Jin O-Uchi

Assistant Professor of Medicine, Cardiology
Faculty, PhD Program in Integrative Biology and Physiology


Administrator Info
Name: Esther Almeida
Email: ealmeida@umn.edu
Mail: 2231 6th Street SE
Minneapolis, MN 55455

Jin O-Uchi MD, PhD is Assistant Professor of Medicine at the Lillehei Heart Institute, Department of Medicine, Cardiology Division at the University of Minnesota. Dr. O-Uchi received the MD and PhD degree from Jikei University School of Medicine in Japan. He did a postdoctoral fellowship at University of Rochester and worked as an Instructor and a Research Assistant Professor at Thomas Jefferson University. Prior to his position with the U of MN, , he was at Cardiovascular Research Center at Brown University and Rhode island Hospital as an Assistant Professor of Medicine. His research potential has been recognized at a national level by grant awards from NIH/NHLBI, NIH/NIGMS, American Heart Association (AHA) and American Physiological Society (APS). He serves on several editorial boards for publications including Frontiers in Physiology; Frontiers in Cardiovascular Medicine; Frontiers in Genetics; Frontiers in Cell and Developmental Biology; World Journal of Cardiology; Journal of Biochemistry and Molecular Biology Research; and JSM Biochemistry and Molecular Biology. Dr. O-Uchi is a Fellow of Cardiovascular Section of American Physiological Society (FCVS), and a Trustee (elected) of Japanese Physiological Society (JPS). He is a member of the and the American Heart Association (AHA), International Society for Heart Research (ISHR), American Physiological Society (APS), Biophysical Society (BPS), and Cardiac Muscle Society, among others. His research interests include cardiac excitation-contarction/metabolism coupling, heart failure, sudden cardiac death, cardiac channelopathies, and cardiac mitochondrial biology. Come work with us! Visit https://med.umn.edu/lhi/about/jobs to see open positions in the O-Uchi lab.

Research Summary

Arrhythmia Heart Failure Adrenergic Signaling Ion Channels Mitochondria

Clinical Summary

Arrhythmia; Heart Failure


PhD, Jikei University School of Medicine Tokyo
Major: Physiology
MD, Jikei University School of Medicine Tokyo

Honors and Recognition

Selected Speaker for “Featured Topic Session” at Experimental Biology Meeting
Fellow of Cardiovascular Section of American Physiological Society
Finalist, Neonatal Cardiopulmonary Biology Young Investigator Award
Fellow of American Heart Association, American Heart Association Basic Cardiovascular Sciences
Oral Abstract Award, Central Society for Clinical and Translational Research
Shih-Chun Wang Young Investigator Award, American Physiological Society
Finalist, Gary Lopaschuk Young Faculty Award, International Academy of Cardiovascular Sciences
New investigator Award, American Physiological Society, Cell and Molecular Physiology Section
Early Career Investigator Travel Awards, International Society for Heart Research
Richard J. Bing Award, International Society for Heart Research
Finalist, Outstanding Early Career Investigator Award AHA, Basic Cardiovascular Sciences
Hiroshi and Aya Irisawa Memorial Promotion Award Physiological Society of Japan for Young Scientists
Promotion Award, Physiological Society of Japan
Postdoctoral Fellowship Award, American Heart Association

Professional Memberships

Society of General Physiologist (SGP)
Biophysical Society (BPS)
Cardiac Muscle Society
American Physiological Society (APS)
Society of Cardiovascular Anesthesiologists (SCA)
International Academy of Cardiovascular Sciences (IACS)
American Heart Association (AHA)
International Society for Heart Research (ISHR)
Heart Rhythm Society
Central Society for Clinical and Translational Research (CSCTR)
Trustee (elected) of Physiological Society of Japan (2006-present)
Member of Peer Grant Review Committee, American Heart Association (2018-present)
Member of Awards Selection Committee, American Physiological Society, Cardiovascular Section (2018-present)
Ad-hoc Peer Grant Reviewer, Medical Research Council UK Research and Innovation (2019-present)
Member of Career Opportunities in Physiology Committee, American Physiological Society, Cardiovascular Section (2020-present)
Selected Publications

Selected Publications

O-Uchi J*, Komukai K, Kusakari Y, Obata T, Hongo K, Sasaki H, Kurihara S. ?1-Adrenoceptor stimulation potentiates L-type Ca2+ current through Ca2+/calmodulin-dependent PK II (CaMKII) activation in rat ventricular myocytes. Proc Natl Acad Sci U S A. 102(26):9400-9405, 2005. PMID: 15964981 *Corresponding author,
O-Uchi J*, Sasaki H, Morimoto S, Kusakari Y, Shinji H, Obata T, Hongo K, Komukai K, Kurihara S. Interaction of ?1-adrenoceptor subtypes with different G proteins induces opposite effects on cardiac L-type Ca2+ channel. Circ Res. 102:1378-1388, 2008.PMID: 18467629 *Corresponding author.,
O-Uchi J*, Ryu SY, Jhun BS, Hurst S, Sheu SS. Mitochondrial Ion Channels/Transporters as Sensors and Regulators of Cellular Redox Signaling. Antioxid Redox Signal. 21(6):987-1006, 2014. PMID: 24180309. *Corresponding author.,
O-Uchi, J*, Jons, C*, Moss, AJ, Reumann, M, Rice, JJ., Goldenberg, I, Zareba, W, Wilde, AA, Shimizu, W, Kanters, JK, McNitt, S, Hofman, N, Robinson, JL, Lopes, CMB. (*Equal contribution).Use of Mutant-Specific Ion Channel Characteristics for Risk Stratification of Long QT Syndrome Patients. Science Translational Medicine. (2011)3(76):76ra28, 2011. [Cover Image] PMID: 21451124,
O-Uchi J*#, Jhun BS*#, Adaniya SM, Mancini TJ, Landi AK, Cao JL, Xu X, Yoon Y, Choudhary G, Clements RT, Mende U, Sheu SS. Protein kinase D activation induces mitochondrial fragmentation and dysfunction in cardiomyocytes. J Physiol. 596(5):827-855, 2018. PMID: 29313986 (#Equal contribution) *Corresponding authors. [Cover Image],