Daniel Guillaume

Interim Department Head, Department of Neurosurgery
Shelley N. Chou Endowed Chair and Vice Chair for Clinical Affairs
Professor, Department of Neurosurgery
Chief, Pediatric Neurosurgery, Masonic Children's Hospital
Co-Chief, Neuroscience Service Line, M Health Fairview


After completing his neurosurgery residency at the University of Iowa Hospital and Clinics, Dr. Guillaume completed two clinical fellowships at the:

  • University of Iowa, working with Dr. Arnold Menezes, a pediatric neurosurgeon and world expert in development and pathologies of the cranial base and craniovertebral junction
  • Centre for Minimally Invasive Neurosurgery, Prince of Wales Hospital and Sydney Children's Hospital in Sydney, Australia, working with Dr. Charles Teo, a pediatric neurosurgeon and pioneer in minimally invasive approaches to the brain. These approaches allow treatment of problems, including hydrocephalus and brain tumors, through a tiny incision, often leading to less pain and a shorter hospital stay after surgery. In many cases, these approaches can successfully treat hydrocephalus, for instance, with avoidance or removal of shunt catheters, and some brain tumors can be removed through the nose or eyebrow avoiding the need for large scalp incisions.

Through his unique training, Dr. Guillaume has developed expertise for managing conditions such as pediatric brain tumors and hydrocephalus, Chiari malformation, and pediatric skull base surgery. He joined the University of Minnesota in 2012 after practicing pediatric neurosurgery for almost six years as a faculty member at Oregon Health & Science University in Portland. Over the years, he has become deeply experienced in caring for children with all types of congenital and acquired neurosurgical problems.

Dr. Guillaume is currently Chief of Pediatric Neurosurgery at the University of Minnesota Masonic Children's Hospital, and Director of the Division of Pediatric Neurosurgery. His interests include advanced treatments of pediatric brain and spinal tumors, minimally invasive surgical approaches, complex hydrocephalus, and Chiari malformation. He has published in numerous journals and books, directed courses on minimally invasive and endoscopic surgical approaches, served as reviewer and co-editor for major neurosurgery and stem cell journals and served as a moderator and scientific program committee member for national pediatric neurosurgical meetings.

Dr. Guillaume was attracted to pediatric neurosurgery because he enjoys caring for children and their families, and is committed to improving the lives of children suffering from neurological problems.


  • MD, University of Iowa Carver College of Medicine
  • Residency in Neurosurgery, University of Iowa Hospitals and Clinics
  • Fellowship in Pediatric and Minimally Invasive Neurosurgery, Prince of Wales Hospital and Sydney Children's Hospital
  • Fellowship in Neurosurgery, University of Iowa
  • Fellowship in Stem Cell Research, University of Wisconsin
  • MS, Neurology/Neurosurgery, McGill University, Montreal, Quebec, Canada
  • BS, University of Iowa

Professional Associations

  • Pituitary Society, 2016 to present
  • American Society of Pediatric Neurosurgeons, 2013 to present
  • Minnesota Neurosurgical Society, 2012 to present
  • American Academy of Pediatrics, 2012 to present
  • International Society for Pediatric Neurosurgery, 2011 to present
  • International Brain Barriers Society, 2008 to present
  • Society for Neuro-oncology, 2008 to present
  • Hydrocephalus Association, 2008 to present
  • AANS/CNS Section of Pediatric Neurosurgery, 2007 to present
  • Children’s Oncology Group, 2007 to present
  • American Association of Neurological Surgeons, 1999 to present
  • Congress of Neurological Surgeons, 1999 to present

Board Certifications

Executive Assistant

Sally Sawyer
Administrative Phone: 612-624-6666 (hit 4 for the Academic Office)
Administrative Email: sallyann@umn.edu
Administrative Fax Number: 612-624-0644

Research Summary

Dr. Guillaume's research is focused on improving diagnosis and therapy for pediatric brain tumors by use of advanced imaging, and efforts to improve delivery of anti-tumor agents by manipulation of the blood-brain barrier. His other ongoing research studies evaluate methods to improve treatment of hydrocephalus using image guidance, and investigate the association of hearing loss in treatments for hydrocephalus.

View PubMed List
View Experts@Minnesota Profile

Clinical Summary

Pediatric neurosurgery, including conditions such as hydrocephalus, spina bifida, craniosynostosis, brain tumors, and spinal deformities and trauma.

Professional Memberships

FDA OOPD, Neurology Oncology Grant Review Panel
FDA OOPD , Neurology Oncology Grant Review Panel
FDA OOPD, Neurology Oncology Grant Review Panel
FDA OOPD, Neurology Oncology Grant Review Panel
CNS, Planning Committee for CNS 2015 Annual Meeting
CNS National Meeting, Scientific Program Committee (Abstract Review Committee, Section on Pediatrics)
SANS, Lifelong Learning Committee Member
AANS National Meeting, Scientific Program Committee (Abstract Review Committee, Section on Pediatrics)
AANS Annual Meeting, Moderator, Pediatric Session
AANS/CNS Section of Pediatric Neurological Surgery, Annual Meeting, Moderator, Hydrocephalus Section
Annual Meeting of the Congress of Neurological Surgeons, Scientific Program Committee and Luncheon Seminar Committee Member
CNS Annual Meeting, Joint section for Pediatric Neurosurgery, Scientific Program Committee (abstracts review committee)
IT advisor, Advisory Board Member



Academic Office Building
2450 Riverside Ave
Minneapolis, MN 55454-1450