Manda L. Keller-Ross, PhD, DPT, PT
Assistant Professor, Division of Physical Therapy
Assistant Professor, Division of Physical Therapy
Assistant Professor, Division of Rehabilitation Science
Post-doctoral Fellow, Mayo Clinic (Cardiovascular Diseases), 2012-2015
PhD, Marquette University (Integrative Neuromuscular Physiology, Exercise Physiology), 2011
BS, University of Minnesota (Kinesiology), 2002
DPT, Marquette University (Physical Therapy), 2006
Awards & Recognition
The Cardiovascular Research and Rehabilitation Laboratory (CRRL) has a primary interest to investigate limitations in 1) human performance in healthy individuals and 2) exercise intolerance in those with cardiovascular and pulmonary disorders. In addition, we aim to develop novel treatment strategies to improve cardiorespiratory regulation during exercise.
The CRRL uses a multi-system approach as limitations to exercise are dependent on health and training status, exercise type and intensity and age of the individual. The interaction of systems is important for optimal exercise and activity performance. Our Laboratory uses several techniques to quantify heart, lung and skeletal muscle function (i.e. gas exchange, open-circuit acetylene wash-in for cardiac output, non-invasive blood flow measurements, and skeletal muscle strength and fatigue measurements) in healthy individuals and patients with cardiovascular and pulmonary diseases. Because of the disease progression in these patients, they develop skeletal muscle myopathies that limit exercise performance and can contribute to sensations of dyspnea, fatigue and ultimately exercise intolerance. We aim to delineate mechanisms of limitations to exercise and identify optimal treatment strategies to improve exercise and functional capacity and quality of life in clinical populations.
- Mechanisms of exercise intolerance in clinical populations including muscular dystrophy and heart failure
- The contribution of locomotor muscle afferents (group III and IV) to central drive and cardiorespiratory responses during exercise in both healthy adults and those with heart failure
- Autonomic regulation of blood pressure in post-menopausal women
- Mechanisms of increased cardiovascular disease risk in women who enter menopause premature or early
- Use of neuromodulation to reduce blood pressure in patients with hypertension and heart failure
Research Funding Grants
1. Autonomic blood pressure regulation in premature and early menopause (Keller-Ross-PI). American Physiological Society Research Career Enhancement Award 8/2018-8/2020
2. Working group to establish Autonomic Neuromodulation (Osborn-PI) Institute of Engineering Medicine Working Grant University of Minnesota, $5,000 Role: Co-PI
3. Grant-In-Aid, University of Minnesota (Keller-Ross-PI) Autonomic Blood pressure regulation in older premature and early menopause The goal of this GIA is to determine autonomic regulation of blood pressure in older women who entered menopause premature or early 1/2020-6/2020
4. 1 K01 AG064038-01A1, National Institute of Health (Keller-Ross-PI) Autonomic Blood pressure regulation in older premature and early menopause The goal of this Career Development grant to study autonomic blood pressure regulation in premature and early post-menopausal women, 5/2020-4/2025
- Lalande, S. Cross, TT, Keller-Ross, ML, Morris, N, Johnson, BD, Taylor, BJ (2020) Exercise Intolerance in Heart Failure: Central Role for the Pulmonary System.Exercise and Sport Sciences Reviews.Impact factor 4.739; Sum of times cited: 0;Dr. Keller-Ross defined and wrote a section of the review’s intellectual content, conducted the literature research, edited manuscript and approved manuscript.
- Keller-Ross ML, Larson, M, Johnson, BD. Skeletal Muscle Fatigability in Heart Failure (2019). Frontiers in Physiology. Feb 21;10:129. doi:10.3389/fphys.2019.00129.
- Keller-Ross ML, Chantigian DP, Rich TL, Chen M, Chen CY, Gillick BT. Stability of the cardiovascular response during single-pulse TMS in perinatal stroke. (2019) Brain Stimul. pii: S1935-861X(18)30376-0. doi: 10.1016/j.brs.2018.11.010.
- Keller-Ross ML, Chantigian DP, Rich TL, Chen M, Chen CY, Gillick BT. Stability of the cardiovascular response during single-pulse TMS in perinatal stroke. Brain Stimul. (2018) Nov 20. pii: S1935-861X(18)30376-0. doi: 10.1016/j.brs.2018.11.010.
