Germaine Cornelissen-Guillaume, PhD
Professor, Department of Integrative Biology and Physiology (IBP)

Contact Info
PhD, University of Brussels (Physics), 1976
MS, University of Brussels (Physics, MS, and Science, MEd), 1971
BS, University of Brussels (Physics), 1969
Summary
Awards & Recognition
Research
Research Summary/Interests
Our team studies how blood pressure and heart rate vary in response to stimuli in everyday life, for health surveillance and maintenance.
We use timing according to rhythms (chronobiologic principles) for assessing cardiovascular health, and to detect pre-disease early, so that treatment administration schedules can be optimized to reduce the number of people dying of preventable heart attacks and strokes.
We also explore how solar cycles and changes in the Earth’s radiation environment affect human physiology as their impact has implications for long-term missions in space.
Our extensive archives support research and education in chronobiology as it applies to various fields of medicine.
Publications
Selected Publications
Saka F, Cornelissen G. Chronobiologic assessment of the effect of the DASH diet on blood pressure. Journal of Human Hypertension 2020. DOI: 10.1038/s41371-020-00408-0
Lusczek ER, Parsons LS, Elder J, Harvey SB, Skube M, Muratore S, Beilman G, Cornelissen-Guillaume G. Metabolomics pilot study identifies desynchronization of 24-hour rhythms and distinct intra-patient variability patterns in critical illness: A preliminary report. Front. Neurol. - Sleep Disorders 2020. DOI: 10.3389/fneur.2020.533915
Cornelissen G, Watanabe Y, Siegelova J, Beaty LA, Singh RK, Singh R, Singh RB, Delcourt A, Gumarova L, Gubin D, Chen CH, Otsuka K, for Investigators of the Project on the BIOsphere and the COSmos (BIOCOS) and Members of the Phoenix Study Group. Chronobiologically interpreted ambulatory blood pressure monitoring: past, present, and future. Biological Rhythm Research 2019; 50 (1): 46-62.
Cornelissen G. Metabolic syndrome, adiponectin, sleep, and the circadian system. EBioMedicine 2018; 33: 20-21. doi: 10.1016/j.ebiom.2018.06.013
Otsuka K, Cornelissen G, Kubo Y, Shibata K, Hayashi M, Mizuno K, Ohshima H, Furukawa S, Mukai C. Circadian challenge of astronauts’ unconscious mind adapting to microgravity in space, estimated by heart rate variability. Scientific Reports 2018; DOI:10.1038/s41598-018-28740-z
Sletten J, Cornelissen G, Assmus J, Kiserud T, Albrechtsen S, Kessler J. Maternal exercise, season and sex modify the daily fetal heart rate rhythm. Acta Physiologica 2018; 224 (2): e13093. doi: 10.1111/apha.13093
Cornelissen G, Otsuka K. Chronobiology of aging: a mini-review. Gerontology 2017; 63 (2): 118-128. DOI: 10.1159/000450945
Otsuka K, Cornelissen G, Halberg F. Chronomics and Continuous Ambulatory Blood Pressure Monitoring – Vascular Chronomics: From 7-Day/24-Hour to Lifelong Monitoring. Tokyo: Springer Japan, 2016, 870 + lxxv pp. 10.1007/978-4-431-54631-3.
Lee Gierke C, Cornelissen G. Chronomics analysis toolkit (CATkit). Biological Rhythm Research 2016; 47: 163-181. doi: 10.1080/09291016.2015.1094965
Cornelissen G, Watanabe Y, Otsuka K, Halberg F. Influences of space and terrestrial weather on human physiology and pathology. In: Rosch PJ (Ed.) Bioelectromagnetic and Subtle Energy Medicine, 2nd ed. Boca Raton: CRC Press; 2015. pp. 389-400.
Otsuka K, Cornelissen G, Kubo Y, Hayashi M, Yamamoto N, Shibata K, Aiba T, Furukawa S, Ohshima H, Mukai C. Intrinsic cardiovascular autonomic regulatory system of astronauts exposed long-term to microgravity in space: observational study. npj Microgravity 2015; 1: 15018. doi:10.1038/npjmgrav.2015.18.
Cornelissen G. Cosinor-based rhythmometry. Theoretical Biology and Medical Modelling 2014; 11: 16. doi:10.1186/1742-4682-11-16. 24 pp.