Karen Armbrust, MD, PhD

Karen Armbrust

Contact Info

Office Address:
University of Minnesota
Department of Ophthalmology & Visual Neurosciences
516 Delaware Street SE
Minneapolis, MN 55455

VA Medical Center
1 Veterans Drive
Minneapolis, MN 55417

MD, University of Minnesota Medical School, 2011

Residency in Ophthalmology, University of Minnesota, 2015

Uveitis and Ocular Immunology Fellowship, National Eye Institute, Bethesda, MD, 2016

PhD, University of Minnesota Medical School, 2009


Dr. Armbrust treats patients with ocular inflammatory disease, including uveitis and scleritis.

Awards & Recognition

1. Clinical Excellence Award Nominee, Minneapolis Veterans Affairs Medical Center, 2018
2. Member in Training Poster Award Finalist, Association for Research in Vision and Ophthalmology (ARVO), 2015.
3. Harry Friedman Research Award, University of Minnesota Department of Ophthalmology, 2014.
4. First Year Resident Teaching Award, Sanford School of Medicine, 2012.




Peer-Reviewed Publications:

1. Kuo, D.E., M.M. Wei, K.R. Armbrust, J.E. Knickelbein, I.Y.L. Yeung, R.B. Nussenblatt, C.C. Chan, H.N. Sen. (2017). Gradient Boosted Decision Tree Classification of Endophthalmitis Versus Uveitis and Lymphoma from Aqueous and Vitreous IL-6 and IL-10 Levels. Journal of Ocular Pharmacologyand Therapeutics 33(4):319-24.
2. Knickelbein, J.E., W.R. Tucker, N. Bhatt, K. Armbrust, D. Valent, D. Obiyor, R.B. Nussenblatt, H.N. Sen.
(2016). Gevokizumab in the Treatment of Autoimmune Non-necrotizing Anterior Scleritis:Results of a Phase I/II Clinical Trial. American Journal of Ophthalmology 172:104-10.
3. Chen, P., C.A. Urzua, J.E. Knickelbein, J.S. Kim, Z. Li, S. Hannes, D. Kuo, B. Chaigne-Delalande, K.Armbrust, W. Tucker, B. Liu, E. Agron, H.N. Sen, R.B. Nussenblatt. (2016). Elevated CD1c+ Myeloid Dendritic Cell Proportions Associate With Clinical Activity and Predict Disease Reactivation in Noninfectious Uveitis. Investigative Ophthalmology & Visual Science 57(4):1765-72.
4. Armbrust, K.R., X. Wang, T.J. Hathorn, S.W. Cramer, G. Chen, T. Zu, T. Kangas, A.N. Zink, G. Oz, T.J. Ebner and L.P.W. Ranum. (2014). Mutant ?-III spectrin causes mGluR1? mislocalization and functional deficits in a mouse model of spinocerebellar ataxia type 5. The Journal of Neuroscience 34(30):
5. Armbrust, K.R., G.S. Kosmorsky, M.S. Lee and D.I. Friedman (2014). A pain in the eye. Survey ofOphthalmology 59(4): 474-7.
6. Lorenzo, D.N., M.-g. Li, S.E. Mische, K.R. Armbrust, L.P.W. Ranum and T.S. Hays (2010). Spectrin mutations that cause spinocerebellar ataxia type 5 impair axonal transport and induce neurodegeneration in Drosophila. The Journal of Cell Biology 189(1): 143-158.
7. Ikeda, Y., K.A. Dick, M.R. Weatherspoon, D. Gincel, K.R. Armbrust, J.C. Dalton, G. Stevanin, A. Durr, C. Zuhlke, K. Burk, H.B. Clark, A. Brice, J.D. Rothstein, L.J. Schut, J.W. Day and L.P.W. Ranum (2006). Spectrin mutations cause spinocerebellar ataxia type 5. Nature Genetics 38(2): 184-190.
8. Clarke, D.J., M. Segal, C.A. Andrews, S.G. Rudyak, S. Jensen, K. Smith and S.I. Reed (2003). S-phase checkpoint controls mitosis via an APC-independent Cdc20p function. Nature Cell Biology 5(10): 928-935.

Book Chapters:
1. Armbrust, K.R. and R.B. Nussenblatt (2018). Blood-Brain Barrier, Immune Privilege, and Autoimmunity, in Retina, 6th edition, Ryan, S.J. (Ed).
2. Knickelbein, J.E., K.R. Armbrust, M. Kim, H.N. Sen, R.B. Nussenblatt. (2017). Pharmacologic Treatment of Noninfectious Uveitis, in Handbook of Experimental Pharmacology 242:231-268.
3. Nicholson, B.P., K.R. Armbrust, H.N. Sen (2017). Wide-Field Imaging in Uveitis, in Multimodal Imaging inUveitis.
4. Armbrust, K.R., M.M. Wei, B.G. Jeffrey, H.N. Sen (2016). Autoimmune Retinopathy, in The Uveitis Atlas.
5. Wei, M.M., K.R. Armbrust, B.G. Jeffrey, H.N. Sen (2016). Cancer-Associated Retinopathy, in The UveitisAtlas.
6. Lee, M.S. and K.R. Armbrust (2012). Perioperative visual loss in ocular and nonocular surgery, in FocalPoints: Clinical Modules for Ophthalmologists 30(10): 1-14.


Board Certifications

American Board of Ophthalmology