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Mark LeSage is a Senior Investigator in the Department of Medicine at the Hennepin Healthcare Research Institute, and Professor in the Department of Medicine and Adjunct Associate Professor in Psychology at the University of Minnesota. His research is primarily focused on the behavioral pharmacology of nicotine and tobacco, with a focus on using nonhuman drug self-administration and other models to address issues related to tobacco harm reduction and FDA regulation of tobacco products. He also employs nonhuman models to study the behavioral pharmacology of other drugs of abuse (cocaine, opioids) and develop immunotherapies (e.g. vaccines, antibodies) and other types of pharmacotherapies to treat drug abuse.