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The Lang Lab is focused on understanding how core biological processes, such as DNA replication, transcription, and translation, are affected during host-pathogen interactions. We use a multi-disciplinary approach including genetics, biochemistry, cell biology, proteomics, and genomics to answer fundamental questions about the biology of living cells.
"For a complete list of publications, please visit Google ScholarKevin S. Lang and H. Merrikh. (2021) Topological stress is responsible for the detrimental outcomes of head-on replication-transcription conflicts. Cell Reports 34(9), 108797.D. Ma, Z. Wang, C.N. Merrikh, Kevin S. Lang, P. Lu, X. Li, H. Merrikh, Z. Rao, and W. Xu. (2018) Crystal structure of a membrane-bound O-acyltransferase. Nature 562(7726):286-290Kevin S. Lang and H. Merrikh. (2018) The clash of macromolecular titans: replication-transcription conflicts in bacteria. Annual reviews Microbiology 72: 71-88.Kevin S. Lang*, A.N. Hall*, C.N. Merrikh, M. Ragheb H. Tabakh, A.J. Pollack, J.J. Woodward, J.E. Dreifus and H. Merrikh. (2017) Replication-transcription conflicts generate R-loops that orchestrate bacterial stress survival and pathogenesis. Cell 170(4): 787-799.e18. *Equal contribution. F1000 recommended."