurosurg, 14: 341-350, 2018
  11. Turner KM, Deshpande V, Beyter D, Koga T, Rusert J, Lee C, Li B, Arden KC, Ren B, Nathanson DA, Kornblum HI, Taylor MD, Kaushal S, Cavenee WK, Wechsler-Reya RJ, Furnari FB, Vandenberg SR, Rao PN, Wahl GM, Bafna V, Mischel PS. Extrachromosomal oncogene amplification drives tumor evolution and the development of genetic heterogeneity in human cancer. Nature, 543: 122-125, 2017
  12. Zanca C, Villa GR, Benitez JA, Thorne AH, Koga T, D'Antonio M, Ikegami S, Ma J, Boyer AD, Banisadr A, Jameson NM, Parisian AD, Eliseeva OV, Barnabe GF, Liu F, Wu S, Yang H, Wykosky J, Frazer KA, Verkhusha VV, Isaguliants MG, Weiss WA, Gahman TC, Shiau AK, Chen CC, Mischel PS, Cavenee WK, Furnari FB. Glioblastoma cellular crosstalk converges on NF-?B to attenuate EGFR inhibitor sensitivity. Genes Dev, 31: 1212-1227, 2017
  13. Hasegawa H, Hanakita S, Shin M, Shojima M, Koga T, Takahashi W, Sakuramachi M, Nomoto AK, Saito N. Long-term outcomes of single session stereotactic radiosurgery for cerebellar arteriovenous malformation, with a median follow up of 10 Years. World Neurosurg, 98: 314-322, 2017
  14. Hanakita S, Shin M, Koga T, Igaki H, Saito N. Risk reduction of cerebral stroke after stereotactic radiosurgery for small unruptured brain arteriovenous malformations. Stroke, 47: 1247-1252, 2016
  15. Hanakita S, Shin M, Koga T, Igaki H, Saito N. Outcomes of volume-staged radiosurgery for cerebral arteriovenous malformations larger than 20 cm3 with more than 3 years of follow-up. World Neurosurg 87: 242-249, 2016
  16. Hanakita S, Koga T, Shin M, Igaki H, Saito N. The long-term outcomes of radiosurgery for arteriovenous malformations in pediatric and adolescent populations. J Neurosurg Pediatr 16: 222-231, 2015
  17. Hanakita S, Koga T, Shin M, Igaki H, Saito N. Application of single-stage radiosurgery for cerebral arteriovenous malformations > 10 cm3. Stroke 42: 3543-3548, 2014
  18. Hanakita S, Koga T, Shin M, Takayanagi S, Mukasa A, Tago M, Igaki H, Saito N. The long-term outcomes of radiosurgery for intracranial hemangioblastomas. Neuro-Oncol 16: 429-433, 2014
  19. Nathanson DA, Gini B, Mottahedeh J, Visnyei K, Koga T, Gomez G, Eskin A, Hwang K, Wang J, Masui K, Paucar A, Yang H, Ohashi M, Zhu S, Wykosky J, Reed R, Nelson SF, Cloughesy TF, James CD, Rao PN, Kornblum HI, Heath JR, Cavenee WK, Furnari FB, Mischel PS. Targeted therapy resistance mediated by dynamic regulation of extrachromosomal mutant EGFR DNA. Science 343: 72-76, 2014
  20. Hanakita S, Koga T, Igaki H, Murakami N, Oya S, Shin M, Saito N. Role of Gamma Knife surgery for intracranial atypical (WHO grade II) meningiomas. J Neurosurg 119: 1410-1414, 2013
  21. Tanaka S, Shin M, Mukasa A, Hanakita S, Saito K, Koga T, Saito N. Stereotactic radiosurgery for intracranial gliomas. Neurosurg Clin N Am 24: 605-612, 2013
  22. Maruyama K, Koga T, Niranjan A, Kondziolka D, Flickinger JC, Lunsford LD. Radiosurgery for brainstem arteriovenous malformation. Prog Neurol Surg 27: 67-72, 2013
  23. Koga T, Maruyama K, Kamada K, Ota T, Shin M, Itoh D, Kunii N, Ino K, Terahara A, Aoki S, Masutani Y, Saito N. Outcomes of diffusion tensor tractography-integrated stereotactic radiosurgery. Int J Radiat Oncol Biol Phys 82:799-802, 2012 (corresponding author)
  24. Koga T, Shin M, Maruyama K, Kamada K, Ota T, Itoh D, Kunii N, Ino K, Aoki S, Masutani Y, Igaki H, Onoe T, Saito N. Integration of corticospinal tractography reduces motor complications after radiosurgery. Int J Radiat Oncol Biol Phys 83:129-133, 2012 (corresponding author)
  25. Usami K, Kawai K, Koga T, Shin M, Kurita H, Suzuki I, Saito N. Delayed complication after Gamma Knife surgery for mesial temporal lobe epilepsy. J Neurosurg 116:1221-1225, 2012
  26. Koga T, Saito N. Efficacy and limitations of stereotactic radiosurgery in the treatment of glioblastoma. Neurol Med Chir (Tokyo) 52:548-552, 2012 (corresponding author)
  27. Koga T, Maruyama K, Tanaka M, Ino Y, Saito N, Nakagawa K, Shibahara J, Todo T. Extended field stereotactic radiosurgery for recurrent glioblastoma. Cancer 118:4193-4200, 2012
  28. Hanakita S, Koga T, Shin M, Shojima M, Igaki H, Saito N. Role of Gamma Knife surgery in the treatment of intracranial dural arteriovenous fistulas. J Neurosurg 117 Suppl:158-163, 2012
  29. Hanakita S, Koga T, Shin M, Shojima M, Igaki H, Saito N. Role of stereotactic radiosurgery in the treatment of high-grade cerebral arteriovenous malformation. Neurol Med Chir (Tokyo) 52:845-851, 2012
  30. Koga T, Shin M, Maruyama K, Kurita H, Kawamoto S, Saito N. Contribution of technological progress, inter-operator difference and experience of operators in gamma knife radiosurgery for arteriovenous malformation. Acta Neurochir (Wien) 153: 879-882, 2011 (corresponding author)
  31. Koga T, Shin M, Terahara A, Saito N. Outcomes of radiosurgery for brain stem arteriovenous malformations. Neurosurgery 69: 45-52, 2011 (corresponding author)
  32. Koga T, Shin M, Saito N. Treatment with high marginal dose is mandatory to achieve long-term control of skull base chordomas and chondrosarcomas by means of stereotactic radiosurgery. J Neurooncol 98: 233-238, 2010 (corresponding author)
  33. Koga T, Shin M, Maruyama K, Terahara A, Saito N. Long-term outcomes of stereotactic radiosurgery for arteriovenous malformations in the thalamus. Neurosurgery 67: 398-403, 2010 (corresponding author)
  34. Koga T, Shin M, Saito N. Role of gamma knife radiosurgery in neurosurgery: past and future perspectives. Neurol Med Chir (Tokyo) 50(9): 737-748, 2010 (corresponding author)
  35. Kunishima K, Shin M, Kunimatsu A, Aoki S, Sasaki H, Koga T, Itoh D, Mori H, Abe O, Ohtomo K, Saito N. Contrast-enhanced magnetic resonance characteristics of arteriovenous malformations after gamma knife radiosurgery: predictors of post-angiographic obliteration. Neurosurgery 67: 100-109, 2010