- Keller-Ross, ML, Sarkinen, AL, Chantigian, DP, Cross, TJ, Johnson, BD, Olson, TP. Interaction of Chemoreflex and Ergoreflex during Dynamic Exercise in Healthy Adults. (2018). Translational Sports Med. doi.org/10.1002/tsm2.60.
- Keller-Ross, ML, Chantigian, Dl, Evanoff, N, Bantle, Anne, Dengel, Donald, Chow, Lisa (2018). VE/VCO2 slope in Lean and Overweight Women and Its Relationship to Lean Leg Mass. Int J Cardiol Heart & Vasculature.
- Ann Van de Winckel, Yu-Ting Tseng, Daniel Chantigian, Kaitlyn Lorant, Zinat Zarandi, Jeffrey Buchanan, Thomas A. Zeffiro, Mia Larson, Becky Olson-Kellogg, Jürgen Konczak, Manda L. Keller-Ross (2017). Age-Related Decline of Wrist Position Sense and its Relationship to Specific Physical Training. Front Hum Neuroscie.;11:570.
- Wheatley, Courtney M., Baker, Sarah E, Taylor, Bryan J, Keller-Ross, Manda L. Chase, Steven C, Carlson, Alex R., Wentz, Robert J. Snyder, Eric M, Johnson, Bruce D. Influence of Inhaled Amiloride on Lung Fluid Clearance in Response to Normobaric Hypoxia in Healthy Individuals. (2017) High Altit Med & Biol.; 18:4: 343-354.
- Keller-Ross, ML, Cowl, A, Cross, TJ, Johnson, BD, Olson, TP. (2016). Ventilation Increases with Lower Extremity Venous Occlusion in Young Adults. Med Sci Sports Exerc, 48 (3): 377-383.
- Keller-Ross, ML, Johnson.BD, Carter, R, Joyner, MJJ, Eisenach, J, Curry, T, Olson, TP. (2015). Improved Ventilatory Efficiency with Locomotor Muscle Afferent Inhibition is Strongly Associated with Leg Composition in Heart Failure. Int J Cardiol, 202: 159-166.
- Cross TJ, Keller-Ross ML, Issa A, Wentz R. Taylor B, Johnson B. (2015). The impact of averaging window length on the desaturation indexes obtained via overnight pulse oximetry at high altitude. Sleep, 38(8): 1331-1334.
- Keller-Ross ML, Joyner, MJ, Johnson, BD, Olson, TP.(2014) Influence of the metaboreflex on arterial blood pressure in heart failure patients. Am Heart J, 167(4):521-8.
- Keller-Ross ML, Pruse, J, Yoon T, Schlinder-Delap B, Harkins, A & Hunter SK. (2014) Stress- Induced increase in muscle fatigability of young men and women is predicted by strength but not voluntary activation. J Appl Physiol, 116(7):767-768.
- Keller-Ross ML, Schlinder-Delap B, Doyel, R, Larson, G & Hunter SK. (2014) Muscle fatigability is greater in veterans with posttraumatic stress disorder. Med Sci Sports Exerc, 46(7):1302-13.
- Yoon T, Schlinder-Delap B, Keller ML & Hunter SK (2011b). Supraspinal fatigue impedes recovery from a low-intensity sustained contraction in old adults. J Appl Physiol 112, 849- 858.
- Keller ML, Pruse, J, Yoon T, Schlinder-Delap B, Harkins, A & Hunter SK (2011). Supraspinal Fatigue in men and women during a low force fatiguing contraction. Med Sci Sports Exerc.43, 1873-1883.
- Pereira H, Keller ML (2011). Understanding the mechanisms of neuromuscular fatigue with paired- pulse stimulation. J Physiol 589 (Pt 14), 3533-3544.
- Hoeger Bement M, Weyer A, Keller, ML, Harkins AL, Hunter SK (2010) Anxiety and stress can predict pain perception following a cognitive stress. Physiology & Behavior 101: 87-92.
- Yoon T, Keller ML, Delap BS , Harkins A, Lepers R, & Hunter SK (2009). Sex differences in response to cognitive stress during a fatiguing contraction. J Appl Physiol: respiratory, environmental and exercise physiology 107: 1486-1496.
- Hoeger-Bement M, Rasiarmos R, DiCapo R, Lewis A, Keller ML, Harkins A, Hunter S (2009). The Role of the Menstrual Cycle Phase In Pain Perception Before and After an Isometric Fatiguing Contraction. Eur J Appl Physiol 106: 105-112. (PMID:19189119).