Esther Krook-Magnuson, PhD

Assistant Professor, Department of Neuroscience

Esther Krook-Magnuson

Contact Info

ekrookma@umn.edu

Office Phone 612-301-7747

Lab Phone 612-642-4494

Lab Address:
4-160, 4-164 JacH

Assistant Professor, Department of Neuroscience


Summary

Esther Krook-Magnuson is an Assistant Professor in the Department of Neuroscience. Her work focuses on brain circuitry, including the different types of neurons in the brain and their responsiveness to drugs like opioids.

Research

Research Summary/Interests

Selective Neuromodulation

Neuronal networks, diversity, and specificity of function are important to both physiological processes and neurological disorders, including epilepsy. My laboratory seeks to improve our understanding of how cells interact within a network, how networks interact with each other, and the physiological roles of neuronal populations. In this regard, key questions remain in epilepsy research, including what are the principal networks, conditions, and cell types involved in initiating, sustaining, propagating, terminating, and potentially suppressing, seizures. By improving our understanding of these, we improve the prospects of someday reaching the goal of no seizures, no side effects, for all epilepsy patients. My lab uses rodent models of neurological disorders, including temporal lobe epilepsy, and techniques including electrophysiology, optogenetics, immunocytochemistry, transgenic animals, and behavioral experiments to address these fundamental questions

Publications

Wick, ZC & Krook-Magnuson, E 2019, 'Seizing Sequencing Data to Consider Cell and Circuit Complexity' Epilepsy Currents, vol. 19, no. 2, pp. 124-125. https://doi.org/10.1177/1535759719835658

Zeidler, Z, Brandt-Fontaine, M, Leintz, C, Krook-Magnuson, C, Netoff, TI & Krook-Magnuson, E 2018, 'Targeting the mouse ventral hippocampus in the intrahippocampal kainic acid model of temporal lobe epilepsy' eNeuro, vol. 5, no. 4, e0158-18.2018. https://doi.org/10.1523/ENEURO.0158-18.2018

Christenson Wick, Z & Krook-Magnuson, E 2018, 'Specificity, versatility, and continual development: The power of optogenetics for epilepsy research' Frontiers in Cellular Neuroscience, vol. 12, 151. https://doi.org/10.3389/fncel.2018.00151

Richner, TJ & Krook-Magnuson, E 2018, 'Progress toward precise genetic repair in neurons' Epilepsy Currents, vol. 18, no. 2, pp. 121-122. https://doi.org/10.5698/1535-7597.18.2.121

Zeidler, Z & Krook-Magnuson, E 2018, 'Back to the dentate: Network changes of early- and late- born dentate granule cells' Epilepsy Currents, vol. 18, no. 1, pp. 49-50. https://doi.org/10.5698/1535-7597.18.1.49

Krook-Magnuson, E 2017, 'Illuminating seizures: optogenetic approaches to studying networks in epilepsy' Journal of Neuroscience Research, vol. 95, no. 12, pp. 2323-2324. https://doi.org/10.1002/jnr.24147

Yu, W & Krook-Magnuson, E 2017, 'Targeting newly generated granule cells: A double-edged sword' Epilepsy Currents, vol. 17, no. 2, pp. 121-123. https://doi.org/10.5698/1535-7511.17.2.121

Christenson Wick, Z, Leintz, CH, Xamonthiene, C, Huang, BH & Krook-Magnuson, E 2017, 'Axonal sprouting in commissurally projecting parvalbumin-expressing interneurons' Journal of Neuroscience Research, vol. 95, no. 12, pp. 2336-2344. https://doi.org/10.1002/jnr.24011

Krook-Magnuson, E 2017, 'The gate and the source? The dentate gyrus takes central stage in temporal lobe epilepsy' Epilepsy Currents, vol. 17, no. 1, pp. 48-49. https://doi.org/10.5698/1535-7511-17.1.48

Krook-Magnuson, E 2016, 'Downsides and downstream effects of interictal epileptiform discharges' Epilepsy Currents, vol. 16, no. 5, pp. 325-326. https://doi.org/10.5698/1535-7511-16.5.325