Esther Krook-Magnuson, PhD

Associate Professor, Department of Neuroscience

Esther Krook-Magnuson

Contact Info

Office Phone 612-301-7747

Lab Phone 612-642-4494

Lab Address:
4-160, 4-164 JacH


Esther Krook-Magnuson is an Associate Professor in the Department of Neuroscience. Her work focuses on brain circuitry, including the different types of neurons in the brain and their responsiveness to drugs like opioids.


Research Summary/Interests

Selective Neuromodulation

Neuronal networks, diversity, and specificity of function are important to both physiological processes and neurological disorders, including epilepsy. My laboratory seeks to improve our understanding of how cells interact within a network, how networks interact with each other, and the physiological roles of neuronal populations. In this regard, key questions remain in epilepsy research, including what are the principal networks, conditions, and cell types involved in initiating, sustaining, propagating, terminating, and potentially suppressing, seizures. By improving our understanding of these, we improve the prospects of someday reaching the goal of no seizures, no side effects, for all epilepsy patients. My lab uses rodent models of neurological disorders, including temporal lobe epilepsy, and techniques including electrophysiology, optogenetics, immunocytochemistry, transgenic animals, and behavioral experiments to address these fundamental questions


Zeidler Z, Hoffmann K, Krook-Magnuson E. HippoBellum: Acute Cerebellar Modulation Alters Hippocampal Dynamics and Function. J Neurosci. 2020 Sep 2;40(36):6910-6926. doi: 10.1523/JNEUROSCI.0763-20.2020.

Streng, ML & Krook-Magnuson, E 2020, ‘The cerebellum and epilepsy’ Epilepsy & Behavior.

Streng, ML & Krook-Magnuson, E 2020, 'Excitation, but not inhibition, of the fastigial nucleus provides powerful control over temporal lobe seizures', Journal of Physiology, vol. 598, no. 1, pp. 171-187.

Krook-Magnuson, E 2020, 'From Point A to Point B, and What it Means for Epilepsy', Epilepsy Currents, vol. 20, no. 1, pp. 51-53.

Wick, ZC, Tetzlaff, MR & Krook-Magnuson, E 2019, 'Novel long-range inhibitory nNOS-expressing hippocampal cells', eLife, vol. 8.

Wick, ZC & Krook-Magnuson, E 2019, 'Seizing Sequencing Data to Consider Cell and Circuit Complexity' Epilepsy Currents, vol. 19, no. 2, pp. 124-125.

Zeidler, Z, Brandt-Fontaine, M, Leintz, C, Krook-Magnuson, C, Netoff, TI & Krook-Magnuson, E 2018, 'Targeting the mouse ventral hippocampus in the intrahippocampal kainic acid model of temporal lobe epilepsy' eNeuro, vol. 5, no. 4, e0158-18.2018.

Christenson Wick, Z & Krook-Magnuson, E 2018, 'Specificity, versatility, and continual development: The power of optogenetics for epilepsy research' Frontiers in Cellular Neuroscience, vol. 12, 151.

Richner, TJ & Krook-Magnuson, E 2018, 'Progress toward precise genetic repair in neurons' Epilepsy Currents, vol. 18, no. 2, pp. 121-122.

Zeidler, Z & Krook-Magnuson, E 2018, 'Back to the dentate: Network changes of early- and late- born dentate granule cells' Epilepsy Currents, vol. 18, no. 1, pp. 49-50.

Krook-Magnuson, E 2017, 'Illuminating seizures: optogenetic approaches to studying networks in epilepsy' Journal of Neuroscience Research, vol. 95, no. 12, pp. 2323-2324.