Sophia Yohe, MD

Associate Professor, Department of Laboratory Medicine and Pathology

Sophia Yohe

Contact Info

Office Phone 612-273-3098

Mailing Address:
MMC 609 Mayo
420 Delaware St. SE
Minneapolis, MN 55455

Associate Professor, Department of Laboratory Medicine and Pathology


University of Minnesota Medical School, 1995

Tripler Army Medical Center, Honolulu, HI (Internal Medicine), 1998

University of Texas, Health Science Center at San Antonio, TX (Anatomic & Clinical Pathology), 2007

University of Texas, Health Science Center at San Antonio, TX (Hematopathology), 2008

Concordia College, Moorhead, MN, 1991


Dr. Yohe is a hematopathologist and molecular genetic pathologist, director of the Molecular Diagnostics Laboratory, and a member of the Division of Molecular Pathology and Genomics.  In her molecular pathology role, Dr. Yohe works with her colleagues in the Molecular Diagnostics Laboratory and the bioinformatics group at the Minnesota Supercomputing Institute to implement genomic testing into clinical practice. In addition to offering next generation sequencing (NGS) testing for many inherited conditions, the team performs NGS for a number of genes commonly mutated in leukemias, lymphomas, and solid tumors. She is Vice Chair of the College of American Pathologists’ (CAP) Personalized Health Care Committee, which makes recommendations for setting standards in rapidly emerging fields like clinical genomics. She is active in education and is the Molecular Genetic Pathology Fellowship Program Director.


Research Summary/Interests

Dr. Yohe’s research interests include understanding genetic changes and improving detection of minimal residual disease (MRD) in hematopoietic malignancies, like acute myeloid leukemia and myelodysplastic syndrome, using genomic and flow cytometric technologies. One of the challenges in the field is the heterogeneity of the immunophenotype and genetics of these diseases. She has collaborated with her clinical colleagues to show the importance of MRD detection pre-transplant and is pursuing novel methods to detect MRD in acute myeloid leukemia and myelodysplastic syndrome.


