Prakash Kara, PhD

Professor, Department of Neuroscience

Prakash Kara

Contact Info

pkara@umn.edu

Office Phone 612-626-9558

Lab Phone 612-624-7706

Lab Address:
1-163A CMRR

Summary

Prakash Kara received his PhD from the University of Alabama at Birmingham and postdoctoral training at Harvard Medical School. His previous faculty positions were at the Medical University of South Carolina, as Assistant Professor and then Associate Professor. He came to the University of Minnesota as a Full Professor in 2018 as the first hire in a new initiative, the Medical Discovery Team (MDT) in Optical Imaging and Brain Science.

Research

Research Summary/Interests

The Kara lab solves puzzles in sensory perception and neurovascular coupling in the mammalian brain.

Our long-term goal is to obtain a comprehensive view of how the brain adapts to change in adulthood, development, and disease. The short-term goals of our current projects are to (1) resolve aspects of neural coding of binocular signals in the visual cortex, (2) build microcircuits for neurovascular coupling and (3) determine the underpinnings of functional magnetic resonance imaging (fMRI).

We use two-photon and three-photon imaging, optogenetics, and electrophysiological techniques. More specifically, we assay synaptic and spiking activity along with the responses of individual blood vessels to sensory stimuli and optogenetic activation.

Publications

O’Herron, P, Levy, M, Woodward, JJ & Kara, P 2020, ‘An unexpected dependence of cortical depth in shaping neural responsiveness and selectivity in mouse visual cortex’ eNeuro. https://doi:10.1523/ENEURO.0497-19.2020

O'Herron, P, Summers, PM, Shih, AY, Kara, P & Woodward, JJ 2019, ‘In Vivo Two-Photon Imaging of Neuronal and Brain Vascular Responses in Mice Chronically Exposed to Ethanol’ Alcohol. https://doi.org/10.1016/j.alcohol.2019.12.001

O'Herron, P, Chhatbar, PY, Levy, M, Shen, Z, Schramm, AE, Lu, Z & Kara, P 2016, 'Neural correlates of single-vessel haemodynamic responses in vivo', Nature, vol. 534, no. 7607, pp. 378-382. https://doi.org/10.1038/nature17965

Levy, M, Lu, Z, Dion, G & Kara P 2014, ‘The shape of dendritic arbors in different functional domains of the cortical orientation map’ Journal of Neuroscience, vol. 34, pp. 3231-3236.https://doi.org/10.1523/JNEUROSCI.4985-13.2014

Chhatbar PY & Kara P 2013, ‘Improved blood velocity measurements with a hybrid image filtering and iterative Radon transform algorithm’ Frontiers in Neuroscience, vol. 7, pp. 106. https://doi.org/10.3389/fnins.2013.00106

Levy, M, Schramm, AE & Kara P 2012, ‘Strategies for mapping synaptic inputs on dendrites in vivo by combining two-photon microscopy, sharp intracellular recording, and pharmacology’ Frontiers in Neural Circuits, vol. 6, pp. 101.https://doi.org/10.3389/fncir.2012.00101

O’Herron, P, Shen, Z, Lu, Z, Levy, M, Schramm, AE & Kara P 2012, ‘Targeted labeling of neurons in a specific functional micro-domain of the neocortex by combining intrinsic signal and two-photon imaging’ J. Vis. Exp.,vol.70, pp. 50025.https://doi.org/10.3791/50025

Shen, Z, Lu, Z, Chhatbar, PY, O'Herron, P & Kara P 2012, ‘An artery-specific fluorescent dye for studying neurovascular coupling’ Nature Methods, vol. 9, pp. 273-276.https://doi.org/10.1038/nmeth.1857

Kara, P & Boyd, JD 2009, ‘A micro-architecture for binocular disparity and ocular dominance in visual cortex’ Nature, vol. 458, pp. 627-631. https://doi.org/10.1038/nature07721

Ohki, K, Chung, S, Kara, P, Hübener, M, Bonhoeffer, T & Reid, RC 2006, ‘Highly ordered arrangement of single neurons in orientation pinwheels’ Nature, vol. 442, pp. 925-928.https://doi.org/10.1038/nature05019

Teaching

Courses

NSC 5561

NSCI 3102W