Frank Cichocki, PhD
Assistant Professor of Medicine, Division of Hematology, Oncology and Transplantation

Contact Info
Assistant Professor of Medicine, Division of Hematology, Oncology and Transplantation
Faculty, Microbiology, Immunology and Cancer Biology (MICaB) Ph.D. Graduate Program
PhD, University of Minnesota, Minneapolis, MN
Bachelor's Degree, Pennsylvania State University, University Park, PA
Summary
Expertise
Natural killer cell biology
Awards & Recognition
Research
Research Summary/Interests
- NK cell development from hematopoietic precursors
- Transcriptional and epigenetic control of NK cell development
- NK cells in hematopoietic cell transplantation
- Primary immunodeficiencies
Human NK cell biology
Our group has a long-standing interest in the development and differentiation of human natural killer (NK) cells. NK cells represent a lineage of cytotoxic lymphocytes that play key roles in immunosurveillance of virally infected and transformed cells. Our current work is focused on the molecular mechanisms controlling the differentiation, expansion, signaling and function of unique, heterogeneous subsets of adaptive NK cells that arise in response to cytomegalovirus (CMV) infection in healthy individuals and CMV reactivation in hematopoietic cell transplant (HCT) recipients. Our group is also actively exploring pathways important for the efficient generation of highly functional NK cells from induced pluripotent stem cells