Arif Hamid, PhD
Research in the lab is focused on understanding brain substrates for flexible behavioral control and reinforcement learning (RL). We have extensive experience in behavioral, systems, and computational neuroscience and work in the lab combines multiple interdisciplinary approaches to study: (i) the functional properties of key brain decision-circuits, (ii) link identified circuit mechanisms to specific computational operations within normative theoretical frameworks, (iii) to ultimately understand how these circuit- and computational-specializations become leveraged during various behavioral demands.
Our previous scientific contributions have reported novel empirical findings (including dopamine midbrain-forebrain dissociation, and striatal dopamine waves) that have significantly (re)shaped formalizations of dopamine’s role in RL. The lab seeks to build on this trajectory to make deep contributions that integrate experimental findings into multilevel neurocomputational models for tandem and cyclical advances in the simulated and empirical understanding of brain mechanisms for valuation, selection, planning, and execution of behavioral goals.
Zacharoff LA, Hamid AA, Engeland WC, Dubinsky JM, Abnormal Recovery from Acute Stress in Huntingtons Disease Mice. 2021. bioRxiv 2021.07.21.453245; doi: https://doi.org/10.1101/2021.07.21.453245.
Hamid AA. (2021) Dopaminergic Specializations for Flexible Behavioral Control: Linking Levels of Analysis and Functional Architectures. Current Opinion In Behavioral Sciences 41, 131-136 https://doi.org/10.1016/j.
Hamid AA, Frank MJ, Moore CI. (2021) Dopamine Waves as a Mechanism Of Spatiotemporal Credit Assignment. Cell 184, 2733-2749 https://doi.org/10.1016/j.
Zacharoff LA, Hamid AA, Engeland WC, Dubinsky JM. (2021) Abnormal Recovery from Acute Stress in Huntingtons Disease Mice. bioRxiv https://doi.org/10.1101/2021.
Mohebi A, Pettibone JR, Hamid AA, Wong JM, Patriarchi T, Tian L, Kennedy R, Berke JD. (2018) Dissociable Dopamine Dynamics for Learning and Motivation. Nature 570, 65-70 https://doi.org/10.1038/
Hamid AA, Pettibone J, Mabrouk O, Hetrick V, Schmidt S, Vanderweele CM, Kennedy RT, Aragona BJ, And Berke JD. (2016) Mesolimbic Dopamine Signals the Value of Work. Nature Neuroscience 19, 117-126 https://doi.org/10.
Resendez SL, Dome M, Gormley G, Franco D, Nevarez N, Hamid AA, Aragona BJ. (2013) Mu-Opiod Receptors Within Subregions Of The Striatum Mediate Pair Bond Formation Through Parallel Yet Distinct Read Mechanisms. J. Neuroscience, 33(21) 9140-9149 https://doi.org/10.
Mishra A, Hamid AA, Newman EA. (2011). Oxygen Modulation of Neurovascular Coupling In The Rat Retina. PNAS 108(43):17827-31 https://doi.org/10.1073/pnas.