Guisheng Song, PhD

Associate Professor of Medicine, Division of Gastroenterology, Hepatology and Nutrition

Guisheng Song

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Administrative Assistant Name
Alyssa Gagni

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Associate Professor of Medicine, Division of Gastroenterology, Hepatology and Nutrition

Faculty, PhD Program in Molecular, Cellular, Developmental Biology and Genetics

PhD, Chinese Academy of Sciences, Beijing, China

Postdoctoral Scholar, University of California, San Francisco, CA

Postdoctoral Scholar, University of Utah, Salt Lake City, UT


My research focuses mainly on the roles of microRNAs in the pathogenesis of non-alcoholic fatty liver disease (NAFLD), obesity, insulin resistance and liver cancer, with the goal to develop novel therapeutic approaches for these disorders.



  • Raymond Ng#, Guisheng Song#, Garrett Roll, Niels Frandsen, and Holger Willenbring. (2012). A microRNA-21 surge facilitates rapid cyclin D1 translation and cell cycle progression in mouse liver regeneration. J. Clin. Invest. 122(3), 1097-108. (#co-first authors).
  • Jiyoung Lee, Amruta Padhye#, Abhilasha Sharma#, Guisheng Song#, Ji Miao#, Yin-Yuan Mo, Li Wang, and Jongsook Kim Kemper. (2010). A pathway involving FXR and SHP positively regulates hepatic sirt1 levels via miR-34a inhibition. J. Biol. Chem. 285(17), 12604-12611. (#equally contributing authors).
  • Guisheng Song, Amar Deep Sharma, Garrett R. Roll, Raymond Ng, Andrew Y. Lee, Robert H. Blelloch, Niels M. Frandsen, and Holger Willenbring. (2010). MicroRNAs control hepatocyte proliferation during liver regeneration. Hepatology 51(5), 1735-1743.
  • Imene Tabbi-Anneni, Robert Cooksey, Viswanath Gunda, Shiguo Liu, Aubrey Mueller, Guisheng Song, Donald A. McClain, and Lee W. Van Eeden. (2010). Overexpression of nuclear receptor SHP in adipose tissues affects diet-induced obesity and adaptive thermogenesis. Am. J. Physiol. Endocrinol. Metab. 298(5), 961-970.
  • Guisheng Song and Li Wang. (2009). MicroRNA-206 targets Notch3, activates apoptosis, and inhibits tumor cell migration and focus formation. J. Biol. Chem. 284(46), 31921-31927.
  • Guisheng Song and Li Wang. (2009). Nuclear receptor SHP activates miR-206 expression via a cascade dual inhibitory mechanism. PLoS ONE 4(9), e6880.
  • Guisheng Song and Li Wang. (2009). A conserved gene structure and expression regulation of miR-127 and miR-433 in mammals. PLoS ONE 4(11), e7829.
  • Guisheng Song, Kyungtae Park and Li Wang. (2009). Gene expression profiling reveals a diverse array of pathways inhibited by nuclear receptor SHP during adipogenesis. Int. J. Clin. Exp. Pathol. 2(3), 275–285.
  • Guisheng Song and Li Wang. (2008). Transcriptional mechanism for the paired miR-433 and miR-127 genes by nuclear receptors SHP and ERR?. Nucleic Acids Res. 36(18), 5727-5735.
  • Guisheng Song and Li Wang. (2008). MiR-433 and miR-127 arise from independent overlapping primary transcripts encoded by the miR-433-127 locus. PLoS ONE 3(10), e3574.