Doug Mashek, PhD, is currently a professor with a primary appointment in the Department of Biochemistry, Molecular Biology and Biophysics (BMBB) and a secondary appointment in the Department of Medicine, Division of Diabetes, Endocrinology and Metabolism. Dr. Mashek earned his B.S. from Iowa State University, M.S. from Michigan State University and Ph.D. from the University of Wisconsin. Doug did his postdoctoral training in Nutritional Biochemistry at the University of North Carolina-Chapel Hill.
Research in the Mashek Lab focuses on the relationship between lipid metabolism and the development of metabolic and aging-related diseases. A primary emphasis is on studies involving lipid droplet biology in the context of non-alcoholic fatty liver disease, Type 2 Diabetes, cancer and aging. A major focus is on understanding how lipid droplets are catabolized and how they communicate within cells to influence cell function. We also conduct pre-clinical and clinical studies to determine how alterations in diet and dietary patterns (fasting, time-restricted feeding, etc.) and exercise alter metabolism to improve health.