Esther Krook-Magnuson, PhD
Associate Professor, Department of Neuroscience
Associate Professor, Department of Neuroscience
Preceptor, Medical Scientist Training Program (Combined MD/PhD Training Program)
Graduate Program in Neuroscience
Summary
Esther Krook-Magnuson is an Associate Professor in the Department of Neuroscience. Her work focuses on brain circuitry, including the different types of neurons in the brain and their responsiveness to drugs like opioids.
Research
Research Summary/Interests
Selective Neuromodulation
Neuronal networks, diversity, and specificity of function are important to both physiological processes and neurological disorders, including epilepsy. My laboratory seeks to improve our understanding of how cells interact within a network, how networks interact with each other, and the physiological roles of neuronal populations. In this regard, key questions remain in epilepsy research, including what are the principal networks, conditions, and cell types involved in initiating, sustaining, propagating, terminating, and potentially suppressing, seizures. By improving our understanding of these, we improve the prospects of someday reaching the goal of no seizures, no side effects, for all epilepsy patients. My lab uses rodent models of neurological disorders, including temporal lobe epilepsy, and techniques including electrophysiology, optogenetics, immunocytochemistry, transgenic animals, and behavioral experiments to address these fundamental questions
Publications
Streng, ML & Krook-Magnuson, E 2020, ‘The cerebellum and epilepsy’ Epilepsy & Behavior. https://doi.org/10.1016/j.yebeh.2020.106909
Streng, ML & Krook-Magnuson, E 2020, 'Excitation, but not inhibition, of the fastigial nucleus provides powerful control over temporal lobe seizures', Journal of Physiology, vol. 598, no. 1, pp. 171-187. https://doi.org/10.1113/JP278747
Krook-Magnuson, E 2020, 'From Point A to Point B, and What it Means for Epilepsy', Epilepsy Currents, vol. 20, no. 1, pp. 51-53. https://doi.org/10.1177/1535759719889626
Wick, ZC, Tetzlaff, MR & Krook-Magnuson, E 2019, 'Novel long-range inhibitory nNOS-expressing hippocampal cells', eLife, vol. 8. https://doi.org/10.7554/eLife.46816
Wick, ZC & Krook-Magnuson, E 2019, 'Seizing Sequencing Data to Consider Cell and Circuit Complexity' Epilepsy Currents, vol. 19, no. 2, pp. 124-125. https://doi.org/10.1177/1535759719835658
Zeidler, Z, Brandt-Fontaine, M, Leintz, C, Krook-Magnuson, C, Netoff, TI & Krook-Magnuson, E 2018, 'Targeting the mouse ventral hippocampus in the intrahippocampal kainic acid model of temporal lobe epilepsy' eNeuro, vol. 5, no. 4, e0158-18.2018. https://doi.org/10.1523/ENEURO.0158-18.2018
Christenson Wick, Z & Krook-Magnuson, E 2018, 'Specificity, versatility, and continual development: The power of optogenetics for epilepsy research' Frontiers in Cellular Neuroscience, vol. 12, 151. https://doi.org/10.3389/fncel.2018.00151
Richner, TJ & Krook-Magnuson, E 2018, 'Progress toward precise genetic repair in neurons' Epilepsy Currents, vol. 18, no. 2, pp. 121-122. https://doi.org/10.5698/1535-7597.18.2.121
Zeidler, Z & Krook-Magnuson, E 2018, 'Back to the dentate: Network changes of early- and late- born dentate granule cells' Epilepsy Currents, vol. 18, no. 1, pp. 49-50. https://doi.org/10.5698/1535-7597.18.1.49
Krook-Magnuson, E 2017, 'Illuminating seizures: optogenetic approaches to studying networks in epilepsy' Journal of Neuroscience Research, vol. 95, no. 12, pp. 2323-2324. https://doi.org/10.1002/jnr.24147