Douglas Mashek



Doug Mashek, PhD, is currently a professor with a primary appointment in the Department of Biochemistry, Molecular Biology and Biophysics (BMBB) and a secondary appointment in the Department of Medicine, Division of Diabetes, Endocrinology and Metabolism. Dr. Mashek earned his B.S. from Iowa State University, M.S. from Michigan State University and Ph.D. from the University of Wisconsin. Doug did his postdoctoral training in Nutritional Biochemistry at the University of North Carolina-Chapel Hill.

Research Summary

Research in the Mashek Lab focuses on the relationship between lipid metabolism and the development of metabolic and aging-related diseases. A primary emphasis is on studies involving lipid droplet biology in the context of non-alcoholic fatty liver disease, Type 2 Diabetes, cancer and aging. A major focus is on understanding how lipid droplets are catabolized and how they communicate within cells to influence cell function. We also conduct pre-clinical and clinical studies to determine how alterations in diet and dietary patterns (fasting, time-restricted feeding, etc.) and exercise alter metabolism to improve health.


PhD, University of Wisconsin

Honors and Recognition

American Society for Nutrition E.L.R. Stokstad Award
American Diabetes Association Basic Science Award
CFANS Distinguished Teaching Award
Novo Nordisk Diabetes Innovation Award
Dannon Nutrition Leadership Institute
American Diabetes Association Junior Faculty Award
NIH/NIDDK National Research Service Award

Professional Memberships

The Obesity Society
American Society for Biochemistry and Molecular Biology
American Society for Nutrition
American Diabetes Association
Selected Publications

Selected Publications

Seibert JT, Najt CP, Heden TD, Mashek DG, Chow LS. Muscle Lipid Droplets: Cellular Signaling to Exercise Physiology and Beyond. Trends in Endocrinology and Metabolism. 2020;8:S1043-2760.,
Zhang E, Cui W, Lopresti, M, Mashek MT, Hu H, Mashek DG. Hepatic PLIN5 signals via SIRT1 to promote autophagy and prevent inflammation during fasting. Journal of Lipid Research 2020;61(3):338-350.,
Cui W, Sathyanarayan A, Lopresti M, Aghajan M, Chen D, Mashek DG. Lipophagy-derived fatty acids undergo extracellular efflux via lysosomal exocytosis. Autophagy 2020;19:1-16.,
Najt CP, Khan SA, Heden TD, Witthuhn BA, Perez M, Mead LE, Franklin MP, Karanja KK, Graham MJ, Mashek MT, Bernlohr DA, Parker L, Chow LS, Mashek DG. Lipid droplet-derived monounsaturated fatty acids traffic via PLIN5 to allosterically activate SIRT1. Molecular Cell 2020;77(4):810-824.,
Chow L, Manoogian E, Alvear A, Fleischer JG, Thor H, Dietsche K, Wang MS, Hodges J, Nair KS, Panda S, Mashek DG. Time restricted eating effects on body composition and metabolic measures in humans who are overweight: a feasibility study. Obesity 2020;28(5):860-869.,