Sarah Lofgren, MD

Assistant Professor of Medicine, Division of Infectious Diseases and International Medicine

Sarah Lofgren

Contact Info

Mailing Address:
689 SE 23rd Avenue
MC2821 Room 4-109
Microbiology Research Facility
Minneapolis, MN 55455

Administrative Assistant Name
IDIM Admin

Administrative Phone

Administrative Email

Administrative Fax Number

Assistant Professor of Medicine, Division of Infectious Diseases and International Medicine

General ID, HIV

Medical School, Duke University, Durham, NC

Residency, Emory University, Atlanta, GA

Fellowship, University of Minnesota, Minneapolis, MN

Bachelor's Degree, University of Minnesota, Morris, MN


My past focus and future professional goals include researching the pathogenesis of depression in HIV-infected persons, the impact of mental health on HIV care engagement, and HIV treatment outcomes in resource-limited settings of sub-Saharan Africa. During my infectious disease fellowship, I was engaged in clinical and translational research at Makerere University in Uganda and am continuing this work into my faculty position.


  • General Infectious Disease
  • HIV

Awards & Recognition

  • Invited Discussant. Mood disorders in People living with HIV Workgroup Meeting. National Institute of Mental Health. National Institute of Health. (July 17, 2019)
  • Rockville, MD. Conference on Retroviruses and Opportunistic Infections (CROI) Young Investigator award (2017)
  • International Conference on Cryptococcus and Cryptococcosis, Brazil, NIH Young Investigator Award, CSF Immune Responses Associated with Depression Symptoms Following Cryptococcal Meningitis (2017)

Professional Associations

  •  International AIDS Society (2009-present)
  • Infectious Disease Society of America (2015-present)
  • International Society of NeuroVirology (2018-present)
  • Psychoneuroimmunology Research Society (2018-present)


Research Summary/Interests

  • The pathogenesis of depression in HIV-infected persons
  • The impact of mental health on HIV care engagement
  • HIV treatment outcomes in resource-limited settings of sub-Saharan Africa.

Research Funding Grants

  • National Institute of Mental Health (K23MH121220)


  • Rajasingham R, Bangdiwala AS, Nicol MR, Skipper CP, Pastick KA, Axelrod ML, Pullen MF, Nascene AA, Williams DA, Engen NW, Okafor EC, Rini BI, Mayer IA, McDonald EG, Lee TC, Li P, MacKenzie LJ, Balko JM, Dunlop SJ, Hullsiek KH, Boulware DR, Lofgren SM. Hydroxychloroquine as pre-exposure prophylaxis for COVID-19 in healthcare workers: a randomized trial. medRxiv [Preprint]. 2020 Sep 18:2020.09.18.20197327. doi: 10.1101/2020.09.18.20197327. Update in: Clin Infect Dis. 2020 Oct 17;: PMID: 32995820; PMCID: PMC7523161.
  • Lofgren SM, Nicol MR, Bangdiwala AS, Pastick KA, Okafor EC, Skipper CP, Pullen MF, Engen NW, Abassi M, Williams DA, Nascene AA, Axelrod ML, Lother SA, MacKenzie LJ, Drobot G, Marten N, Cheng MP, Zarychanski R, Schwartz IS, Silverman M, Chagla Z, Kelly LE, McDonald EG, Lee TC, Hullsiek KH, Boulware DR, Rajasingham R. Safety of Hydroxychloroquine Among Outpatient Clinical Trial Participants for COVID-19. Open Forum Infect Dis. 2020 Oct 19;7(11):ofaa500. doi: 10.1093/ofid/ofaa500. PMID: 33204764; PMCID: PMC7654376.
  • Boulware DR, Pullen MF, Bangdiwala AS, Pastick KA, Lofgren SM, Okafor EC, Skipper CP, Nascene AA, Nicol MR, Abassi M, Engen NW, Cheng MP, LaBar D, Lother SA, MacKenzie LJ, Drobot G, Marten N, Zarychanski R, Kelly LE, Schwartz IS, McDonald EG, Rajasingham R, Lee TC, Hullsiek KH. A Randomized Trial of Hydroxychloroquine as Postexposure Prophylaxis for Covid-19. N Engl J Med. 2020 Aug 6;383(6):517-525. doi: 10.1056/NEJMoa2016638. Epub 2020 Jun 3. PMID: 32492293; PMCID: PMC7289276.
  • Lofgren SM, Bond DJ, Nakasujja N, Boulware DR. Burden of Depression in Outpatient HIV-Infected adults in Sub-Saharan Africa; Systematic Review and Meta-analysis. AIDS Behav. 2020 Jun;24(6):1752-1764. doi: 10.1007/s10461-019-02706-2. PMID: 31720956; PMCID: PMC7478178.
  • Lofgren S, Hullsiek KH, Morawski BM, Nabeta HW, Kiggundu R, Taseera K, Musubire A, Schutz C, Abassi M, Bahr NC, Tugume L, Muzoora C, Williams DA, Rolfes MA, Velamakanni SS, Rajasingham R, Meintjes G, Rhein J, Meya DB, Boulware DR; COAT and ASTRO-CM Trial Teams. Differences in Immunologic Factors Among Patients Presenting with Altered Mental Status During Cryptococcal Meningitis. J Infect Dis. 2017 Mar 1;215(5):693-697. doi: 10.1093/infdis/jix033. PMID: 28329080; PMCID: PMC5388270.



Clinics and Surgery Center

Board Certifications

  • Internal Medicine
  • Infectious Diseases

Clinical Interests

Native American Care; General Infectious Diseases; HIV