Douglas Mashek
,

Credentials

PhD

Professor of BMBB and Medicine (Joint Appointment), Biochemistry, Molecular Biology, and Biophysics

Preceptor, Medical Scientist Training Program (Combined MD/PhD Training Program)

Faculty, PhD Program in Biochemistry, Molecular Biology and Biophysics

Faculty, PhD Program in Integrative Biology and Physiology

Faculty, PhD Program in Molecular, Cellular, Developmental Biology and Genetics

Biography
Publications

Biography

Bio

Administrator Info
Mail: 6-155 Jackson Hall
1214A
321 Church St. SE
Minneapolis, MN 55455

Research Summary

Research in the Mashek laboratory focuses on the relationship between lipid metabolism and the development of metabolic and aging-related diseases. A primary emphasis is on studies involving lipid droplet biology in the context of non-alcoholic fatty liver disease, Type 2 Diabetes, cancer and aging. A major focus is on understanding how lipid droplets are catabolized and how they communicate within cells to influence cell function. We also conduct pre-clinical and clinical studies to determine how alterations in diet and dietary patterns (fasting, time-restricted feeding, etc.) and exercise alter metabolism to improve health.

Education

PhD, University of Wisconsin

Honors and Recognition

American Society for Nutrition E.L.R. Stokstad Award

American Diabetes Association Basic Science Award

CFANS Distinguished Teaching Award

Novo Nordisk Diabetes Innovation Award

Dannon Nutrition Leadership Institute

American Diabetes Association Junior Faculty Award

NIH/NIDDK National Research Service Award

Professional Memberships

The Obesity Society

American Society for Biochemistry and Molecular Biology

American Society for Nutrition

American Diabetes Association

Selected Publications

Seibert JT, Najt CP, Heden TD, Mashek DG, Chow LS. Muscle Lipid Droplets: Cellular Signaling to Exercise Physiology and Beyond. Trends in Endocrinology and Metabolism. 2020;8:S1043-2760.,

Zhang E, Cui W, Lopresti, M, Mashek MT, Hu H, Mashek DG. Hepatic PLIN5 signals via SIRT1 to promote autophagy and prevent inflammation during fasting. Journal of Lipid Research 2020;61(3):338-350.,

Cui W, Sathyanarayan A, Lopresti M, Aghajan M, Chen D, Mashek DG. Lipophagy-derived fatty acids undergo extracellular efflux via lysosomal exocytosis. Autophagy 2020;19:1-16.,

Najt CP, Khan SA, Heden TD, Witthuhn BA, Perez M, Mead LE, Franklin MP, Karanja KK, Graham MJ, Mashek MT, Bernlohr DA, Parker L, Chow LS, Mashek DG. Lipid droplet-derived monounsaturated fatty acids traffic via PLIN5 to allosterically activate SIRT1. Molecular Cell 2020;77(4):810-824.,

Chow L, Manoogian E, Alvear A, Fleischer JG, Thor H, Dietsche K, Wang MS, Hodges J, Nair KS, Panda S, Mashek DG. Time restricted eating effects on body composition and metabolic measures in humans who are overweight: a feasibility study. Obesity 2020;28(5):860-869.,