Name: GI Division
Mail: 420 Delaware Street SE, MMC 36, Minneapolis, MN 55455
Dr. Vaughn completed his Internal Medicine residency and Gastroenterology fellowship at Beth-Israel Deaconess Medical Center in Boston. There he developed both clinical and research interests in Inflammatory Bowel Disease. He worked with the IBD Center at BIDMC to study the effect of therapeutic manipulation of the microbiome in Crohn's disease as well as optimizing the management of anti-TNF medications. In addition to his research interests he has worked closely with the medical school teaching students and mentoring physicians in training in clinical and quality improvement research. His main clinical interests include Crohn's disease, Ulcerative Colitis as well as Microscopic colitis and Celiac disease. He also sees patients with recurrent C. difficile colitis. His active areas of research involve clinical trials for IBD.
Dr. Vaughn is actively involved in both clinical and translational research for patient with IBD. The intestinal microbiota has recently been identified as a critical component of many intestinal pathways including immune tolerance and inflammation. Dr. Vaughn is working in collaboration with Dr. Alexander Khoruts to continue to understand how the microbiota functions to induce inflammation or tolerance. Additionally, Dr. Vaughn has been a strong proponent for therapeutic drug monitoring. This includes monitoring drug levels for patient on anti-TNFs such as infliximab and adalimumab. His research demonstrates that by close monitoring of these medication and titration to a therapeutic window, patients have more effective disease control and less chance of developing anti-drug antibodies.He continues to study the effect of therapeutic drug monitoring on antibody development.
Inflammatory Bowel Disease; Clinical trials in IBD; Crohn's Disease; Ulcerative Colitis; Microscopic colitis