Dr. Gülin Öz is a Professor in the Department of Radiology, Center for Magnetic Resonance Research. Following BS degrees in Physics and Chemistry and a PhD in Biochemistry, she continued with postdoctoral training at the CMRR where she later joined the faculty. She uses high field, multi-nuclear magnetic resonance spectroscopy (MRS) to explore neurochemical and metabolic alterations in diseases that affect the brain and spearheaded utilization of neurochemical profiles to assess cerebral changes in patients with neurological diseases and their response to treatment. She focuses on applications of advanced MRS methods in neurodegenerative diseases and diabetes. She further leads efforts to facilitate the use and standardization of robust MRS methodology in the clinical setting.
To develop high and ultrahigh field MRS methodology for human and rodent applications.
To establish in vivo 1H MRS biomarkers of neurodegeneration, in parallel studies with patients and transgenic mouse models, with particular emphasis on movement disorders such as spinocerebellar ataxias and Parkinson's disease. Such biomarkers are expected to facilitate early disease detection and treatment monitoring in pre-clinical and clinical trials.
To determine the effects of diabetes and the hypoglycemic consequences of intensive insulin therapy on brain glucose and glycogen metabolism and to elucidate pathogenic mechanisms of impaired awareness of hypoglycemia using MRS.