Craig Bierle
,
Credentials
PhD
Bio
Craig J. Bierle, PhD, is an Assistant Professor in the Division of Pediatric Infectious Diseases and leads a research laboratory that studies how viral infection during pregnancy affects placental development and function.
Research Summary
Infection is a leading cause of pregnancy loss, premature birth, and intellectual disability in children. Viral infection of the placenta can have devastating consequences on intrauterine development, but ethical and technical barriers to studying human pregnancy have limited our understanding of how to prevent or treat these infections. The Bierle Lab draws on expertise in molecular virology, reproductive immunology, and placental biology to study the pathogenesis of cytomegalovirus and other significant causes of congenital infection. By combining cutting-edge models of trophoblast development, in vivo experimentation, and next-generation sequencing technologies, the group aims to understand how maternal infection at different times in pregnancy affects the placenta and developing offspring, using this information to develop immunomodulatory therapies or preventative vaccines.
External Research Support:
Trophoblast development and placental susceptibility to cytomegalovirus infection (NIH NICHD, R01HD109252, PI)
Microbial-induced maternal factors that influence fetal immune development (NIH NICHD, R01HD113192, Co-I)
Optimizing Immunity and Maternal Host Defense Against Congenital Cytomegalovirus Infection (NIH NICHD, R01HD098866, Co-I)
Defining the viral determinants of cytomegalovirus transplacental transmission (NIH NICHD, R21HD087496, PI)
Education
Fellowships, Residencies, and Visiting Engagements
Honors and Recognition
Contact
Address
Medicine/IDIMLRB/MTRF
2873C (Campus Delivery Code)
2001 6th St SE
Minneapolis, MN 55455