  • Mroz P, Michel S, Allen JD, Meyer T, McGonagle EJ, Carpentier R, Vecchia A, Schlichte A, Bishop JR, Dunnenberger HM, Yohe S, Thyagarajan B, Jacobson PA, Johnson SG. Development and implementation of in-house pharmacogenomic testing program at a major academic health system.  Front Genet. 2021 Oct 20;12:712602. doi: 10.3389/fgene.2021.712602.
  • Kao RL, Jacobsen AA, Billington CJ Jr, Yohe SL, Beckman AK, Vercellotti GM, Pearson DR. A case of VEXAS syndrome associated with EBV-associated hemophagocytic lymphohistiocytosis. Blood Cells Mol Dis. 2021 Nov 30;93:102636. doi: 10.1016/j.bcmd.2021.102636.
  • Martinez RJ, Pankratz N, Schomaker M, Daniel J, Beckman K, Karger AB, Thyagarajan B, Ferreri P, Yohe SL, Nelson AC. Prediction of false positive SARS-CoV-2 molecular results in a high-throughput open platform system. J Mol Diagn. 2021 Jun 8:S1525-1578(21)00166-5. doi: 10.1016/j.jmoldx.2021.05.015
  • Oltvai ZN, Harley SE, Koes D, Michel S, Warlick ED, Nelson AC, Yohe S, Mroz P. Assessing acquired resistance to IDH1 inhibitor therapy by full-exon IDH1 sequencing and structural modeling. Cold Spring Harb Mol Case Stud. 2021 Apr 8;7(2):a006007. doi: 10.1101/mcs.a006007.
  • Andrew C Nelson, Benjamin Auch, Matthew Schomaker, Daryl M Gohl, Patrick Grady, Darrell Johnson, Robyn Kincaid, Kylene E Karnuth, Jerry Daniel, Jess K Fiege, Elizabeth J Fay, Tyler Bold, Ryan A Langlois, Kenneth B Beckman, and Sophia Yohe. Analytical validation of a COVID-19 qRT-PCR detection assay using a 384-well format and three extraction methods. bioRxiv, April 5, 2020.doi: [preprint]
  • Gilles SR, Yohe SL, Linden MA, Dolan M, Hirsch B, Grzywacz B. CD161 Is expressed in a subset of T-cell prolymphocytic leukemia cases and Is useful for disease follow-up.Am J Clin Pathol. 2019 Sep 9;152(4):471-478. doi: 10.1093/ajcp/aqz060.
  • Compton CC, Robb JA, Anderson MW, Berry AB, Birdsong GG, Bloom KJ, Branton PA, Crothers JW, Cushman-Vokoun AM, Hicks DG, Khoury JD, Laser J, Marshall CB, Misialek MJ, Natale KE, Nowak JA, Olson D, Pfeifer JD, Schade A, Vance GH, Walk EE, Yohe SL. Preanalytics and precision pathology: Pathology practices to ensure molecular integrity of cancer patient biospecimens for precision medicine. Arch Pathol Lab Med. 2019 Nov;143(11):1346-1363. doi: 10.5858/arpa.2019-0009-SA.
  • Courville EL, Yohe S, Shivers P, and Linden MA. VS38 identifies myeloma cells with dim CD38 expression and plasma cells following daratumumab therapy, which interferes with CD38 detection for 4 to 6 months. American Journal of Clinical Pathology, 2 Nov. 2019,
  • Christine Henzler, Matthew Schomaker, Rendong Yang, Aaron P. Lambert, Rebecca LaRue, Robyn Kincaid, Kenneth Beckman, Teresa Kemmer, Jon Wilson, Sophia Yohe, Bharat Thyagarajan, Andrew C. Nelson. Optimization of a microfluidics-based next generation sequencing assay for clinical oncology diagnostics. Annals of Translational Medicine, 2018; 6 (9).
  • Aqsa Nasir, Livia Hegerova, Ryan Shanley, Veronika Bachanova and Sophia L. Yohe. Clinical significance of low grade follicular lymphoma with high proliferative index. Blood 2017 130:4044.
  • Eckfeldt CE, Randall N, Shanley RM, Yohe S, Bejanyan N, Dolan M, Warlick ED, Verneris MR, Brunstein CG, Wagner JE, Weisdorf DJ, Ustun C. Umbilical cord blood transplantation is a suitable option for consolidation of acute myeloid leukemia with FLT3-ITD. Haematologica. 2016 Aug;101(8):e348-51. doi: 10.3324/haematol.2016.143628. 
  • Courville EL, Yohe S, Chou D, Nardi V, Lazaryan A, Thakral B, Nelson AC, Ferry JA, Sohani AR. EBV-negative monomorphic B-cell post-transplant lymphoproliferative disorders are pathologically distinct from EBV-positive cases and frequently contain TP53 mutations. Mod Pathol. 2016 Oct;29(10):1200-11. doi: 10.1038/modpathol.2016.130.
  • Mettu P, Griffith M, Yohe S, Harrison AR. Nodular lymphocyte predominent Hodgkin lymphoma presenting with unilateral orbital involvement. Ophthal Plast Reconstr Surg. 2016 Mar 24. [Epub ahead of print]
  • Ustun, C., Courville, E. L., DeFor, T., Dolan, M., Randall, N., Yohe, S., Bejanyan, N., Warlick, E., Brunstein, C., Weisdorf, D. J., Linden, M. A. Myeloablative, but not Reduced-Intensity, Conditioning Overcomes the Negative Effect of Flow-Cytometric Evidence of Leukemia in Acute Myeloid Leukemia. Biology of Blood and Marrow Transplantation. 2016; 22(4):669-675.
  • Courville EL*, Singh C*, Yohe S, Linden MA, Naemi K, Berger M, Ustun C, McKenna R, Dolan M. Patients with a history of prior chemotherapy and isolated del(20q) with minimal myelodysplasia have an indolent course. *co-first authors. Am J Clinical Pathol.2016 Apr; 145(4):459-66.
  •  Wilke C, Holtan SG, Sharkey L, DeFor T, Arora M, Premakanthan P, Yohe S, Vagge S, Zhou D, Holter Chakrabarty JL, Mahe M, Corvo R, Dusenbery K, Storme G, Weisdorf DJ, Verneris MR, Hui S. Marrow damage and hematopoietic recovery following allogeneic bone marrow transplantation for acute leukemias: Effect of radiation dose and conditioning regimen. Radiother Oncol. 2016 Jan;118(1):65-71.
  • Yohe S. Molecular Genetic Markers in Acute Myeloid Leukemia. J. Clin. Med. 2015, 4(3), 460-478; doi:10.3390/jcm4030460. Part of special issue: AML in the Molecular Age: From Biology to Clinical Management.
  • Yohe S, Bower M, Onsongo G, Silverstein K, Hauge A, Schomaker M, Zhou Y, Wilson J, Spears M, Bunjer K, Kemmer T, Erdmann J, Beckman B,Thyagarajan B. Clinical validation of targeted next generation sequencing for inherited disorders. Archives of Laboratory Medicine and Pathology 2015 Feb;139(2):204-10.
  • Yohe, Sophia L.; Chenault, Carrie B.; Torlakovic, Emina Emilia; Asplund, Sheryl L.; McKenna, Robert W. Langerhans cell histiocytosis in acute leukemias of ambiguous or myeloid lineage in adult patients: Support for a possible clonal relationship. Modern Pathology 2014 27:5: 651-656.
  • Ustun C, Wiseman AC, Defor TE, Yohe S, Linden MA, Oran B, Burke M, Warlick E, Miller JS, Weisdorf D. Achieving stringent CR is essential before reduced-intensity conditioning allogeneic hematopoietic cell transplantation in AML. Bone Marrow Transplant. 2013 Nov;48(11):1415-1420.
  • Yohe, Sophia L.; Olson, John D. Thrombophilia: Assays and Interpretation. Laboratory Hematology Practice. 2012 Aug:492-508.
  • Bachanova, Veronika; Burke, Michael J.; Yohe, Sophia L.; Cao, Qing; Sandhu, Karamjeet; Singleton, Timothy P.; Brunstein, Claudio G.; Wagner, John E.; Verneris, Michael R.; Weisdorf, Daniel J. Unrelated Cord Blood Transplantation in Adult and Pediatric Acute Lymphoblastic Leukemia: Effect of Minimal Residual Disease on Relapse and Survival. Biology of Blood and Marrow Transplantation. 2012 June 6(8):18


Board Certifications

Anatomic Pathology, Clinical Pathology, Hematopathology, Molecular Genetic Pathology