Demetris Yannopoulos

Professor of Medicine, Center for Resuscitation Medicine
Research Director, Interventional Cardiology
Director, Resuscitation Medicine
Faculty, PhD Program in Integrative Biology and Physiology


Administrator Info
Name: Kathy Vang
Mail: 420 Delaware Street SE
MMC 508 Mayo
8508A (Campus Delivery Code)
Minneapolis, MN 55455

Born in London, UK, Dr. Yannopoulos received his M.D. from the University of Athens in Greece. He completed his medicine residency and general-cardiology fellowship at the University of Minnesota. Following an interventional-cardiology fellowship at Johns Hopkins University in Baltimore, Maryland, Dr. Yannopoulos joined the University of Minnesota faculty in 2008. In March 2010, he became the research director for interventional cardiology.Dr. Yannopoulos is board-certified in internal medicine, cardiology, and interventional cardiology. His clinical interests include emergent cardiac care, coronary-artery disease, and congenital and peripheral intervention.Dr. Yannopoulos's research involves cardiopulmonary resuscitation, hypothermia, and myocardial salvage during acute coronary syndromes. He is considered an authority in cardiorespiratory interactions and hypothermia during CPR. His work in the laboratories of Dr. Keith Lurie (at the University of Minnesota) and Dr. Henry Halperin (at Johns Hopkins University) has helped change current CPR practices.Dr. Yannopoulos is a member of the American Heart Association's CPR guidelines-writing committee, and of the basic life support and research working-group subcommittees. He also serves on the organization committee for the AHA's Resuscitation Science Symposium (ReSS), the largest international conference addressing CPR and emergent cardiac/trauma care.Dr. Yannopoulos is the recipient of two American Heart Association Young Investigator awards (2005 and 2008), and has received AHA and NIH grant support for his work in CPR devices designed to improve bloodflow and clinical outcomes.

Clinical Summary

  • Coronary artery disease and intervention
  • CPR
  • Interventional cardiology
  • Peripheral vascular disease
  • Resuscitation
  • Structural heart disease


MD, University of Athens Medical School

Media Appearances

Novel Cath Lab Transport Strategy May Boost Survival in Cardiac Arrest
EDECMO 36 – Crushing the Nihilism of Cardiac Arrest – with Demetris Yannopoulos

Professional Memberships

AHA, Resuscitation Science Symposium Conference (ReSS), Member of the organization committee
AHA/ECC BLS and Research Working Group Subcommittees, Member
AHA/ECC 2010 CPR and emergent cardiac care guidelines writing committee, Member
Selected Publications

Selected Publications

Yannopoulos, D., Bartos, J. A., Aufderheide, T. P., Callaway, C. W., Deo, R., Garcia, S., Halperin, H. R., Kern, K. B., Kudenchuk, P. J., Neumar, R. W., & Raveendran, G. The Evolving Role of the Cardiac Catheterization Laboratory in the Management of Patients With Out-of-Hospital Cardiac Arrest: A Scientific Statement From the American Heart Association. Circulation 2019, 139(12): e530-e552,
Yannopoulos, D., Bartos, J., Raveendran, G., Walser, E., Connett, J., Murray, T. A., Collins, G., Zhang, L., Kalra, R., Kosmopoulos, M., John, R., Shaffer, A., Frascone, R. J., Wesley, K., Conterato, M., Biros, M., Tolar, J., & Aufderheide, T. P. Advanced reperfusion strategies for patients with out-of-hospital cardiac arrest and refractory ventricular fibrillation (ARREST): a phase 2, single centre, open-label, randomised controlled trial. Lancet (London, England) 2020; 396(10265): 1807-1816,
Abrams, D., MacLaren, G., Lorusso, R., Price, S., Yannopoulos, D., Vercaemst, L., Belohlavek, J., Taccone, F. S., Aissaoui, N., Shekar, K., Garan, A. R., Uriel, N., Tonna, J. E., Jung, J. S., Takeda, K., Chen, Y. S., Slutsky, A. S., Combes, A., & Brodie, D. Extracorporeal cardiopulmonary resuscitation in adults: evidence and implications. Intensive care medicine 2021; 48: 1-15 PMID: 34505911 PMCID: PMC8429884,
Tsangaris, A., Alexy, T., Kalra, R., Kosmopoulos, M., Elliott, A., Bartos, J. A., & Yannopoulos, D. Overview of Veno-Arterial Extracorporeal Membrane Oxygenation (VA-ECMO) Support for the Management of Cardiogenic Shock. Frontiers in cardiovascular medicine 2021, 8, 686558. PMID: 34307500 PMCID: PMC8292640 ,
Aufderheide, T. P., Ii, E., Saleh, H. O., Gutterman, D. D., Weston, B. W., Pepe, P. E., Baker, J. E., Labinski, J., Debaty, G., Tang, L., Szabo, A., Kalra, R., Yannopoulos, D., & Colella, M. R. Change in Out-of-Hospital 12-lead ECG Diagnostic Classification Following Resuscitation from Cardiac Arrest. Resuscitation 2021, 169: P45-52,