Mail: Microbiology Research Building, 1st floor mail room, MMC 2821, 689 23rd Ave S.E., Minneapolis, MN 55455
Dr. Boulware is an infectious disease physician-scientist with formal training in clinical trials, public health, and tropical medicine. Dr. Boulware combines his clinical research with nested basic science investigations into disease pathogenesis to conduct translational research. His primary research interests are in meningitis in resource-limited areas including diagnosis, prevention, treatment, and quality improvement initiatives incorporating cost-effectiveness analyses in order to translate knowledge into improved care. Dr. Boulware's current research is focused on improving the clinical outcomes of HIV-infected persons with cryptococcal meningitis, the second most common AIDS-defining opportunistic infection in Sub-Saharan Africa and the most common cause of adult meningitis. Additionally, Dr. Boulware has been motivated to improve the diagnostics for TB meningitis, and now that TB meningitis can be promptly diagnosed, to also improve the treatment of tuberculous meningitis. Dr. Boulware leads a multidisciplinary, international research team with active research collaborations with partners in Uganda, South Africa, Ethiopia, Brazil, Botswana, the Netherlands, and the United Kingdom.
Reducing HIV-related mortality in people living with AIDS Improving Diagnostics for Meningitis Improving treatments for Cryptococcal meningitis and TB meningitis Preventing avoidable deaths due to subclinical cryptococcosis Clinical Trials for novel meningitis therapeutics and strategies Quality improvement initiatives to improve survival in resource-limited settings Antimicrobial resistance in low and middle income countries Research Projects: Improving Diagnostics and Neurocognitive Outcomes in HIV/AIDS-related Meningitis (R01 NS086312) Phased Implementation of a Public Health Programme: Cryptococcal Screening and Treatment in South Africa. ( R01AI118511) Operational Research for Cryptococcal Antigen Screening (ORCAS) of HIV Patients (U01AI125003) Infectious Disease Training in Clinical Investigation (T32AI055433) Encochleated Oral Amphotericin for Cryptococcal Meningitis Trial TB Meningitis: Evaluating CSF Immunology to Discover Hidden Disease and Potential Immunomodulatory Therapies Redefining Tuberculosis Meningitis with Metagenomics and Host Transcriptomics NIH ACTIV-6 COVID Platform Trial
Central nervous system infections; AIDS-related opportunistic infections; Tropical medicine; Travel medicine; Cost Effectiveness