Darko Boshnakovski, DVM, PhD

Assistant Professor, Department of Pediatrics

Darko Boshnakovski

Contact Info

darko@umn.edu

Office Phone 651-206-2183

Office Address:
CCRB 4-134,
2231 6th St SE,
Minneapolis, MN 55455

Mailing Address:
Department of Pediatrics
MMC 366 Mayo
8366 (Campus Delivery Code)
420 Delaware St S E
Minneapolis, MN 55455

PhD, Hokkaido University Graduate School of Veterinary Medicine, Sapporo, Japan

DVM St. Cyril and Methodius University Faculty of Veterinary Medicine, Skopje, N. Macedonia

Postdoctoral Research, UT Southwestern Medical Center, Dallas, TX

Summary

Dr. Darko Boshnakovski is an Assistant Professor in the Department of Pediatrics, Division of Blood and Marrow Transplantation & Cellular Therapy. His long-running research interest is in tissue regeneration and understanding the molecular mechanism of FSHD and sarcomas.

Dr. Boshnakovski received his DVM from St. Cyril and Methodius University Faculty of Veterinary Medicine. He received his PhD from Hokkaido University Graduate School of Veterinary Medicine and his postdoctoral training at UT Southwestern Medical Center.

Awards & Recognition

  • Emerging Scientist Award, CCRF, 2015
  • Postdoctoral fellowship from FSHD Society, 2008
  • UTSW PDA conference travel Award, 2008

Research

Publications

Bosnakovski, D., Oyler, D., Mitanoska, A., Douglas, M., Ener, E. T., Shams, A. S., & Kyba, M. (2022). Persistent Fibroadipogenic Progenitor Expansion Following Transient DUX4 Expression Provokes a Profibrotic State in a Mouse Model for FSHD. International journal of molecular sciences, 23(4), [1983]. https://doi.org/10.3390/ijms23041983

Chow, L. S., Bosnakovski, D., Mashek, D. G., Kyba, M., Perlingeiro, R. C. R., & Magli, A. (2021). Chromatin accessibility profiling identifies evolutionary conserved loci in activated human satellite cells. Stem Cell Research, 55, [102496]. https://doi.org/10.1016/j.scr.2021.102496

Bosnakovski, D., Gearhart, M. D., Ho Choi, S., & Kyba, M. (2021). Dux facilitates post-implantation development, but is not essential for zygotic genome activation. Biology of reproduction, 104(1), 83-93. https://doi.org/10.1093/biolre/ioaa179

Bosnakovski, D., Ener, E. T., Cooper, M. S., Gearhart, M. D., Knights, K. A., Xu, N. C., Palumbo, C. A., Toso, E. A., Marsh, G. P., Maple, H. J., & Kyba, M. (2021). Inactivation of the CIC-DUX4 oncogene through P300/CBP inhibition, a therapeutic approach for CIC-DUX4 sarcoma. Oncogenesis, 10(10), [68]. https://doi.org/10.1038/s41389-021-00357-4

Bosnakovski, D., Shams, A. S., Yuan, C., da Silva, M. T., Ener, E. T., Baumann, C. W., Lindsay, A. J., Verma, M., Asakura, A., Lowe, D. A., & Kyba, M. (2020). Transcriptional and cytopathological hallmarks of FSHD in chronic DUX4-expressing mice. Journal of Clinical Investigation, 130(5), 2465-2477. https://doi.org/10.1172/JCI133303

Bosnakovski, D., da Silva, M. T., Sunny, S. T., Ener, E. T., Toso, E. A., Yuan, C., Cui, Z., Walters, M. A., Jadhav, A., & Kyba, M. (2019). A novel P300 inhibitor reverses DUX4-mediated global histone H3 hyperacetylation, target gene expression, and cell death. Science Advances, 5(9), [eaaw7781]. https://doi.org/10.1126/sciadv.aaw7781

Click here to see a complete list of Dr. Boshnakovski’s studies which have been published by academic and research journals.